CRITICAL ISSUES IN HUMAN ISLET TRANSPLANTATION
New avenues in technologies and tools
New avenues in technologies and tools
Artificial chromosomes, prospects for xenotransplantation
What needs to be targeted?
Pathogens to remove
Is PERV still relevant?
Cross-species transmission and patient monitoring
The Mayo Experience
Current approaches in aminal husbandry for minimizing the risk of transmission of infectious agents
Regulatory update
Islet cells
Human hepatocyte isolation under GMP conditions for clinical transplantation
Revisiting the problem of the limited migration of myoblasts transplanted in a muscle
Towards cell-based therapies for neurological diseases
Potential new therapeutic targets for use in transplantation
Novel biologics
Jak3 inhibitors and PKC inhibitors
Targeting B Cells
Xenotransplantation
Stem cells
Regenerative Medicine
Embryonic stem cells as an unlimited source of tissues and organs
Perspectives on California's support of stem cell research
Xenotransplantation
Comparative approaches to stem cell research and banking
Ethics of organ procurement
Cell transplantation for cardiac repair
Feasibility and safety of Autologous Myoblast Transplantation
Artificial heart
Bridging to allotransplantation with a pig heart -- current considerations
Portal thrombosis
Sirolimus versus mycophenolate mofetil in tacrolimus based primary simultaneous pancreas-kidney (SPK) transplantation
Comparing a corticosteroid and calcineurin-free immunosuppression protocol to a conventional sirolimus, cyclosporine and prednisone-based regimen for pancreas-kidney transplantation
Kidney function after solitary pancreas transplantation
Alemtuzumab is not superior to basiliximab to prevent acute antibody-mediated rejection (AMR) after simultaneous pancreas-kidney transplantation
Successful simultaneous pancreas and kidney transplantation from ABO-incompatible living donors
A comparison of alemtuzumab with basiliximab induction in simultaneous pancreas-kidney transplantation
Experience with alemtuzumab versus rabbit anti-thymocyte globulin induction in pancreas transplantation
Pig kidney expressing both endo-beta-galactosidase C and hDAF prevented hyperacute rejection in baboon without antibody removal
Effects of expression level of Human DAF alone and with Human HO-1 in transgenic pig kidney Ex-vivo perfused with freshly collected human blood
Efficient co-expression of multiple graft-protective transgenes using the 2A system
Biochemical studies of Gal antigens in alpha1,3-galactosyltransferase knock-out porcine small intestine and heart tissue
Transgenic pigs producing the suicide gene thymidine kinase in the liver. Facilitation of human hepatocytes in the pig liver
Pig to primate cardiac xenotransplantation using Gal KO porcine donors
Coagulation cascade activation and formation of Non-Gal antibodies contribute to early xenograft rejection using Gal-TKO pig organs in baboons
Gal-TKO pig lungs are protected from HALR by human blood
Engineering two-dimensional and three-dimensional functional hepatic tissues in vivo using cell sheet engineering technologies
IBMIR elicited by hepatocytes in contact with blood in a model of hepatocyte transplantation
Characterization of humanized livers of mice transplanted with prospectively isolated human liver cells
N-acetylcysteine markedly improves the function of human hepatocytes isolated from severely steatotic donor liver tissue - Potential to increase the liver donor pool
Proliferation and maturation of human fetal hepatocytes in mouse liver following transplantation
Transplantation of immortalized human hepatocytes as treatment for acute liver failure
Cryopreservation of rat hepatocyte encapsulated with the extra-cellular matrix components (Matrigel)
New technique of immotalization using human artificial chromosome for rat hepatocyte
Maturation of human amnion-derived stem/progenitor cells in mouse liver following transplantation
Potential regulatory effect of Nicotinamide or LMW-DS on early islet failure following intraportal transplantation
Beneficial effects of exendin-4 treatment on syngeneic mouse islet transplantation
Increased islet yield by p38 mitogen-activated protein kinase (MAPK) inhibitor infusion of the canine pancreas prior to overnight cold preservation
Genetic and morphological differences in cells from large and small islets
Reducing islet transplant primary graft non-function through implementation of an extended quality control assessment program
Digital image analysis of islet samples yields consistent, reproducible results
Gene expression profiling of human pancreatic islets undergoing simulated process of instant blood-mediated inflammatory reaction
Imaging the peritransplant phase of Clinical Islet Transplantation with Positron Emission Tomography (PET)
Noninvasive detection of human CD4+ T cell-mediated immune response in porcine islet xenograft recipient mice using a nano-Fe3O4 bioprobe for MRI
Myoblast transplantation in Duchenne Muscular Dystrophy
Myoblast transplantation in facioscapulohumeral muscular dystrophy
Myoblast transplantation in Oculo-Pharyngeal Muscular Dystrophy.
