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Kidney donation is a relatively safe procedure with minimal adverse effects. But some reports have described the development of proteinuria and hypertension after donation. There are number of reports about safety and good quality of life after living donor kidney transplantation overseas but not enough reports have been published in domestic studies.We evaluated the physiologic and psychosocial impacts after kidney donation in this study.Between April 1988 and April 2010, we performed 201 living donor nephrectomies and obtained information on only 88 (43.7%) donors. We measured the estimated glomerular filtration rate (GFR), blood pressure, body mass index, hemoglobin, cholesterol and assessed prevalence of hypertension and proteinuria. And questionnaire consisted of health status and psychosocial outcomes of donors.The average time after donation was 95.05±85.45 months (range, 6-261). The left kidney was used in 76 patients (86%). There was a total complication rate of 8% but serious complication was absent. Proteinuria was found in 9 patients (10%), hypertension in 11 patients (11%). Glomerular filtration rate decreased from 103.65±25.02ml/min to 76.12±19.90ml/min (P<0.001) and hemoglobin decreased from 13.91±1.62g/dl to 13.01±1.72g/dl (P<0.001). Five patients (6%) developed a postdonation GFR between 40 and 60ml/min and two patients developed below 20ml/min.In questionnaire, most donors did not have problems in a routine life and economic activities. Their satisfaction about donation was very high (92%).Living kidney donation resulted in reduced GFR in the donors. Follow-up of living kidney donors is essential to determine risk factors for deterioration of residual kidney function.