High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts


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Abstract

The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

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