Ultrasonic Instrumentation for Hematology

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In this paper recent progress on our effort to utilize ultrasound for diagnosing blood disorders is reported. Since the processes of erythrocyte aggregation and hemolysis will alter the acoustic scattering property of the blood, which is a function of the volume concentration as well as the dimension of the cells, ultrasonic backscattering characteristics from erythrocytes were used to study the problem of red cell aggregation and osmotic fragility.

Changes in ultrasonic attenuation of the erythrocytes in Sickle Cell disease were used to characterize the tendency of red cells to sickle or deform under hostile physiological environment. Close relationships between ultrasonic absorption, cell morphology, pH, and oxygen tension of the blood have been observed.

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