A Meta-Analysis Evaluating the Effectiveness of Two Different Upper Limb Hemiparesis Interventions on Improving Health-Related Quality of Life Following Stroke

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The aim of this article is to quantitatively assess the efficacy of different upper limb interventions on healthrelated quality of life (QOL) in stroke patients.


Two botulinum type A injection (BTX-A) studies and 4 constraintinduced movement therapy (CIMT) studies were separately combined in a meta-analysis using a fixed effects model. QOL mean scores were extracted and transformed into weighted mean differences.


Combined, the BTX-A studies showed no significant improvements in overall health-related QOL. Similarly, a meta-analysis of 4 CIMT studies revealed nonsignificant findings for the domains of activities of daily living, communication, and hand function. A separate meta-analysis of 3 CIMT studies showed a significant increase in strength scores (P = .007); however, sensitivity analysis for this domain due to significant heterogeneity led to a new P value of .078, showing a nonsignificant increase in strength. Further results for memory, mobility, mood, participation, and overall recovery were all nonsignificant.


This report did not show these types of upper limb interventions to be effective in improving health-related QOL in the poststroke population.

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