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kidney transplatation.Investigate the quality of life(QOL) in related-living kidney donors after transplantations, achieve a better QOL with health education and clinical intervention based on this study.This study is a cross-sectional, descriptive design. Under the permission of the hospital ethics committee, 30 related-living kidney donors chosed as objects and the general Chinese population as the control. Each subject is given a structural questionnaire that gathers general information as sex, age, job, etc; (2) Medical Outcomes Study Short Form-36 (MOSSF-36) to assess the QOL of subjects. Moreover, the living kidney donors were monitored with Scr, blood pressure(BP) and urine protein during the time of 7 days, 6 months, 1 year, 2 years and 3 years respectively after the surgery. Data was analyzed by Statistical Package for the Social Sciences(SPSS 17.0). Statistical methods such as t-test were used to illustrate data.(1)During the time of 7 days, 6 months, 1 year, 2 years and 3 years respectively after surgery, the serum creatinine of donors increased statistically significantly compared to preoperative serum creatinine (P < 0.01), but the mid-term serum creatinine was only slightly higher than the normal ones. No patients had renal insufficiency. Three years after surgery, the donors experienced a statistically significant decrease of serum creatinine compared to 7 days after surgery (P = 0.027, < 0.05). The mid-term urine protein of related-living kidney donors was negative. The mid-long-term blood pressure of related-living kidney donors showed no difference compared to that before surgery(P> 0.05). (2) 6 months after surgery, comparing to the control,the related-living kidney donors showed no difference in most QOL domains except BP and Mental Health (MH. BP is lower than the reference population and MH score higher than the control. However, 3 years after surgery, the donors showed no difference in most QOL domains except MH comparing to the control. The MH still scored higher than the normal.(3)At 3 years after surgery, males showed no difference in most QOL domains compared with females in most domains except Physical Functioning (PF). The youngers had better QOL scores in all domain compared to the donors exceed 50 years old.(1)After transplantation, the serum creatinine of donors increased in comparison with preoperative serum creatinine, but the mid- term creatinine higher slightly than the normal ones; The mid-term urine protein of donors was negative. The mid-term BP of donors showed no difference between before and after the surgery(P> 0.05);(2) There are no difference in the mid-term quality of life of donors compared to the control except MH;(3) The MH of donors scored higher than that of the general Chinese population.