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This study describes the single center experience and long-term results of ABO incompatible kidney transplantation (ABO i KT).400 patients who received an ABO i KT in the period from February 2009 to December 2016 in Asan Medical Center were retrospectively reviewed. After we experienced lethal infectious complications in the first 89 patients (Era1), a pre-transplantation protocol was modified using lower dose of rituximab, selective use of calcineurin inhibitors and anti-metabolite reduction, and prophylactic strategy(Era2).The overall patient survival rates after ABO i KT at 1, 3,and 5 years were 97.9%, 97.4%, and 95.9%.The death censored graft survival rates at 1, 3,and 5 years were 98.9%, 98.1%, and 97.7%. The rejection free graft survival rates at 1, 3,and 5 years were 91.4%, 85.0%, and 82.6%. The overall patient survival rates stratified by era showed a significant difference between era1 and era2 during 5-year follow-up(88.7% vs. 96.7%, P = 0.014) due to infectious complications. Neither was there a significant difference in the 5-year death censored graft survival rates (era1 vs. era2; 98.9% vs. 97.8%, P = 0.85) and the 5-year rejection free graft survival (era1 vs. era2; 85.6% vs. 82.2%, P = 0.34). Infectious complications decreased significantly in era2, including cytomegaloviremia (64.1% vs 30.1%, P < 0.001) and BK viremia ≥ 4logs (15.6% vs 11.3%, P=0.08).ABO-incompatible kidney transplantation can be performed safely with a successful graft outcome. Modification of immunosuppression according to host conditions is recommended for the prevention of infectious complications.