WELCOME FROM THE IXA PRESIDENT
Committees
GENERAL INFORMATION
AGENDA-AT-A-GLANCE
FLOOR PLAN
PROGRAMME
Xenotransplantation of transgenic pig ensheathing cells promotes remyelination and axonal regeneration in lesioned spinal cords
Safety and preliminary efficacy of porcine islets and Sertoli cells implanted into an autologous collagen generating device in type 1 diabetic humans
In utero hepatocyte xenotransplantation from pig to lamb
Immunohistochemical staining of transgenic tilapia islets expressing a "humanized" insulin gene
Profile of cytokine gene expression and T-cell receptor repertoire in the rat brain transplanted with fetal porcine neurons
Resistance to islet xenograft prolongation in NOD mice is independent of autoimmune syndrome status
Adult porcine islets transduced with human complement regulatory proteins CD55 (DAF) or CD59 are partially protected from lysis in complement active human serum
Development and characterization of anti-Gal B-cell receptor transgenic Gal−/− mice
Use of molecular modeling to define the structural requirements for high affinity xenoantibody interaction with the Gal α-1,3 Gal carbohydrate
GAS 914, a polylysine containing αGal, prevents acute humoral rejection in hDAF pig to primate heterotopic heart xenotransplantation
Depletion of natural antibody in baboons by continuous infusion of Gal type 2 and type 6 oligosaccharides
Primate immunoglobulin gene expression and the rejection of pig heart and kidney xenografts
Anti-Gal antibody gene usage in naïve and post xenograft Gal−/− mice
Immunoglobulin transgenic and knock-in mice expressing anti-αGal reactive antibodies
Cellular and humoral immune reactions in rats with long-term functioning microencapsulated porcine pancreatic islet grafts
CD4-T cell dependent survival of islet xenografts induced by anti-LFA-1 (CD11a) therapy
Islet xenograft prolongation by anti-CD45RB therapy requires the continued presence of peripheral CD4 T cells
Anti-CD45RB therapy prevents islet xenograft rejection by inhibition of indirect pathway and B cell activation
Intraportally transplanted fish islets experience primary non-function (PNF) in streptozotocin (STZ) - diabetic nude rats but function long-term in nude mice
Role of Ultraviolet B pretreatment on xenogeneic bone marrow engraftment and prevention of GVHD
Identification of costimulation pathways involved in a xenoantigen indirect presentation model
Human T cells stimulated with porcine APC express MHC class II and CD86 and become potent stimulators of naïve human T cells
Restriction of the TCR repertoire of proliferating T cells in the direct human anti-pig pathway is independent of the porcine stimulator
Costimulation across the species barrier: a role for CD40 in the direct xenogeneic pathway
Neither NK cells nor host innate immune signaling through the common cytokine receptor gamma chain are required for islet xenograft rejection
An intact splenic architecture is essential for rejection of xeno-heart grafts in T deficient nude mice
Xenoreactive Galα-1,3Gal antibodies induced in human patients bind preferentially to Gal disaccharide
Anti-Gal monoclonal antibodies induce pig microvascular endothelial cell (PMVEC) activation and apoptosis
Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 anti-Gal antibodies
Anti-Gal IgG1 and IgG3 monoclonal antibodies have different abilities to induce xenograft rejection
Immunoaffinity adsorption for extracorporeal removal of xenoreactive IgM
Anti-Galα1-3Gal IgM and IgG antibody levels in sera of humans and old world non-human primates
Isolation and characterization of CMP-NeuAc hydroxylase gene for expression of Hanganutziu-Deicher antigen
Exploratory studies of efficiency of gene transduction in baboons and rhesus monkeys
The xenoantigenacity in two inbred pigs
Analysis of the major swine xenoantigen in the transgenic pigs with N-acetylglucosaminyltransferase III
Dramatic transition of Galα1-3Gal expression
The study of new SLA class I molecules in Hubei White swines
How will xeno-livers best be used?
Neural cell xenografts
Porcine cytomegalovirus in pigs being bred for xenograft organs: prospects for eradication
Species specificity of baboon and porcine-derived cytomegalovirus (CMV) infection in pig-to-primate xenotransplantation: molecular assays
How many functional PERVs exist in pigs?
