Xenotransplant News
Xenotransplantation in the cyclosporine era
Porcine red blood cells as a source of blood transfusion in humans
Characteristics of CD59 up-regulation induced in porcine endothelial cells by αGal ligation and its association with protection from complement
The long-term survival of baboon-to-monkey kidney and liver xenografts*
Ex vivo and extracorporeal perfusion with hDAF pig kidneys*
The effect of mitoxantrone on anti-pig immunization in baboons
Release of pig leukocytes during pig kidney perfusion and characterization of pig lymphocyte carbohydrate xenoantigens
Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons
Aggregation of human platelets in plasma by porcine blood cells in vitro is probably mediated by thrombin generation
Clinical extracorporeal hybrid liver support – phase I study with primary porcine liver cells
An investigation of the effect of thalidomide on anti-gal antibody production in baboons
Letters to the Editors
Letters to the Editors
An Initial Report of alpha-Gal Deficient Pig-to-Baboon Renal Xenotransplantation
Porcine Endogenous Retroviruses (PERVs)
Vascularized Thymic Lobe Transplantation
Cardiac Xenotransplantation
Thrombotic Microangiopathy and Necrosis in Pig-to-Baboon Cardiac Xenografts
Pig-to-Baboon Transplantation Using hDAF-Transgenic Donors
The Study of Mitoxantrone as a Potential Immunosuppressor in Transgenic Pig Renal Xenotransplantation in Baboons; Comparison with Cyclophosphamide
Skin Xenograft of N-acetylglucosaminyltransferase III (GnT-III) and DAF Genes Double Transgenic Pig Survived in Cynomolgus Monkey for 28 days with FK506
Role of Porcine von Willebrand Factor in Pulmonary Xenograft Injury
Anticoagulant and Antiplatelet Strategies in Xenotransplantation
Regulated EC Expression of Tethered Hirudin-CD4 Fusion Protein Inhibits Intravascular Thrombus Formation and Delays Hyperacute Rejection in Mouse Cardiac Xenografts
Survival of Vascularised Xenografts is Prolonged Using Donor Organs from Transgenic Mice Expressing Human CD39
Triggering of Thrombosis by Neonatal Pig Islet Cell Clusters
In Vitro and In Vivo Expression of the Human Anticoagulant Molecules Thrombomodulin and TFPI
Regulated Endothelial Cell Expression of Anticoagulant Proteins TFPI or Hirudin Completely Inhibit Acute Humoral Xenograft Rejection in a Mouse-to-rat Cardiac Transplantation Model
Longterm Treatment with High Dose Recombinant Human Antithrombin in Immunosuppressed Primate Recipients of Porcine Xenografts
Specific Destruction of Porcine Pancreas Xenografts by Activated Macrophages with Upregulated Toll-Like Receptor (TLR) Signaling
Balanced Transgenic Expression of Antioxidant Enzymes Improves the Function and Survival of Mouse Islet Grafts
Islet Oxygen Consumption Rate As a Predictor of In Vivo Efficacy Post-Transplantation
Porcine CTLA4-Ig as a Specific Reagent to Prevent Direct Pathway Xenospecific T Cell Sensitization
Transplantation of Fetal Pig Pancreas into Diabetic RAG1-/- Mice Results in Abnormal Glucose Homeostasis
The Role of Graft Expressed Fas-Ligand in Rejection
Adult Porcine, but not Rat, Islets Fail to Cure Diabetic Athymic Mice when Transplanted via the Portal Vein
Costimulation Blockade Delays the T cell Mediated Heart Xenograft Rejection in Accommodated Rats
Preliminary Results of Gal-Knockout Porcine Bone Marrow Xenotransplantation in Nonhuman Primates
Cardiac Pathology in Porcine to Primate Hetertopic Xenografts Functioning for > 60 Days
Utility of Intramyocardial Electrocardiograms and Serum Troponin-T in Monitoring Long-Term Survivors of Pig-to-Primate Cardiac Xenografts
