Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds

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Abstract

Objectives:

To compare von Frey mechanical quantitative sensory thresholds (mQSTvF) between pelvic limbs in dogs before unilateral total hip replacement (THR) surgery; to correlate ground reaction forces (GRF) with mQSTvF; to assess changes in mQSTvF after THR surgery.

Study Design:

Prospective clinical study.

Animals:

Dogs (n = 44).

Methods:

mQSTvF and GRF measured using a pressure sensitive walkway were evaluated before, and 3, 6, and 12 months after, unilateral THR. Measurements were recorded from the affected (operated) pelvic limb (APL) and the non-operated pelvic limb (NPL). Random effects analysis and forwards stepwise linear regression models were used to evaluate the influence of time since surgery and patient factors on mQSTvF thresholds.

Results:

There were no significant correlations between mQSTvF data and age, bodyweight or the GRF variables. Preoperative mQSTvF measured at the APL and NPL did not differ (P = .909). mQSTvF thresholds increased significantly after 12 months in NPL (P = .047) and APL (P = .001). In addition to time, APL mQSTvF values were significantly affected by sex (higher in males, P = .010) and body condition score (higher in leaner dogs, P = .035) and NPL mQSTvF values by sex (P = .038).

Conclusion:

Successful unilateral THR results in decreased central sensitization after 12 months.

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