Evidence of high frequency of allelic polymorphisms in potentially infectious PERV loci from a transgenic pig herd
Detection of donor cells without transmission of porcine C-type endogenous retrovirus (PERV) in host tissues following pig proislet xenotransplantation in fetal lambs and NOD-scid mice
Identification of a line of miniature swine that does not transmit replication competent PERV to human cells in vitro
Baboon to human bone marrow xenotransplantation in a patient with advanced HIV syndrome: case report and 5 year follow up
Anti-VLA-5 mAb inhibits human hematopoietic stem cell function and enhances porcine hematopoiesis in mixed human/porcine bone marrow cultures on human stroma
Human but not porcine cell adhesion to human fibronectin is mediated by CD29
Ex vivo assessment of transgenic pig hearts overexpressing human decay accelerating factor produced by sperm cell mediated gene transfer
Human complement regulatory mechanisms are able to inhibit complement mediated lysis of human erythrocytes by porcine complement
Formation of immune complexes after organ xenotransplantation
Growth and function of human hepatocytes in pigs
Xenogeneic milieu markedly remodels endocrine cell populations after transplantation of fish islets into streptozotocin-diabetic nude mice
Porcine endothelial cell activation by anti-Gal antibodies results in up-regulation of a Fcγ receptor
Porcine endothelial cell tissue factor (TF)-induction by baboon xenoreactive antibodies in vitro: evidence for pathogenic role of non-Gal elicited antibodies
Complement inactivation or depletion of α-Gal XNA does not abrogate the transcription of early growth response factor-1 (Egr-1) in a model of pig-to-human liver xenotransplantation
Low activity of extracellular nucleotide breakdown pathway in pig endothelium and its implication for xenotransplantation
Molecular mechanism underlying the anti-apoptotic effect of Heme oxygenase-1 derived carbon monoxide
αGal-binding lectin induces protection of pig endothelial cells against human complement and oxidative injury independently of NF-κB activation
Implication of TIMP-1 in the protection against endothelial cell apoptosis
Targeting anti-Gal producing B cells
Antibody responses to carbohydrate antigens
Tolerance to α-Gal epitopes
Effective control of anti-Gal response using a non-antigenic α-Gal conjugate as compared to immunoapheresis in a transgenic pig-to-baboon heart transplant model
Role of T cell depletion in rejection responses of pig-to-primate thymokidney xenotransplantation
Protective effects of recombinant human anti-thrombin III in pig-to-primate renal xenotransplantation
Hyperacute rejection of ex-vivo perfused porcine lungs is associated with apoptosis
Gas 914, α-Gal analogue ameliorates porcine kidney xenograft rejection in baboons
Evidence for down-regulation of anti-Gal antibody response by an α-Gal conjugate (NEX-1285) in a pig-to-baboon heart transplant model
Post-transplant lymphoproliferative disorder associated with primate γ-herpesvirus in cynomolgus monkeys used in pig-to-primate renal xenotransplantation and primate-to-primate renal allotransplantation
Towards the generation of a Gal knockout pig: successful use of porcine fetal fibroblasts for nuclear transfer and gene targeting
A second galacytosyltransferase which SYNTHESIzES the major xenoepitope Galα(1,3)Gal
Reduction of α-galactosyl xenoantigen by gene transfer of endo-β-galactosidase C
Functional and phenotypic analysis of porcine hematopoietic cells that lack expression of Galα1,3Gal on their surface
Successful removal of αGal epitopes from vascular endothelial cells in pig kidneys by ex vivo and in vivo administration of endo-β-galactosidase C
Calcium-dependent activation of naïve xenoendothelium by human naïve neutrophils under physiologic flow: absence of Galα1,3-Gal involvement
Divergent molecular and structural resolution between the porcine and human genomes
Change in expression of αGal and functional molecules on vascular endothelial cells of pig organs after in vivo administration of endo-β-galactosidase C (Endo Gal C)
Xenogeneic serum induces the novel immune coagulant fgl2 in porcine aortic endothelial cells
The pig ICAM-2 gene: structure, location and regulation
Nitric oxide-dependent EC accomodation induced by allo- or xenoreactive antibodies is mediated entirely by adenosine
Interleukin-4 and interleukin-13 protect porcine aortic endothelial cells from injury by human complement and from apoptosis
Induced CD59 expression contributes to protection of pig endothelial cells against killing by human complement without reducing C9 binding
Intrinsic regulation of human complement on porcine cells
Specific expression of human tissue factor pathway inhibitor fusion protein on vascular smooth muscle cells of transgenic mice
Peptide-induced inhibition of the classical pathway of complement activation at the level of C1Q
Effect of platelet inhibition on pulmonary xenograft survival
Immunologic and pathologic features of delayed xenograft rejection (DXR) of pig-to-monkey cardiac transplants after a high activity Y-CVF therapy
Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation
Xenozoonoses monitoring in Canada
A Phase II/III clinical trial interim analysis of PERV transmissibility to acute liver failure patients treated with a porcine based bioartificial liver
Porcine endogenous retroviruses (PERVs): studies on transmission in vitro and inoculation of small animals and non-human primates in vivo
Porcine encephalomyocarditis virus is potential risk in xenotransplantation
