PRETRANSPLANT BLOOD TRANSFUSIONS HAVE AN ADDITIVE POSITIVE EFFECT ON KIDNEY GRAFT PROGNOSIS IN D/DR-MATCHED RHESUS MONKEYS

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Abstract

The effect of blood transfusions on kidney graft survival in D/DR-matched host-donor combinations was investigated in rhesus monkeys treated with azathioprine and prednisolone. If host-donor combinations were mismatched for D/DR and no tranfusions were given (controls), graft survival ranged from 9 to 22 days. D/ DR matching alone led to survival times of 13 to 66 days with 62% of the animals showing a prolonged survival time (>22 days). However, when three pretransplant blood tranfusions were given in D/DR-matched combinations, the range of graft survival was even better: 19 to 73 days with 90% of the recipients surviving for longer than 22 days. The recipients in this group also had a better kidney function in the first weeks after transplantation than that of the nontransfused D/DR-matched group. Therefore, the beneficial effects of D/DR matching and pretransplant transfusions are additive in the rhesus monkey.

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