Islet autotransplantation - long term results and lessons learned that could be applied to islet allotransplantation
Chronic islet graft loss may be due to inadequate regeneration of transplanted islets
Chronic islet graft loss is due to rejection and/or autoimmune recurrence
Chronic islet graft loss -- Interventional strategies
Crossmatch positive renal transplantation
Recent findings in ABO-incompatible kidney transplantation-classification and therapeutic strategy for acute antibody-mediated rejection due to ABO-blood-group-related antigens during critical period preceding establishment of accommodation
Pathogenesis of antibody-mediated rejection
Introduction and overview of Symposium goals and process
The global transaction of human organs
Economic theory and practice
Iranian model of kidney donation
Ethical consideration of transplantation policy
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112.7
Prevascularization
Designer self-assembling peptide scaffolds
Hyperglycemia and Transplanted Islets
Successful allotransplantation in canines model without immunosuppression
Organ switching - can we make beta cells from the liver?
Islet regeneration from embryonic stem cells
Beta cell regeneration
Hepatocyte regeneration
Complement, DAF and alloreactive T cell immunity
Coagulation dysregulation
NK cell education, activation and inhibition
Toll like receptors in alloimmunity
Instant blood-mediated inflammatory reaction (IBMIR)
Xenogeneic disparities in regulation of coagulation
Genetically modified pigs
Interface of coagulation and innate immunity
Immunity to Pancreatic Islet Allografts
Cellular xenografts
Harnessing regulatory T cells
New immunosuppressive drugs
ITA VS. IAK Better clinical results without better function of islet
Results of 105 solitary islet transplantations in 63 Type 1 diabetic patients in the Swiss-French GRAGIL consortium
Analysis of long-term islet allograft function in recipients with type 1 diabetes given depleting t-cell antibodies for induction immunosuppression
Long-term (10--16 years) insulin-independence in patients given an islet auto-transplant (IAT) after total pancreatectomy (TP) to treat painful chronic pancreatitis (CP)
Update from the Collaborative Islet Transplant Registry
Improved graft survival following islet transplantation using higher sirolimus levels
Graft (TX) of microencapsulated human islets (HI), intercontinentally shipped, into nonimmunosuppressed patients with type 1 diabetes (T1DM
Minimum islet mass required to achieve and maintain insulin independence after total pancreatectomy and islet autotransplantation
Isl et al lografts from non-heart beating donors in Type 1 diabetic patients at Kyoto, Japan
Production of pigs transgenic for siRNAs against PERV
Production of transgenic pigs expressing PERV-specific shRNA with knockdown of porcine endogenous retroviruses (PERVs)
Selection of a designated pathogen-free herd intended for xenotransplantation
International human xenotransplantation inventory
Prevalence of porcine endogenous retroviruses in domestic, miniature and genetically-modified pigs in Japan
Pre-screening of miniature swine may help reduce the potential of transmitting human tropic replication competent porcine endogenous retrovirus
Inflammatory cell recruitment into mouse heart xenografts is dependent on mouse monocyte chemoattractant protein-1 generation and activation of mouse protease activated receptor-1
Xenogenic activation and NFkB-dependent gene expression during mouse hyperacute lung injury are independent of lung TLR4
Genetic induction of human CD47 on porcine cells prevents macrophage-mediated xenograft rejection through inhibitory signaling to SIPR®
An experimental study of macrophages on heterogeneous immunotolerance induced by mixed xenogeneic chimera
Innate immune mechanisms predominate in GT-KO pig organ graft failure in baboons
Downregulation of porcine UL-16 binding protein 1 (pULBP1) expression on endothelial cells by TNFa stimulation and CMV infection
Strategies to prevent porcine endothelial cell-induced IFNg secretion by human NK cells
Cell Transplantation using allogeneic trail expressing liver NK cells mounts antitumor activity against hepatocellular carcinomain clinical liver transplantation
Islet grafts into intramuscular space. A preliminary study using a biodegradable scaffold enriched with vascular growth factors
Overexpression of VEGF in vitro using deferoxamine
Composite Endothelial- Mesenchymal Stromal- Islet Cells; A novel angiogenic approach to promote islet revascularization
The in situ Langendorff perfusion system
Demonstration of improved fertility, Mendelian inheritance, and genetic stability through four generations of α 1,3-Galactosyltransferase (GT) knockout pigs
Survival of porcine islets transplanted into prefabricated omental pouches in rhesus macaques (RM)
Survival and function of allogeneic islets implanted in an omental pouch in cynomolgus monkeys (Macaca fascicularis)
Six month control of diabetes by transplantation of encapsulated pig islets in diabetic primates without immunosuppression
Tissue engineered skin and blood vessel substitutes from in vitro constructs to in vivo application
Tissue-engineered kidney
Prospective identification and characterization of multi-lineage stem cells within the walls of adult human blood vessels. Interest and application for the reconstruction of mesodermal tissues
Effect of pancreatic transplantation on secondary complications
Chronic rejection in pancreas transplantation -- biopsy diagnosis and treatment
The uremic diabetic
The uremic diabetic
Accommodation in xenotransplantation
ABO-mismatched heart transplantation
In vivo and in vitro accommodation to anti-Gal antibodies
Tribute to Paul Lacy
The European Experience using polyclonal T-cell antibodies in simultaneous pancreas and kidney transplantation
Polyclonal T-cell antibodies in Type 1 diabetes of recent onset
Polyclonal T-Cell antibodies in human islet transplantation
A new target for Polyclonal T-Cell antibodies in organ transplantation
Tailored immunosuppression for cellular allografts
Tailored immunosuppression for cellular xenografts
An overview of current approaches to immunosuppression after solid organ transplantation
Solid organ xenografts
Enzymes for Human Islet Isolation -- How I Do It.
