Tech 4X40-40: A No-pump Technique for Transplantation Preservation Procedures

    loading  Checking for direct PDF access through Ovid

Abstract

Body

In 1950s-1960s BIGELOW and GIBBON set down the basis of Hypothermia and concluded that at 15 °C the Metabolism is reduced to ∼ 1/7; it is expected to be ∼ 1/20 at 10 °C. These greatly reduced metabolisms result in consequential reductions in O2 demand ( thus making it much easier to oxygenate needy critically ill Patients ) of Refractory Cardiac Arrest RCA Patients and Road Traffic Accident RTA Patients ( total overall mortality of ∼ 3 million yearly ).After expert Medical Evaluation and application of, in certain needy cases, induced circulatory arrest and muscle paralysis or anesthetics, the helpless Patients are immersed in circulating water at 4 °C protectively or else placed in a ventilated refrigerated van at – 20 °C.

Body

This new technique –Tech 4 - buys time of 45 mins, allowing 4th, 5th or 6th year Medical Students to expose the femoral vessels ( out of Hospitals ), to inset a catheter in the femoral artery and to make a slit in the femoral vein.

Body

100 liters of Solution X40 containing the requisite amount of nutrients and O2 at 4 °C ( the Artificial Blood predicted by Legallois in 1812 ) is infused, using specific and practical modalities through a new tested simple apparatus, into the femoral artery catheter. Used Solution X40 containing patients' blood and CO2 exits the femoral vein slit: this is Tech 4X40 - which possibly will buy time of >15 hours for the Patients : website yeunglungs.com These optimum protective survival measures can, with additional infusion of Solution X40, be stretched up to 40 days = Tech 4X40-40 with the Patients in hospitals at 10-7 °C – if more advantageous.

Body

At this stage, with this optimum life preserving conditions, we have 3 possibilities:

Body

Patients' brains have satisfactory functionality - with 2 possibilities:

Body

(1) All other organs have adequate functionality: Patients are put on - then off CPB using the usual Heart-Lung Machines.

Body

(2) One or more organs have inadequate functionality needing transplantation:

Body

These patients are bridged to transplantation, for up to 365 days – Tech 4X40-365 or more if needed.

Body

(3) Patients' brains are irreversibly damaged:

Body

These Patients are potential donors with their organs kept in-situ in optimum preserving conditions at 10-7 °C for up to 365 days with the same technique Tech 4X40-365 or more if necessary.

Body

Judicious use of Tech 4X40-40 will pave the way for the current transplantation procedures to be effected in optimum conditions worldwide to save possibly one million of these RCA and RTA Patients.

Related Topics

    loading  Loading Related Articles