Quantitation of human herpesvirus–6 (HHV–6) DNA in a cord blood transplant recipient with chromosomal integration of HHV–6

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Abstract

Chromosomal integration of the human herpesvirus–6 (HHV–6) genome (CIHHV–6) is an important consideration if HHV–6 DNA is detected during the course of transplantation. A 4–year–old girl with refractory anemia with excess blasts type–2 was diagnosed with CIHHV–6 before a cord blood transplantation. HHV–6 DNA was serially quantitated by polymerase chain reaction assay in the transplant period. The possibility of HHV–6 reactivation in a transplant recipient with CIHHV–6 was suspected in our case.

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