Enzymes for Human Islet Isolation -- Which Components Do We Need?
Enzymes for Human Islet Isolation -How I Do It
Enzymes for Human Islet Isolation - How I Do It
Myoblast transplantation
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302.3
Mesangioblasts
Cytoprotective donor and graft pre-treatment of islets
FGL2 and ALLO and XENOTRANSPLANTATION
Vessel formation by vessel-derived and progenitor cell-derived endothelial cells
Repair of spinal cord injury by transplantation of adult olfactory ensheathing cells
Neural cells from stem cells from other sources
Neural xenotransplantation
Stem cells in the treatment of neural diseases
How to recognize a suitable pancreas donor
Metabolic effect of sirolimus versus mycophenolate mofetil on pancreatic graft function -- a prospective randomised study
Alternate approach of arterial reconstruction for portal-enteric pancreas transplantation
Surveillance pancreas biopsies in solitary pancreas transplantation
Impact of recipient comorbidity on pancreas transplant outcome
Present status of pancreas transplantation in Japan - Donation predominantly from marginal donors and modified surgical technique
Outcomes of extended donors in pancreatic transplantation with portal-enteric drainage
The impact of the pancreas after kidney transplant on living kidney graft survival
Pancreas after living donor (LD) kidney transplantation improves long term kidney function
Pig tissue factor pathway inhibitor (TFPI) efficiently binds human factor Xa
Significance of human DAF and thrombomodulin gene transfer for coagulation control in pig to human xenotransplantation
Thrombin formation and inhibition in mouse and pig GalTK/O xenogenic lung rejection
Pharmacological intervention in xenoperfused porcine kidneys. Effects of activated Protein C and Antithrombin on coagulopathy and organ function
Generation and Analysis of Transgenic Mice Expressing Human EPCR
Deletion of GAL and expression of CD39 in porcine neonatal islets inhibits the instant blood-mediated inflammatory reaction
Transgenic expression of human CD39 protects kidneys from ischaemia reperfusion injury through the generation of adenosine and inhibition of CD4+T cells
Generation of a Gal knockout pig expressing human CD39
Quantitative and qualitative comparison of the performance of Serva NB1 Collagenase and Neutral Protease with Liberase HI in the isolation of human pancreatic islets
Estimation of donor useability for islet isolation with modified Ricordi method
Twenty-four hour hypothermic machine perfusion preservation of porcine pancreas facilitates processing for islet isolation
Evaluation of islet quality from donation after cardiac death using a novel extended quality control assessment program
Improved human pancreatic islet purification using the refined UIC-UB density gradient
Degraded collagenase deteriorates islet viability and posttransplant function
Commercially available gas-permeable cell culture bags may not prevent anoxia in cultured or shipped islets
Seven-day culture enhances potency and reduces immunogenicity of porcine islets
P38 mitogen activated protein kinase inhibitor (p38IH) improves the quality of cultured human islets
Generation of maturation-resistant non-human primate dendritic cells with immunomodulatory function in vitro
Composite thymo-islet-kidneys induce tolerance and cure surgically induced diabetes
Signal-Regulatory protein- signaling plays a critical role in controlling host dendritic cell activation and tolerance induction by donor-specific transfusion
Xenogeneic thymokidney transplantation using Galt-KO swine produced by conventional breeding
Development of human T and Treg cells in porcine thymus grafts of humanized mice
Rapamycin enriches CD4 + CD25 hi T regulatory cells in ex-vivo expanded CD4 T cells in baboon
Islet-specific effectors but not tregs determine the extent of disease progression in NOD mouse mode
Engraftment of neonatal porcine islets in diabetic non-human primates by blockade of the CD28/CD40 costimulatory pathways
Orthotopic heart transplantations in the pig-to-baboon model
Viral vector to genetically modify the cells (Lentivirus, AAV, or integrative Adenovirus)
Ex vivo gene therapy for Duchenne Muscular Dystrophy
Autoimmune recurrence in experimental models of islet transplantation
Autoimmune recurrence in pancreas transplantation
CD3 antibodies restore self-tolerance in overt autoimmunity
Xenotolerance
Thymic transplantation in large animal models
Self tolerance of natural killer cells
Functional (Islet Transplant) monitoring
Post-transplantation monitoring of islet grafts in animal models by MR imaging.
