Activated Protein C–Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?


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Abstract

Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C–protein C inhibitor (APC–PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC–PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC–PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 μg/L; 10th to 90th percentile, 0.18–1.01) compared with the control group (n = 41; median, 0.19 μg/L; 10th to 90th percentile, 0.11–0.31; P ≤ .001). APC–PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r =-.19; P = .004), and age (r = .19; P = .004). APC–PCI did not correlate with AAA growth rate (r = .11; P = .14).

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