NATURAL TOLERANCE: A MODEL FOR Ir GENE EFFECTS IN THE CYTOTOXIC T CELL RESPONSE TO H-Y

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Abstract

It is proposed that T cell nonresponsiveness to H-Y is attributable to natural tolerance, maintained in the periphery by an anti-idiotype suppressor mechanism. Induction of such a suppressor mechanism occurs when H-Y plus certain K or D antigens mimic other self-alleles of K or D antigens either alone or in conjunction with minor histocompatibility antigens. The application of the model to other systems, as well as predictions made from it, are discussed.

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