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Pressure ulcers are prevalent in nursing home residents. They heal slowly and result in pain and impaired quality of life. Strategies to enhance healing of pressure ulcers are critical to the treatment regime in nursing homes. This article explores the possibility that nursing home residents with pressure ulcers may experience low tissue oxygen and impaired hydration. Pilot data are presented suggesting that some proportion of nursing home residents with pressure ulcers experience low subcutaneous oxygen and that fluid administration increases the low tissue oxygen. Further research in this area is warranted.