Effects of intravenous administration of dexmedetomidine on intraocular pressure and pupil size in clinically normal dogs

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Abstract

Objective|

To evaluate the effects of the intravenous administration of dexmedetomidine on the intraocular pressure (IOP) and pupil size (PS) in normal dogs.

Animals studied|

Forty-two animals with no ocular abnormalities were included in this study.

Procedure|

Following initial readings (T0) of IOP and PS, the dogs received an intravenous injection of dexmedetomidine (5 μg/kg). Both measurements were repeated 10 min (T10) and 20 min (T20) later.

Results|

There were no significant differences in IOP measurements between T0 and T10, although a significant decrease was observed at T20. A significant miosis was found in the first 10 min after sedation. At T20, the PS slightly increased, resulting in no statistical differences with T0 and T10.

Conclusion|

Dexmedetomidine is an excellent option for surgery or diagnostic ocular procedures in dogs when a specific control of IOP is required. However, it must be used in combination with mydriatics in ophthalmic surgical or diagnostic procedures, which require complete dilation of the pupil.

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