Human cytomegalovirus can infect porcine endothelial cells: implications for xenotransplantation
Cytomegalovirus (CMV) infection in pig-to-primate xenotransplantation: clinical manifestations
Comparison of α-Gal immunoapheresis and infusion of α-Gal PEG conjugates in non-human primates
Higher levels of anti-Gal IgM before transplantation are associated with a lower xenograft survival in hDAF pig-to-baboon heterotopic heart transplantation
Protection of ex-vivo perfused porcine lungs from hyperacute rejection by preperfusion
Heterotopic heart transplantation from hDAF+ pigs to baboon
Expression of the human complement regulator hDAF in transgenic pig livers prevents hyperacute rejection after orthotopic xenotransplantation in baboons
Extracorporeal liver perfusion system using human decay accelerating factor transgenic porcine liver in non-human primate
T cell activated macrophages are capable of rejecting pancreatic islet xenografts
Autoimmune destruction versus xenograft rejection of islet transplants in non-obese diabetic (NOD) mice
Murine chemokine gene expression in rejecting pig proislet xenografts and murine proislet allografts
Pancreatic icosapeptide is a marker protein to monitor the viability of xenotransplanted fetal porcine pancreatic tissue
A hierarchy in the requirement for host MHC class II molecules in the rejection of pancreatic islet allo- and xenografts
Immunological characteristics of the protective effect of FK506 in islet xenotransplantation
FTY720 in combination with cyclosporin A inhibits islet xenograft rejection: studies in the pig-to-rat model
Avoidance of humoral sensitization after thymic tissue xenotransplantation in a pig-to-baboon model
Specific elimination of anti-Gal B cells in xenograft recipients by α-Gal ricin
Subpopulation of CD19 negative B-cells partially contribute to natural and elicited humoral responses against porcine antigens in the non-human primate system
Novel phenotype of anti-Gal antibody secreting plasma cells in human bone marrow
Differences in affinity of anti-Gal IgG3 mAbs have little effect in vitro but significantly affects in vivo activity
An in vitro method to activate and differentiate primate B cells for characterization of anti-Gal antibody secreting cells
Peripheral blood lymphocytes in chimeric pigs resist lysis by antibody and complement C
Classical pathway complement inhibition and survival of hDAF pig lungs perfused with human blood
The role of porcine von Willebrand Factor-baboon GPIb interactions in disseminated intravascular coagulation associated with pulmonary xenotransplantation
Glomerular thrombotic microangiopathy in renal xenografts from hDAF-transgenic pigs into cynomolgus monkeys
A preliminary analysis of mice expressing human tissue factor pathway inhibitor in microvascular endothelial cells
The involvement of the novel immune coagulant FGL-2 in thrombosis in acute vascular xenograft rejection (AVR)
Effect of various forms of DAF(CD55) and C1 esterase inhibition (C1-INH) on complement mediated xenogeneic cell lysis
A CD46 minigene generated transgenic pig line and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons
Tolerizing anti-Gal IgG production with transient anti-CD40L mAb and intact active bone (IAB) transplantation
Tolerance induction across a highly disparate xenogeneic barrier by bone marrow transplantation
Induction of molecular chimerism by gene therapy prevents antibody mediated heart transplant rejection
Pathogenesis of autoimmunity after xenogeneic thymus transplantation
Chimeric pig donors producing xenogeneic immunoglobulin and heart xenograft survival
Factors influencing engraftment of porcine hematopoietic progenitor cells in non-human primates
Xenogeneic thymokidney transplantation in a pig-to-baboon model: T cell reconstitution and induction of donor-specific T cell unresponsiveness
TGF-β2 up-regulate Fas/FasL expression of mouse to pig xenogeneic cytotoxic lymphocytes
Human erthrocyte glycoproteins inhibit the recognition of xenogeneic human erythrocytes by porcine Kupffer cells in vitro
Prevention of rolling adhesion of human NK cells to porcine endothelium
CO-stimulation blockade of xenoreactive human and monkey lymphocytes
Adult porcine islet transplantation in non-human primates treated with no or conventional immunosuppression or a non-myeloablative regimen and CD154 blockade
CD4+ T cells are sufficient for triggering rejection of neonatal porcine islet xenografts and are dependent on host class II MHC molecules
More than 53 days survival of porcine islets of Langerhans in the monkey
Direct stimulation of human T-cells by highly purified porcine islets in vitro
Significance of Ig light chain for the binding characteristics of anti-α(1,3)Gal antibody in Gal o/o
Analysis of α-Gal-PEG conjugates in non- human primates: pharmacokinetics and the effect on α-Gal antibody induction
Synthetic Gal oligosaccharides (BSA-Gal) prevent kidney graft rejection but cause liver necrosis when combined with cyclophosphamide in a pig-to-baboon model
Heart explant from chimeric pig (sheep cells) protected from hyperacute rejection by human blood
Evaluation of Cellcept, Prograf, Solumedrol and NEX 1285 for the prevention of xenograft rejection in human CD-46 transgenic pig to baboon heterotopic kidney transplant
Generation and functional characterization of transgenic pigs expressing the human complement regulatory protein CD59
Basiliximab and Rituximab increase survival in pig-to-baboon kidney xenotransplantation
Ureteral stenosis in hDAF pig-to-primate renal xenotransplantation: a phenomenon related to immunological events?
