Acute phase protein concentrations in retired racing Greyhounds

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Abstract

Background:

Retired racing Greyhounds are popular as pets. Greyhounds have several differences in physiological values compared with other breeds, including lower serum α- and β-globulin concentrations. We hypothesized that lower acute phase protein (APP) concentrations could contribute to lower α- and β-globulin concentrations in this breed.

Objectives:

The purpose of this study was to compare serum concentrations of several APPs in Greyhounds with those of other dog breeds.

Methods:

We measured the serum concentrations of C-reactive protein (CRP), haptoglobin (Hp), acid-soluble glycoprotein (ASG), ceruloplasmin (CP), and serum amyloid A (SAA) in 15 clinically healthy retired racing Greyhounds and 11 age- and gender-matched healthy nonGreyhound controls using previously validated methods. Results were compared by Student's t-tests.

Results:

The concentration of Hp by both colorimetric and immunoturbidimetric methods was significantly lower in Greyhounds than in nonGreyhound dogs (P=.0009 and .019, respectively). The concentration of ASG was also significantly (P=.007) lower in Greyhounds, but CRP and CP concentrations were not significantly different between groups. SAA concentration was below the detection limit of the method in all dogs.

Conclusions:

The low serum concentrations of Hp and ASG should be taken into consideration when interpreting APP results in Greyhounds. Because both Hp and some ASG migrate in the α-globulin fraction, these results may explain the low α-globulin concentrations in Greyhounds.

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