Monitoring of Potentially Xenotic Viruses in Swine-to-Human Xenotransplantation
Non-Anti-αGal/Non-Anti-Pig Hemolytic Antibodies May Cause Acute Humoral Xenograft Rejection in hDAF Pig-to-Baboon Kidney Xenotransplantation
Passenger Pulmonary Macrophages Play a Key Role in the Coagulopathy and Endothelial Activation Associated with Pulmonary Xenograft Dysfunction
Depletion of Porcine Pulmonary Intravascular Macrophages Attenuates Hyperacute Pulmonary Xenograft Dysfunction
Use of Double-J Ureteral Stent to Prevent Ureteral Stenosis in the hDAF Pig-to-Cynomolgus Renal Xenotransplantation Model
Carbon Monoxide (CO) Prevents Apoptotic Events Related to Ischemia/Reperfusion (IR) Injury in an hDAF Pig-to-Primate Xenotransplantation Model
Value of Protein C and Protein S Levels for Predicting the Outcome of Porcine Renal Xengrafts Transplanted into Primates
Influence of Tirofiban on Hyperacute Rejection of hDAF-Pig Hearts Perfused with Human Blood in a Working Heart Model
Porcine fgl2 Activates Human Prothrombin and is Induced in Xenogeneic Endothelium by Acute Vascular Rejection In Vivo and Human TNFalpha In Vitro
Gal-Conjugate Anti-CD154 Monoclonal Antibody, and Anticoagulation Improve Graft Survival in Pig-to-Baboon Heart Transplantation
Progressive Acute Humoral Xenograft Rejection is Characterized by Microangiopathic Glomerulopathy in Pig to Baboon Kidney Xenografts
Distinct Subsets of Dendritic Cells Regulate the Pattern of Acute Xenogeneic Rejection in a Rat-to-mouse Heart Transplantation Model
Prolonged Survival of Baboons after Orthotopic Xenotransplantation of hDAF Transgenic Pig Hearts Using a Moderate Immunosuppression
PERV Transmission Characteristics of Galactosyl-transferase Knockout Pig Cells
Intracellularly Expressed Single Domain Antibody Prevents the Production of Porcine Retroviruses
Packaging of Human Endogenous Retrovirus Sequences by Porcine Endogenous Retrovirus
Successful Prevention and Treatment of Infections in Long-Term Survivors of Porcine-to-Primate Cardiac Xenotransplantation
A Study of the Prevention of PERV Infection by siRNA
Recombinant Human-tropic Porcine Endogenous Retroviruses are not Present in the Germline DNA of Inbred Miniature Swine
The Human-tropic PERV Transmission Phenotype of Miniature Swine is determined by Exogenous Virus
High Frequency of Recombined Sequences in Human Tropic Porcine Endogenous Retroviruses
Transgeneic Pigs Expressing CTLA4-Ig in Neurons and Xenotransplantation for Brain Repair
Efficacy of Porcine Islet Transplants in Diabetic Cynomolgus Monkeys under Chronic Immunosuppression
Prolonged Survival of Porcine Hepatocytes in Cynomolgus Monkeys
Inhibition of Signals 2 and 3 Allows Long-term Graft Survival of Concordant and Discordant Islet Grafts
Retransplantation of Discordant Xenogeneic Islets using Costimulatory Blockade
Rejection of Discordant Islet Xenografts is Predominantly Mediated by Indirect Antigen Presentation and can be Blocked by Host Macrophage Depletion
Anti-Porcine Endogenous Retrovirus (PERV) Immunity and Porcine Cellular Xenograft Rejection
Role of CD40-CD40L Pathway in Concordant and Discordant Islets Xenograft Rejection
Microencapsulated Adult Porcine Islets Render Streptozotocin-Diabetic Immunoincompetent and Immunocompetent Mouse Strains Normoglycemic
The Expression of hDAF Transgene in the Pig Kidney was Inversely Correlated with the Degree of AHXR in a Pig to Baboon Kidney Transplant Model
Gastrointestinal Vasculitis, a Significant Complication Following hDAF Transgenic Pig to Baboon Kidney Transplantation