Are anti-endothelial antibodies a prerequisite for acute vascular xenograft rejection?
NK cells and monocytes in xenograft rejection: role of porcine carbohydrate antigens
Effects on an α-Gal-PEG conjugate, NEX1285, on survival of CD46 transgenic heterotopic cardiac xenografts in baboons
Use of NEX1285 and anti-CD20 in pig to baboon heterotopic cardiac xenografts
Organ-specific differences in pig kidney and heart transplantation in baboons: absence of DIC after heart transplantation
Cellular implication in acute vascular rejection of HCD55 pig hearts by baboons
Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors
Improvement in delayed rejection of transgenic pig-to-baboon renal xenografts with administration of rabbit anti-thymocyte serum (RATS)
Improved glycemic control after intraportal transplantation of adult porcine islets in diabetic immunosuppressed rhesus monkeys
Fetal pig pancreas xenograft rejection is associated with selective chemokine and chemokine receptor profiles which are suppresed by CTLA4-Fc and anti-CD40L treatment
Inhibition of human NK cell-mediated cytotoxicity towards porcine cells by CD86 blockade and carbohydrate remodeling
Engineering MHC class I-negative pig cells: effects on human cellular immune responses
Immunostimulatory and immunoregulatory function of porcine CD80 (B7-1) with CD28/CTLA-4-mediated human T-cell interaction
Mammalian cells expressing parasitic immunomodulatory mucins as a novel strategy for achieving xenotransplantation tolerance
Comparison of specificity and magnitude of T cell mobilization after xenogeneic or allogeneic direct recognition
Direct killing of xenograft cells by CD8+ T cells of discordant xenograft recipients
Suppression of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene
Role of recombinant hirudin in a pig-to-human lung transplantation model
Disorders of coagulation following pig-to-cynomolgus kidney xenotransplantation with modified and unmodified organs
TMVA, a novel anti-platelet aggregation agent prolonged discordant cardiac xenografts survival
C1 esterase inhibitor (CI-INH) treatment for maintenance of cardiovascular stability during reperfusion of porcine kidneys in monkey recipients
Characteristics of accomodation and acute vascular rejection in cardiac xenotransplantation
Low molecular weight heparin inhibits baboon serum cytotoxicity against pig cells in a cell viability assay
Low molecular weight dextran sulfate prevents complement activation and acts as an "endothelial cell-protectant" in xenotransplantation and ischemia/reperfusion injury models in vitro
The effect of complement depletion with a high activity Y-CVF therapy in pig-to-monkey renal transplantation
In vitro xenotransplantation model for the analysis of novel, pathway-specific complement inhibitors
Effect of repetitive doses of Y-CVF on pig-to-monkey cardiac xenografts survival
Expression of CD55, CD46 and CD59 in human tissues
Prolonged oxygenation and reduced pulmonary vascular resistance of lungs transgenic for h-DAF (CD 55)
Pig to human lung transplantation: induction therapy with soluble C1-esterase-inhibitor (C1-INH)
The new technology treatment diabetes gangrene low extremities
Human antibody deposition and complement activation on porcine hepatocytes in a clinically applied bioartificial liver assist system
Extracorporeal liver perfusion as hepatic assist in acute liver failure - a review of world experience
A unique in vitro model of xenogeneic heart transplantation using a micro-gravity based CO-culture system: heat shock protein-60 expression and apoptosis
Monitoring of intramyocardial electrograms is a reproducible and sensitive technique for non-invasive detection of cardiac xenograft rejection
Effect of immunoadsorptions on acute vascular rejection of HCD55 pig kidneys by baboons
Human DAF pig kidney ex vivo perfusion with human blood and extracorporeal perfusion in baboons
Administration AD-CTLA4Ig vector locally prolongs the survival of transplanted xenoskin on burn wound
The status of chimeric cells in a human to pig spleen transplantation model
Leukocyte and granulocyte count variation can predict hyperacute rejection in orthotopic liver xenotransplantation from pig to baboon
Assessment of renal function following orthotopic liver xenotransplantation from pig to non-human primate
Multiple pathways may contribute to endothelial cell activation in xenograft rejection in the pig to promate model
