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Objective: To evaluate the difference between universal screening and risk-based strategies in the prevention of early-onset Group-B streptococcal (EOGBS) disease. Subjects: Cases of EOGBS disease from 2003 to 2009 were identified by a search of the microbiology laboratory’s computerized database. Interventions: Maternal screening for Group-B Streptococci was done for all pregnant women by taking rectovaginal swabs and urine culture at 35–37 weeks of gestation and for all high-risk cases at the time of presentation. Results: From 2003 to 2009, a total of 87 260 live births were recorded, 1948 neonates were very low-birth weight. We reviewed labor and delivery records for 1268 live births randomly sampled from total live births. Forty-five cases of EOGBS disease were identified during the period of study (overall incidence of 0.51 cases per 1000 live births).