Post-Liver Transplant (LT) Early Allograft Dysfunction (EAD) is Associated with Lack of Post-LT Renal Recovery

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Abstract

Results

22 (32%) patients did not recover renal function and 21 (30%) patients developed post-LT EAD. Factors associated with lack of renal recovery are demonstrated in Table 1.

Results

EAD was more common in the renal non-recovery group (50% versus 21%, P=0.016). Multivariate logistic regression analysis demonstrated that EAD (OR: 7.25; CI: 2.0-25.8, P=0.002) and baseline serum creatinine (OR: 3.37; CI: 1.4-8.1, P=0.007) were independently associated with renal non-recovery. History of renal dysfunction, duration of renal dysfunction and duration of RRT were not related to renal recovery (P>0.2 for all). The 30-day post-LT probability of renal recovery was 48% in the EAD group and 77% in the no EAD group (P=0.02). Patients who had EAD and renal non-recovery had the worst 1-, 3 and 5-year patient survival while those without EAD and recovered renal function had the best outcomes (P<0.001)

Conclusions

1) Post-LT EAD was independently associated with lack of renal recovery in LT recipients on RRT for a short duration prior to LT. 2) EAD in the setting of renal non-recovery resulted in the worst long term survival. 3) Measures to prevent EAD should be undertaken in LT recipients on RRT at time of LT.

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