Acid-base and electrolyte disturbances in an experimental model of orthotopic liver xenotransplantation from pig to baboon after graft reperfusion. Differences between hDAF livers and unmodified livers
Intraoperative electrolyte and acid-base disturbances during experimental liver xenotransplantation from hDAF transgenic pig to baboon
Hemodynamical behaviour in an experimental liver xenotransplantation model from h-DAF transgenic pig to baboon
Testing artificial livers in the pig: report of a new technique of total hepatectomy that obviates extracorporeal circulation
Prolonged maintenance of critical metabolic functions in extracorporeally alloperfused livers: potential for a unique biological liver assist device
Adenovirus-mediated expression of anti-sense pig α (1,3) galactosyltransferase or human secretor type α (1,2) fucosyltransferase reduces level of Gal α (1,3) Gal epitope on NIH3T3 cells
Changes in the protein and lipid profile after liver xenotrasplantation from pig to baboon
Assessment of graft function by echocardiography in cynomolgus monkey recipients of hDAF-transgenic pig cardiac xenografts
Orthotopic xenogeneic lung transplantation on a pig-to-non-human primate model: first Results
Pig liver xenoperfusion using plasma of acute liver cell failure patients: an experimental model of hepatic support
Study of pig liver xenoperfusion according to different volumes of total human blood
Use of NEX1285 and anti-CD20 in pig to baboon heterotopic cardiac xenografts
The dog-to-pig renal xenograft: a suitable model to study discordant pig-to-human xenografting
Successful extracorporeal porcine liver perfusion for 72 h
Prolonged function of extra-corporeal perfused hDAF transgenic pig livers with human blood
Cyclophosphamide induced anemia in cynomolgus monkey recipients of hDAF-transgenic pig cardiac and renal xenografts
The αGal polymer GAS914 depletes anti-αGal antibodies and prevents hyperacute rejection of hDAF-transgenic pig cardiac and renal xenografts in cynomolgus monkeys
Effect of plasma exchange and deoxyspergualin on the survival of guinea pig hearts in macrophage-depleted C6-deficient rats
Treatment with a short course of LF15-0195 and continous cyclosporine a inhibits acute xenograft rejection in a rat-to-mouse cardiac transplantation model
Regulation of MD-1 expression controls skin xenograft rejection
Xeno-thymus transplantation in thymectomized rats
Cyclophosphamide treatment does not have any effect on serum anti-αGal or anti-pig-hemolytic antibodies and causes a noteworthy decrease in hematocrit for at least 1 month
Effect in vitro and in vivo of a rat anti-CD2 monoclonal antibody (LO-CD2b) on pig to baboon xenogeneic cellular (T and natural killer cells) immune response
Role of CD200:CD200r interactions in regulating islet xenograft rejection
Methotrexate as induction agent in life-supporting hDAF pig-to-primate renal xenotransplantation
Long-term survival on non-splenectomized cynomolgus monkeys receiving hDAF porcine renal xenografts and a maintenance immunosuppression with cyclosporine A mycophenolate sodium and steroids
Methotrexate is an ineffective immunosuppressive agent in baboons
Comparison of two B cell targeting drugs mitoxantrone and cyclophosphamide on anti-pig immunization in baboons
Long lasting effect of splenectomy on IgM xenoreactive antibody production in concordant xenograft model
The effect of soluble complement receptor type 1 on survival of hDAF-transgenic pig cardiac and renal grafts in cynomolgus monkeys
Lymphocytes proliferative responses between PBLC from human and inbred pig (Banna Mini-pig inbred-line)
Genetic polymorphism and expression in various tissues of the miniature swine major histocompatibility complex class I genes, SLA-1, -2, -3, -6, -7 and -8
Characterization of glycosphingolipids in glycosyltransferase- and non-transfected porcine aortic endothelial cells
Identification of carbohydrate that bind canine anti-porcine antibodies
Genetic polymorphisms of the miniature swine major histocompatibility complex class II genes, DRB1 and DQB1
Standardization of procedure for efficient gene transfer into pig kidney cells using lipid-mediated transfection
Integration and expression of HLA-DR genes in transgenic pigs
Production and characterization of transgenic pigs simultaneously expressing human decay-accelerating factor (hDAF) and N-acetylglucosaminyltransferase III (GNT-III)
Banna Mini-pig Inbred-line: an inbred pig-line with high individual similarity evaluated with minisatellite DNA fingerprinting
Reduction of the major swine xenoantigen Galα(1,3)Gal by transfection of the glycoptrotein-3-sulfotransferase (GP3ST) gene
