The relationship between institutional case volume and clinical outcomes after living donor liver transplantation is not clarified.Methods
We conducted a nationwide retrospective cohort study using the database of Korean National Healthcare Insurance Service. Between January 2007 and December 2016, 7073 adult living donor liver transplantations were performed at 50 centers in Korea. Centers were categorized according to the average annual number of liver transplantations: >50, 10 to 50, and <10.Results
In-hospital mortality rates in the high-, medium-, and low-volume centers were 2.8%, 4.1%, and 6.7%, respectively. After adjustment, in-hospital mortality was significantly higher in low-volume centers (adjusted odds ratio, 2.287; 95% CI, 1.471–3.557; P<0.001) and medium-volume centers (adjusted odds ratio, 1.676; 95% CI, 1.089–2.578; P=0.019) compared to high-volume centers. Long-term survival for up to 9 years was better and ICU and hospital length of stay were shorter in high-volume centers.Conclusions
Centers with higher case volume (>50 liver transplantations/year) had better outcomes after living donor liver transplantation, including in-hospital mortality and long-term mortality, compared to centers with lower case volume (≤50 liver transplantations/year).