G-Protein Coupled Receptors Mediate Monocyte-Induced Endothelial Calcium Signaling and Cytoskeletal Rearrangement
Radiosensitive Marginal Zone (MZ) B Cells and Radioresistant MZ Lymphocytes are Both Essential for Induced, T-independent Xenoantibody Production
NK Cells and Macrophages Play a Pivotal Role in Delayed Xenograft Rejection of Pig-to-Rhesus Monkey Cardiac Transplantations After a High Activity Y-CVF Therapy
Cell-Mediated Rejection in Delayed Xenograft Rejection of Pig-to-Rhesus Monkey Cardiac Transplantations after A High Activity Y-CVF Therapy
Human hDAF Transgenic Pigs Produce hDAF RNA but Fail to Express hDAF Protein on Insulin Secreting β Cells
Specifically Reduced Immunocompetence in Lung Grafts after Xenogeneic Orthotopic Lung Transplantation
Porcine Endogenous Retroviruses (PERVs)
A New Retrospective Study on Transmission of Porcine Endogenous Retroviruses (PERVs) in Patients Treated with a Bioreactor Based on Porcine Liver Cells
Expanded Serology Survey of Biomedical Grade Swine used for Transplantation
The Effect of Cold Ischaemia on Liver Xenoperfusion, a Preclinical Study
Selective and Conditional Depletion of Pig Cells with Transgenic Pigs and Specific Liposomes
Discordant Islet Xenotransplantation Causes Significant Up-Regulation of IL-15 Gene and Protein Expression
Critical Role of Ultrasound Monitoring in the Clinical Management of Primate Recipients of Porcine Kidney Xenografts
Production of Porcine Endogenous Retroviruses in Fetal and Adult Islets in Culture and After Transplantation to Rats
A Study of the Xenoantigenicity of Pig Islet Cells
Evidence that Nile Tilapia Islets do not Express α (1,3) Gal
Rejection of Tilapia Islets in Mice is CD4+ T Cell Dependent
Intracerebral Expression of Cytokines after Syngeneic, Allogeneic, Concordant and Discordant Xenogeneic Neural Tissue Grafting and after Immunosuppression
Formation of Thrombi in Pig to Primate Lung Xenografts
Directly Vascularized Pancreatic Islet Xenotransplantation
Ecto-5'-Nucleotidase Loss From Pig Endothelial Cells on Exposure to Human Plasma
The Cofactor Functions for C4 Fragment Deposition on Xenogeneic Cells
Aberrant Expression of α-Gal on Primary Human Endothelium Does Not Confer Susceptibility to NK Cell Cytotoxicity or Increased NK Cell Adhesion
The Study of New SLA Classical Molecules in Inbreeding Chinese Wuzhishan Pig (Wzsp)
α Gal Digestion by Recombinant Protein and Adenoviral Gene Transfer of Endo-β-Galactosidase C
The Evolutionary Conservation of Immunoglobulin Anti-αGal Genes
The Primate Xenoantibody Responses to Porcine Antigens Demonstrate that the Target Xenoantigens Are Not Organ Specific
Role of HLA-E in the Protection of Porcine Cells from Human NK Cytotoxicity
Lack of αGal Expression on Porcine Endothelial Cells Prevents Complement- Induced Lysis but not Xenogeneic NK Cytotoxicity
An HLA-E Single Chain Trimer Inhibits Human NK Cell Reactivity Towards Porcine Cells
A Study of HLA-G1 Protects Porcine Endothelial Cells Against Human NK Cytotoxicity
The Role of Polymorphonuclear Granulocytes in the Direct Recognition of Xenogeneic Endothelium
An Important Role for NKG2D, an Activation Receptor for Stress Inducible Ligands in Human Immune Response Against Porcine Endothelial Cells
Human Polymorphonuclear Neutrophils are Recruited by Chemokines Derived from Porcine Endothelium
Production of Cloned Pigs from Fibroblasts of the Transgenic Pig Expressing DAF and GnT-III
Beta-cell Replacement for Diabetes Mellitus
The Integration and Expression in Transgenic Pigs for hDAF/hHO-1 Double Genes
Pig Cells that Lack the Gene for α1-3 Galactosyltransferase Express Low Levels of the Gal Antigen
