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Multivisceral transplantation is currently an acceptable therapy; however, organ shortage is a major impairment for this practice. Xenotransplantation is promising for organ shortage; but it causes hyperacute rejection (HR) that destroy the graft in few hours and still demand advances to be properly treated. In this report, we compare the HR in three species combinations of multivisceral xenotransplantation.Multivisceral grafts (esophagus, stomach, small intestine, colon, liver, pancreas, spleen and kidneys) were recovery and implanted heterotopically in dog-to-pig (n = 5); pig-to-dog (n = 5); rabbit-to-pig (n = 15) combinations. Multivisceral allotransplantation [pig-to-pig (n=5), dog-to-dog (n=4) and rabbit-to-rabbit (n=5)] composed the control group. Three hours after reperfusion, we collected samples from the graft for histopathology.HR was visually noted in xenografts around 15 minutes after reperfusion. The autopsy revealed predominance of mild and moderate HR in esophagus and liver in all combination and stomach in pig-to-dog and dog-to-pig combination and severe HR was predominant in stomach, small intestine, colon, pancreas, spleen and kidneys. The occurrence of HR was absent in allografts. IgG fixation was strong in xenografts and absent in allografts.The three different models of this experiment are relevant to study HR and achieved similar evolution. HR was less aggressive in esophagus, stomach and liver, while it was severe in small intestine, colon, pancreas, spleen and kidneys. allografts reveled normal appearance or mild reperfusion injury in all organs.