Effects of intravenous administration of dexmedetomidine on intraocular pressure and pupil size in clinically normal dogs

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To evaluate the effects of the intravenous administration of dexmedetomidine on the intraocular pressure (IOP) and pupil size (PS) in normal dogs.

Animals studied|

Forty-two animals with no ocular abnormalities were included in this study.


Following initial readings (T0) of IOP and PS, the dogs received an intravenous injection of dexmedetomidine (5 μg/kg). Both measurements were repeated 10 min (T10) and 20 min (T20) later.


There were no significant differences in IOP measurements between T0 and T10, although a significant decrease was observed at T20. A significant miosis was found in the first 10 min after sedation. At T20, the PS slightly increased, resulting in no statistical differences with T0 and T10.


Dexmedetomidine is an excellent option for surgery or diagnostic ocular procedures in dogs when a specific control of IOP is required. However, it must be used in combination with mydriatics in ophthalmic surgical or diagnostic procedures, which require complete dilation of the pupil.

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