The study of relationship between serum levels of soluble VEGF receptor-1and soluble Fibrinogen-like protein 2 with delayed graft function after kidney transplantation

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Abstract

Introduction

Delayed graft function (DGF) is a transplant complication which means needing dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship two immunomodulatory factors of soluble VEGF receptor-1 and soluble Fibrinogen-like protein 2 (sFGL-2) with DGF after transplantation.

Materials and Methods

This case control study was done among 2 groups of 58-member of transplanted patients with and without DGF. The control group included the patients who were operated in 2015 and didn’t show DGF symptoms. Then, serum levels of sFlt-1and sFGL-2 in all blood samples were measured by Elisa.

Results

Serum sFlt-1 and sFGL-2 levels were significantly higher in DGF group compared to those in control group (P≤0.001). sFlt-1 and sFGL-2 serum levels significantly affect on DGF (P<0.001) in such a way that they increase the risk of DGF.

Conclusion

This study showed a significant relationship between sFlt-1 as well as sFGL-2 and DGF. Therefore, plasma levels of sFlt-1 and sFGL-2 may be used as diagnostic tools to determine the risk of DGF.

Keywords

Kidney Transplantation; soluble VEGF Receptor-1; soluble Fibrinogen-like protein 2; Delayed Graft Function

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