Efficacy of plasmapheresis for the treatment of pure red blood cell aplasia after allogeneic stem cell transplantation

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Pure red blood cell aplasia (PRCA) is a complication of ABO major-incompatible stem cell transplantation, likely due to the persistence of memory B lymphocytes of recipient origin, which produce hemagglutinins against ABO antigens on donor RBCs. At present no standard of care is established for this complication.


We report a case of PRCA after allogeneic bone marrow transplantation, successfully treated with plasma exchange (PEX) after failing erythropoietin administration.


The patient fully recovered from RBC aplasia.


This case suggests a role for PEX in the treatment of PRCA after allogeneic stem cell transplantation.

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