Gene Expression in Rat Islets Using Recombinant Lentiviruses
An Attempt to Produce Cloned Pigs for Xenotransplantation
Frontiers in Biopreservation
Dendritic Cells Co-expressing Recipient and Donor MHC Class II Molecules Can Induce Tolerance of the Indirect Pathway
Dominant Porcine Endogenous Retrovirus-derived Epitopes Defined by Human CD8+ Cytotoxic T Lymphocytes
Maintenance of Xenotransplantation Tolerance by Non-primarily Vascularized Skin or Thymus Xenografts
Soluble Fibrinogen-Like Protein 2/Fibroleukin Exhibits Immunosuppressive Properties
Induction of B Cell Tolerance Against Gal-alpha(1-3)Gal Ag in Cyclophosphamide (CP)∞@plus Busulfan-induced Tolerance
Modulation of Human Anti-pig T Cell Responses by Monoclonal Antibodies Directed to Porcine CD45 Molecules
Serp-1, A Viral Anti-inflammatory Serpin, Attenuates Acute Xenograft Rejection in a Rat-to-mouse Cardiac Transplantation Model
Pig Intercellular Adhesion Molecule-2
FGL-2 Deletion (FGL-2−/−) Leads to Modulation of Mouse Aortic Endothelial Cells(MAECs) in an In Vitro Model of Acute Vascular Xenograft Rejection (AVR)
Porcine Endothelium Activated by Anti-α-Gal Antibody Binding Mediates Increased Human Neutrophil Adhesion Under Flow
Kinetic Profile of Heme Oxygenase-1 (HO-1) Expression in Porcine Aortic Endothelial Cells (PAEC) Exposed to Different Cobalt Porphyrins
IL-4 and IL-13 Gene Transfer into Porcine Endothelial Cells Effectively Induces Cytokine Production and Protection from Human Complement and Apoptosis
IL-4 and IL-13 Induce Cytoprotection in Porcine Endothelial Cells against Complement and Apoptosis through Activation of a PI-3 Kinase/Akt Pathway
Pathogenesis and the Pathology of Delayed Xenograft Rejection of Pig-to-Rhesus Monkey Cardiac Transplantations
Increased Expression of Proinflammatory Cytokines, Th1-Associated Cytokines and IL-10 during Acute Vascular and Cell-Mediated Xenograft Rejections
Spontaneous Baboon Cell-mediated Cytotoxicity to PAECs
Embryonic Intestinal Transplantation in a Human á1,3/4Fucosyltransferase (FUT3) Transgenic Mice Model
Significance of Anti-NeuGc (Hanganutziu-Deicher) Antibodies as non-Gal Antibodies in Xenotransplantation
In Vivo Gene Transfer of Endo-β-Galactosidase C Removes αGal Antigen on Erythrocytes and Endothelial Cells of Heart
Preferential Binding of Anti-Gal IgG to Different Neoconjugates May be Effected by Antigen Presentation or Alternative Antibody Specificity
Deceased Expression of α-gal on Platelets during Inbreeding Progress of Banna Minipig Inbred Line
Overexpression of Human Ecto-5'nucleotidase In Pig Endothelial Cells Increases Adenosine Production And Protects Them From Human NK Cell-Mediated Lysis
Suppressive Subtractive Hybridisation Analysis of TNFa-regulated Gene Expression in Porcine Aortic Endothelial Cells
IL-15 Activated Human Peripheral Blood Dendritic Cell kills Allogeneic and Xenogeneic Endothelial Cells via Apoptosis
Role of Adhesion Molecules in Human Natural Killer Cell-Mediated Killing of Porcine Endothelial Cells and Their Modulation by Oxidation-Reduction
Endothelial Cell Protection and Complement Inhibition in Xenotransplantation
The Novel Molecule Porcine cpn10 Up-Regulated Expression on Endothelial Cells by Human Serum Activation
Successful In Vivo Transfection of Non-Dividing Endothelium by DAPI- Supplemented Liposome-Packaged DNA
Activation of Human Coagulation System by Liver-derived Clotting Factors of Banna Minipig Inbred Line (BMI)
Further Characterization of IgG Antibody Reactivity against Pig Islet Cells in Sera from Xenotransplanted Type 1 Diabetic Patients.