Anti-pig hemolytic antibody levels in cynomolgus monkeys from Indonesia, Mauritius, and the Philippines, and in baboons from Kenya
High levels of anti-pig hemolytic antibodies are associated with hyperacute rejection of hDAF-transgenic pig cardiac and renal xenografts in cynomolgus monkeys
Analysis of the xenoantibody response in a hDAF pig-to-baboon kidney transplant model
Environmental antigens play a critical role in xenograft survival in rat-to-mouse cardiac xenogeneic transplants
Interleukin-12 suppresses B cell responses in rat-to-mouse heterotopic heart xenotransplant recipients
Antibody cross-reactivity in ELISA measuring anti-Gal IgM in sera of xenograft recipients
Induced anti-pig antibodies in baboons: absence of antibodies directed to non-Gal carbohydrate determinants
Differential activation of porcine endothelial cells by human xenoreactive antibodies
Comparative study of anti-non-Gal antibody bound to pig endothelial cells digested with α-galactosidase and endo-β-galactosidase C
Expression of galactose-α(1,3)galactose in pig tissue samples
The role of T cell help in the generation of αGal reactive antibodies
Circulating anti-pig antibodies as potential indicator of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantation
Induction of xenograft accommodation by modulation of elicited antibody responses
The role of xenoreactive natural antibody in pig-to-human lung xenotransplantation
Sustained depletion of anti-αGal and anti-pig hemolytic antibodies in vivo with GAS914, a polylysine containing αGal
Splenectomy in xenotransplantation - suppression of anti-hamster antibody responses in cyclosporin A-treated rats by splenectomy
Anti-pig antibody levels in naïve baboons and cynomolgus monkeys
Characterization of baboon anti-porcine IgG antibodies after rat anti-μ monoclonal antibody treatment
Human and non-human primate anti-galactosyl response after injection of rat monoclonal antibody bearing galactosyl epitopes
Immunosuppression does not prevent a humoral response to xenotransplantation. Clues to the instigation of acute vascular rejection
Inhibition of anti-Gal antibody capture and complement lysis of porcine endothelial cells by soluble Gal-bearing molecules
Impact of a novel strategy to reduce anti-αGal antibodies in a pig to primate life sustaining renal transplant model
Early immunohistochemical changes in CD-46 transgenic pig liver perfused with cynomologous monkey blood
α-Gal PEG conjugates inhibit anti-Gal antibody production in the Gal−/− mouse model
An investigation of arsenic trioxide (As2O3) in the suppression of anti-Gal antibody in baboons
Effect of α-Gal polymers on anti-Gal antibody production by primate cells in vitro
The study of the effect of cobra venom and whole body irradiation on discordant heart xenotransplantation rejection
Induction of B cell tolerance again Gal-α(1-3)Gal in cyclophosphamide (CP)-induced tolerance
Specificity differences between xenoimmune IgG1 and IgG2 antibodies, reactive against adult pig islet cells
The ideal human ABO blood Group and red blood cells for porcine-to-human cardiac xenotransplantation
Anti-αGal antibody responses in cynomolgus monkey recipients of hDAF-transgenic pig cardiac and renal xenografts
Natural xenoreactive anti-pig hemolytic antibodies with non-αGal specificity in cynomolgus monkeys from Mauritius
In search for better immunosuppression in xenotransplantation: Wf10
Anti-Gal IgG1 antibodies can cause rejection of Gal-expressing skin and heart grafts
PAF antagonist UR-12670 alleviates the pathology of acute xenograft rejection and late xenograft rejection in a model of liver xenotransplantation
Xenogenic (pig) venous transplants can be used in reconstructive vascular surgery
Survival of rat skin xenografts on mice treated with a donor specific transfusion and anti-CD154 mAb is IL-4 dependent
Hepatocyte grafting as an alternative to liver transplant
Blockade of iNOS prolongs the survival of rat to mouse skin xenograft by suppressing Th1 cytokines
Induction of heme oxygenase-1 with cobalt protoporphyrin fails to prolong hamster-to-rat kidney xenograft survival
Use of chicken anti-αGal antibodies in preventing anti-αGal antibody mediated cardiac graft rejection in αGal KO mice
Reduced humoral rejection in the gal KO mouse model grafted with porcine cartilage generated in vitro with H-transferase transgenic cells
Early onset of rejection by serological factors in concordant hamster to rat heart xenotransplants causes necrosis
