Lamb wave scattering from a crack originating at a through-hole is of practical importance because of the abundance of fastener holes used in engineering structures. Notches are often used to simulate cracks so that Lamb wave methods can be more conveniently investigated in the laboratory. A linear, three-dimensional finite element model is employed in this paper to study incremental scattering of the fundamental anti-symmetric (A0) Lamb wave mode from notches emanating from through-holes. The term “incremental scattering” refers to the change in scattering caused by introduction of the notch and is motivated by structural health monitoring for which transducers are fixed and signal changes are interpreted to detect damage. Far-field angular scattering patterns are generated for multiple incident angles and frequencies, and such patterns are experimentally validated at one frequency by laser vibrometry measurements. Comparisons are made between a vertical notch alone (no hole) and notches located above and below the through-hole. Additionally, holes of different sizes are considered to investigate the effect of hole diameter on incremental scattering patterns. Results show that the presence, location and size of the through-hole affect both the shape and strength of notch incremental scattering patterns.