Crossreactivity between Swine Leukocyte Antigen and Human Anti-HLA Specific Antibodies in Sensitized Patients Awaiting Renal Transplantation
GAS 914 Tested on hDAF-Pig Hearts Perfused with Human Blood in a Working Heart Model
Effects of Blocking Human Anti-Pig Antibodies with GAS914 in an ex-vivo Model of Hyperacute Rejection of the Lung
Presence of Cytotoxic Xenoantibodies Directed Against Antigens Found on Pig Nucleated Cells and Absent on Red Cells in Pig-to-Baboon Xenotrasplantation
Does a Previous Xenograft Endanger a Subsequent Allograft? Absence of Humoral and Cellular Alloreactivity in Baboons Sensitized to Pig Antigens
Hyperacute Rejection of Mouse Lung by Human Blood
The Feature of the Membrane Bound Form of Factor I on a Xeno-surface
A Swine Artificial Chromosome as a Novel Expression Vector for the Human DAF Gene
Protection from Hyperacute Rejection of the Liver
Downregulation of Natural Killer Cell-mediated Pig Endothelial Cell Lysis by DAF(CD55)
The Effect of Synthesized Type I Membrane Protein of Fas L on NK Cell-mediated Pig Endothelial Cell Lysis
Early Increased CXC Chemokine Expression in Murine Skin Xenografts
Evaluation of the Rat Liver Microcirculation by Intravital Microscopy during Human Blood Xenoperfusion
Cyclophoaphamide Plus Busulfan-induced Tolerance in Rat into Mouse Xenotransplantation
Hepatic Surgical Anatomy of the Amazon Non-Human Primates and its Pottencial use in Xenotransplantation
Xenograft Survival of Human and Pig Islet Transplants in Nonobese Diabetic (NOD) Mice
Recipient Dendritic Cells Influence Type of Xenogenic Antibody Response
Long Term Survival in a Concordant Model of Xenogeneic Orthotopic Lung Transplantation
Xenograft Rejection is Associated with an Increased Graft Content of Hyaluronan
Endothelial Cell Protection with Dextran Sulfate
C Peptide Determinations in Porcine Neonatal Langerhans Islets
The use of Lazaroid (U74389G) Reduces Reperfusion Injury in Experimental Lung Transplantation. Initial Results
Legal Characterization of Xenografts
Psychosocial Aspects of Xenotransplantation. Survey in Adolescent Recipients of Porcine Islet Cells
Questioning the Inherent Immorality of Producing Transgenic Pigs
Attitudes to Xenotransplantation among Italian University Students
Dignity in Light of Xenotransplantation
Porcine Encephalomyocarditis Virus Model Xenozoonosis
Screening of Porcine Endogenous Retrovirus in Chinese Banna Minipig Inbred Line
Lack of Cross-species Transmission of Porcine Endogenous Retrovirus (PERV) in Pig-to-Baboon Organ Xenotrasplantation with Persistent Depletion of Anti-αGal Antibodies
Susceptibility of Porcine Cytomegalovirus to Antiviral Drugs
A Study of the Prevention of PERV Infection in Pig to Human Xenotransplantation
Analysis of Pol Sequences of Type C Retrovirus Amplified from Two Chinese Pigs' Genome
Lack of Porcine Endogenous Retrovirus (PERV) Transmission to Pig Abattoir Workers
Porcine Cytomegalovirus in Xenotransplantation. Does Immunosuppression Enhance Virus Replication and Antiviral Therapy Reduces Virus Replication?
