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Lymphoma is the most common canine malignancy. Around 80% of dogs present with multi–centric disease that is characterised by enlarged peripheral lymph nodes. However, any organ system can be affected, so presenting clinical signs can be extremely varied. Many factors affect long–term prognosis, so early diagnosis and treatment is important. The treatment of choice is chemotherapy and this is usually an outpatient treatment. Some patients require hospitalisation either because of the extent of disease or because of complications from treatment. This article discusses the importance of recognising patients that require extra care and the role of nursing the patient with lymphoma.