Epidemiologic Study and Genotyping in Renal Transplant Recipients BK Virus

    loading  Checking for direct PDF access through Ovid

Abstract

Introduction

BK virus (BKV) infection occurs during childhood and remains latent in the urinary tract. The virus is reactivated in immunosuppressed patients, particularly in those with cellular immunity deficiency, allowing its detection in urine and blood. The nephropathy caused by the virus in renal transplantation receptors may lead to graft failure.

Introduction

The purpose of this study is to know the prevalence of BKV viral variables in renal transplantation recipients and to evaluate their clinical evolution through molecular methods of “in house” development.

Materials and methods

Urine and peripheral blood samples from 66 renal transplantation recipients from the province of Buenos Aires, Argentina, were systematically analyzed every three months as well as when there was graft dysfunction. Renal biopsies, which were included in the BKV detection study, were performed to those patients with graft dysfunction reasons.

Results

Samples from 66 patients were analyzed, out of which 25 patients had positive urine samples, representing 37.87% of the total number.

Results

Genotyping of 25 BKV was performed and the following distribution was found: 22 (88.0%) belonged to Subtype I, 3 (12.0%) to Subtype II. BKV belonging to subtypes III or IV were not found.

Results

As regards Subtype I Subgroups, the following were identified: 1 (4.0%) from Ia, 11 (50.0%) from Ib1 and 10 (45.45%) from Ib2. Presence of Subgroup Ic was not shown.

Results

Nine patients (36%) presented with viremia. Seven of them (77.77%) belonged to the subgroup Ib1.

Conclusion

Presence of viruria and viremia, because of BKV, matches the presence shown in other national and international studies.

Conclusion

Even though an important proportion of the inhabitants of the province of Buenos Aires are European descendants, the prevailing genotype is Ib1, the Asian type.

Conclusion

Genotyping could be related to the evolution of the disease in the recipient.

Related Topics

    loading  Loading Related Articles