Interaction of Porcine Endogenous Retroviruses (PERVs) and Porcine Cytomegalovirus (PCMV) with Human Cells in Vitro
Study of C-MYC Oncogene in Hepatocellular Carcinoma
Porcine Pancreatic Islets
Chemokine Expression in Pig to Mouse Neonatal Porcine Islet Xenotransplantation
In vivo Differentiation of Bone Marrow Derived Cells in Insulin-producing Cells
Characterization of Immortal Mesenchymal Stem Cells Derived from Bone Marrow of Banna Minipig Inbred Line
Adult Porcine Islets Produce MCP-1 and Recruit Human Monocytes In Vitro
Microencapsulation of Pancreas Islet Cells
Automated Microscopic Assessment of Islet Equivalence and Purity
Transplantation of H-Transferase Transgenic Pig Olfactory Ensheathing Cells Leads to Remyelination in Non-Human Primate Spinal Cord Lesions
Tilapia Islets are Resistant to the Apoptotic Effects of Human and Murine Cytokines
Autoimmunity is not Responsible for the Rapid Destruction of Encapsulated Islet Xenografts by NOD Mice
Influence of Pluripotent Progenitor Embryonic Cells on the Transplant Against the Host Reaction by Bone Marrow Xenotransplantation in the Experiment. Cells, Embryo, Nobe Marrow, Transplantation, Proteolysis
Induction of Dopamine Neurons from Embryonic Stem Cells for Parkinson's Disease
Induction of Tolerance by Recipient Immature Dendritic Cells in Porcine Islet Cell Xenotransplantation in Mouse
Co-transplantation of Porcine Islets with Sertoli Cells in Type 1 Diabetic Patients Produces Atypical Humoral Immune Responses as Assessed by Elicited Anti-pig Antibodies
Acute Cellular Islet Xenograft Rejection in MyD88 −/− Knockout Mice
The Possible Use of Human Cytomegalovirus UL-18 in the Down-regulation of Human NK Cell-mediated Swine Endothelial Cell Lysis
Study on the Impact of the Indirect Allo-recognition on the Rejection of Epidermal Cells
Initial Results of Xenotransplantation (Tx) in Baboons using Hearts from 1,3-Galactosyltransferase Gene-Knockout (GT-KO) Pigs
hDAF Pig Blood Transfusion in Baboons Induces a Pattern of Non-Anti-Gal Xenoantibodies Similar to that Present at Acute Humoral Rejection of Pig Organs
Detection of HLA Transgenes in Pigs by FISH for Study of Human Xenotransplantation
Troponin-T Levels as a Predictor of Graft Dysfunction in Pig-to-Baboon Heterotopic Heart Transplantation
First Behavioural Study aimed at Investigating Welfare of Primates Paired with Healthy or Xenografted Partners
Donor Preconditioning with Carbon Monoxide (CO) in Pig-to-Primate Xenotransplantation
Transplantation of Fetal Porcine Islet-Like Cell Clusters (ICCs) into Immunosuppressed Cynomolgus Monkeys
Apoptosis in Acute Vascular Rejection of Porcine Organs Transplanted into Primates is not an Antibody Triggered Event
The Development of a Pig Allograft Model as a Surrogate for Hyperacute Rejection in Xenotransplantation
Conditional Immortalization of Fibroblasts for Genetic Engineering of Animals
The Expression of HLA-G1 on Porcine Neonatal Islet Cells By Gene Transfection
Direct vs. Indirect Perfusion in Extracorporeal Liver Xenoperfusion
Stable Production of a Novel Anti-pig Antibody Adsorber
Concordant Vascularised Xenografts are Hyperacutely Rejected by Antibodies Raised after Oral Administration of Xenogeneic Erythrocytes
Effect of Anti-Gal Antibody Depletion and Anti-CD154 Blockade on DXR of Pig-to- baboon Cardiac Transplants
Transgenic Pigs Expressing the Suicide Gene Thymidine Kinase in the Liver
Leflunomide Induces T-independent B Cell Xenotolerance but also Interferes with the Antigenicity of Xenografts Inducing Resistance to Rejection by Non-tolerant B Cells
Rejection of Cardiac Xenografts by CD4+ and CD8+ T Cells
Prevention of Co-Stimulation Molecule Expression using Intracellular CTLA4