Delayed rejection in a small animal model grafted with porcine cells expressing CTLA4-CD59 chimeric molecule to block pCD86
T-cell mediated rejection of vascularized xenografts in the absence of induced anti-donor antibody response
Rat-to-mouse cardiac and skin xenograft survival in different recipient strains
Preparation and characterization of a monoclonal antibody to porcine CD40
Homing and distribution of human mononuclear cells in rabbits
Role of CD4+ and CD8+ T cells in the rejection of concordant pancreas xenografts
Human neutrophils adhere equally well to human and pig endothelium
Isolation and characterization of mouse-to-rat cardiac xenograft-infiltrating cells by ex vivo propagation
Activation of xenogeneic cytotoxic T cells depends on MAPK kinase activation
Xenogeneic skin graft rejection in M-CSF/macrophage-deficient osteoptetrotic mice
Helper T-cell type 1 or type 2 function of xeno-MHC-restricted T-cell clones in a direct xenoantigen recognition
Interaction of CD4+ T cells and macrophages is required for their activation in murine immune response to pig xenogeneic stimulation
Comparison of in vivo lymphocyte proliferation after allogeneic and xenogeneic heart transplantation in mice
Antibody-mediated xenograft rejection is associated with vigorous IL-4 production in vivo
Ex vivo xenogeneic tolerance induction by TGF-β2
In vivo tracking of activated T-cells in transgenic mice treated with non-depleting anti-CD4 and anti-CD154 monoclonal antibodies alone or in combination
Histopathological findings in cardiac xenografts from hDAF-transgenic pigs into cynomolgus monkeys
Late T cell dependent xenograft rejection involves a much higher recruitment of specific T cells than allograft rejection
Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization
Human T-cell reactivity against adult pig islet cells
CD16 cross-linking via anti-Gal antibodies stimulates NK-cell motility and transendothelial migration
Porcine livers perfused with human blood mount a graft vs. 'host' reaction
Steroid-responsive rejection episodes in cynomolgous monkey recipients of hDAF-transgenic pig renal xenografts
Cellular infiltrates in renal xenografts from hDAF-transgenic pigs transplanted into cynomolgus monkeys
Characterization of anti-porcine CD154 monoclonal antibody
A rapid assay to monitor cell-mediated immunity: CD4 in vitro CMI
Prolonged survival of pig xenografts using chimeric donors and modest immune suppression
An experimental study on the in vitro induced immune tolerance of human T cell to porcine antigen-presenting cells
A novel approach to induce antigen-specific hyporesponsiveness to xenoantigens - role of CTLA4Ig transfected dendritic cells in immune tolerance induction in vitro
Adoptive transfusion purified T cells fails to reject long-term survival xenografts in nude mice
Pig cytokines are important in induction of xenogeneic bone marrow chimerism in a discordant pig to α-Gal KO mouse model but not in pig to WT mouse model
Cyclophosphamide plus busulfan-induced tolerance in rat into mouse xenotransplantation
rhCTLA4Ig induces immune tolerance in mixed murine splenocyte coculture
Signal transducing mechanism of CTLA4Ig transfected swine derm inducing human antigen-specific T cells immune tolerance in vitro
Induction of tolerance in murine T cells with direct anti-pig specificity
Engraftment of transduced bone marrow cells expressing αGal in presensitized hosts
Apoptosis of activation induced xenogeneic cytotoxic lymphocytes
Differential effect of functional abrogation of SLA expression on human-swine xeno-reaction by CIITA gene mutant and CIITA anti-sense RNA
Porcine donor leucocyte infusion leads to long-term chimerism in non-immunosuppressed primates
The immune effect of the discordant heart xenotransplantation produced by intrathymic inoculation with xenogeneic antigen in the primate
IL-4 cytokine gene transfer promotes anti-CD45RB induced long-term survival of islet xenografts
A molecular switch for T cell silencing
CD4+ helper T cells play a critical role in xenogeneic rejection (rat to mouse)
αβ-TCR+ T cells play a critical role in xenoresistance to engraftment (rat to mouse): targeting of host αβ-TCR+ T cells allow engraftment with reduced total body irradiation
Apoptotic events during reperfusion of hDAF renal xenografts transplanted into cynomolgus monkeys
Early and late mechanisms of anti-Gal-producing B cell tolerance induced by mixed chimerism
In vivo assessement of endothelial cell activation in response to human xenogeneic antibodies
