To evaluate the effects of subarachnoid propofol administration (SPA) on analgesia, sedation, ataxia, cardiopulmonary, blood gas variables, and its application in ovariectomy in Jennies.Study Design:
Prospective, randomized, clinical trial.Animals:
Adult Jennies (n = 20; 100–120 kg; 5–7 years old).Methods:
In study 1, 5 Jennies had SPA (n = 5; group 1) through Tuohy catheter, and another 5 control Jennies had normal saline subarachnoid administration (n = 5; group 2). In study 2, 10 Jennies had SPA and ovariectomy (n = 10; group 3). In groups 1 and 3 analgesia, sedation and ataxia scores, cardiopulmonary and blood gas variables were recorded at different intervals before and after PSA. In group 2, only cardiopulmonary and blood gas variables were recorded.Results:
SPA produced pronounced analgesia, mild sedation and minimal ataxia. Heart rate (HR), respiratory rate (RR), pulse rate (PR), rectal temperature (RT), arterial blood pH, PaO2, and PaCO2 were not significantly different from base line values after subarachnoid administration of either propofol or normal saline.Conclusion:
SPA was found to be useful, efficient and feasible procedure for ovariectomy through standing flank laparotomy in Jennies.