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Wireless communications systems enable the end users to be mobile. The majority of the wireless communications networks are cellular networks. Several methods are developed to increase the performance of the cellular networks, which depends on the correct determination of the design parameters as well as the architecture of the system and the traffic requirements. In this study, we introduce a Simulated Annealing (SA) based method to determine the design parameters of a multi-tier cellular network, for which the implementation cost is minimized. The cellular system employs guard channels and allows calls to overflow to upper tiers. We conducted experiments with the SA-based technique on different example problems in two-tier cellular networks and obtained promising results.