Ajoene could be useful to prevent the thrombotic microangiopathy that complicates attempts to induce chimerism in pig-to-baboon xenotransplantation
Pig peripheral blood mononuclear cells are a major factor in the development of the thrombotic microangiopathy that complicates procedures designed to induce chimerism in pig-to-baboon xenotransplantation
Endothelial cell activation in hDAF xenografts with prolonged survival and lack of antibody or complement deposits
Redox modulation of porcine target cells: the combination of nitric oxide and thiol deprivation protects endothelial cells from lysis by IL-2-activated human natural killer (NK) cells
Expression of human decay-accelerating factor in porcine endothelial cells inhibits complement-mediated activation
Human immunoglobulins for intravenous use can modulate xenogeneic endothelial cell activation
Overexpression of wild-type and mutant IκBα inhibit the activation of porcine endothelial cells by LPS
TNF-α and natural xenoantibodies up-regulate common signaling mediators in endothelial cells
Accommodation can be induced in hamster-to-rat lung xenografts and in similar to heart xenografts
Human serum-induced E-selectin expression on porcine aortic endothelial cells is totally complement mediated: evidence for a role of complement in delayed xenograft rejection
Activation of human endothelial cells by mobilized porcine leukocytes in vitro: implications for mixed chimerism in xenotransplantation
Expression of anti- and pro-apoptotic genes in porcine endothelial cells stimulated by TNF-α and their molecular cloning
Vaccinia virus complement control protein inhibits both human serum and NK-induced xenoendothelial killing
Effect of human CRPs and Bcl-xl combined transgenes on protection of porcine endothelial cells
Generation and characterization of porcine aortic endothelial cell lines: a tool to study pig endothelial cell/human immune interactions
Accommodation: contributions by donor and recipient
Subcapsular and intra-portal transplantation of adult porcine islets of Langerhans to the rat
Failure of recipient bone marrow cells to engraft in mouse→rat xenogeneic chimeras
Glucocorticoids do not abrogate endothelial activation in response to islets in an in vitro dog-to-pig model of xenoislet transplantation
Combinational therapies for long-term islet xenograft survival
Establishing a designated pathogen free swine colony for xenotransplantation organ production
Transmission of porcine endogenous retrovirus (PERV) in vivo to SCID-beige mice receiving porcine or porcine and human peripheral blood mononuclear cells
Acceptance of future xenotransplantation of porcine insulin producing cells: differences amongst population groups
Attitudes of different population groups towards future xenotransplantation of porcine insulin producing cells
No evidence for infection of target cell lines with porcine endogenous retrovirus (PERV) from islet cells
Analysis of potential perv transmission to human endothelium in a pig-to-cynomolgus monkey kidney model
Rationale for state participation in progress of xenotransplantation programs
Xenotransplantation as a scientific problem in the context of a university hospital
PERVs: diagnostics, adaptation to human cells, but no transmission to small animals, non-human primates and man
Transplant ethics and human dignity
Geoethical considerations relevant to the Introduction of xenotransplantation
Lack of evidence for PERV infection in pig-to-baboon/human xenotransplantation
Absence of anti-PERV antibodies after exposure to pig grafts
Preliminary study on the welfare of cynomolgus monkeys used in xenotransplantation research
Genome mapping and analysis of porcine endogenous retroviruses in miniature swine
The biological compatibility of liver in two inbred pigs
The drug elimination ability of kidney in two inbred pigs
The RYR1 genotype of two inbred pigs
Unexpected changes in lipid metabolism after kidney and heart transplantation in the pig-to-baboon model
Effect of anti-thymocyte globulin on the adhesion of human lymphocytes to porcine endothelium
Metabolism and function of transgenic and normal pig hearts during perfusion with human blood
A "human" diet does not significantly increase the renal stone risk in pigs before and after unilateral nephrectomy
Serum electrolytes and total protein in cynomolgus monkey recipients of hDAF-transgenic pig renal xenografts
Erythropoietin activity between species: a model for hormonal compatibility in xenotransplantation