Epidemiologic Study and Genotyping in Renal Transplant Recipients BK Virus


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Abstract

IntroductionBK virus (BKV) infection occurs during childhood and remains latent in the urinary tract. The virus is reactivated in immunosuppressed patients, particularly in those with cellular immunity deficiency, allowing its detection in urine and blood. The nephropathy caused by the virus in renal transplantation receptors may lead to graft failure.The purpose of this study is to know the prevalence of BKV viral variables in renal transplantation recipients and to evaluate their clinical evolution through molecular methods of “in house” development.Materials and methodsUrine and peripheral blood samples from 66 renal transplantation recipients from the province of Buenos Aires, Argentina, were systematically analyzed every three months as well as when there was graft dysfunction. Renal biopsies, which were included in the BKV detection study, were performed to those patients with graft dysfunction reasons.ResultsSamples from 66 patients were analyzed, out of which 25 patients had positive urine samples, representing 37.87% of the total number.Genotyping of 25 BKV was performed and the following distribution was found: 22 (88.0%) belonged to Subtype I, 3 (12.0%) to Subtype II. BKV belonging to subtypes III or IV were not found.As regards Subtype I Subgroups, the following were identified: 1 (4.0%) from Ia, 11 (50.0%) from Ib1 and 10 (45.45%) from Ib2. Presence of Subgroup Ic was not shown.Nine patients (36%) presented with viremia. Seven of them (77.77%) belonged to the subgroup Ib1.ConclusionPresence of viruria and viremia, because of BKV, matches the presence shown in other national and international studies.Even though an important proportion of the inhabitants of the province of Buenos Aires are European descendants, the prevailing genotype is Ib1, the Asian type.Genotyping could be related to the evolution of the disease in the recipient.

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