Immune Monitoring
Viral load monitoring of islet transplant recipients
POTENTIAL IMMUNOGENICITY OF NON-HEMATOPIETIC ALLOGENEIC (STEM) CELL
Hematopoietic stem cells
Regulatory T cells
Mesenchymal Stem Cells (MSCs) in immunotherapy
Antibodies, fusion proteins, and peptides
Bioartificial liver
Hepatocyte transplantation/hepatocyte generation from stem cells
Xenotransplantation and liver disease
Transplantation of microencapsulated hepatocytes as therapy for fulminant liver failure
Embryonic pig pancreatic precursor tissue as a potential source for transplantation Type 1 diabetes
Genetic engineering of pigs for improved transplant outcomes
Novel transgenic pigs
Engineered tilapia islets
Islet transplantation in type 1 diabetes
Ten years insulin independence after islet allogeneic transplantation for type 1 diabetes
HOKT3gamma Ala,Ala induces higher treg frequencies in islet transplant patients correlating with long-term graft survival
Pancreatic islet cell re-transplantation with exenatide after partial graft failure
Effect of GLP-1 on #946;- and #945;-cell function in isolated islet and whole pancreas transplant recipients
Is islet size an important predictor of sustained insulin-independence following islet auto-transplantation(IAT) after total pancreatectomy (TP) for chronic pancreatitis
Outcomes after pancreatectomy and autoislet transplantation in a pediatric population
Long-term islet allograft survival with increased CD4+CD25+FoxP3+ Tregs in Type 1 diabetic recipients
CMV transmission in Type 1 diabetice recipients of islet versus whole pancreas transplants
Characterization of baboon Non-Gal antibody after pig-to-primate cardiac xenotransplantation
Characterization of natural human anti-non-Gal antibodies and their effect on activation of porcine Gal-deficient endothelial cells
Role of antibodies against N-glycolylneuraminic acid (NeuGc) in acute vascular rejection caused by anti-non-Gal antibodies
IL-4 induces lipogenesis in porcine vascular endothelial cells, which is critical for induction of protection against injury by human complement
B lymphocyte subpopulations involved in rapidly-induced, T-Cell independent xenoantibody formation
In Vitro and In Vivo characterization of preformed baboon Non-Gal antibody
A pig-to-mouse transplantation model to identify the in vivo pathogenicity of antibody in vascular rejection and thrombosis
Comparison between endomyocardial biopsy and cross section histology for the diagnosis of cardiac rejection in heterotopic cardiac xenotransplantation
Role of natural antibody-containing immune complexes for tolerization of B-1b cells via induction of mixed chimerism
Both innate and adaptive MHC class I-dependent immunity impair long-term islet xenograft survival
Downregulation of human anti-pig T cell responses by enhancement of negative costimulatory signals
‘Indirect’ acute islet allograft destruction in NOD mice is independent of donor MHC and requires host B lymphocytes
Human cytomegalovirus infection of porcine endothelial cells induces increased adhesion receptor expression and human leukocyte adhesion
Innate and cognate mechanisms mediate injury to H-transferase transgenic mouse skin grafts
Selective in vivo NK cell manipulations may result in chronic xenograft lesions
Effects of carbon monoxide-releasing molecules on porcine aortic endothelial cells and primate pbmc
Blockade of OX40 signals enhance survival of xeno-islet grafts in spontaneously diabetic NOD mice
Pancreatic tissue committed stem cells (CD45- Sca1+ Lin-) from bone marrow are recruited to the site of islet injury via a SDF-1 gradient dependent mechanism
Blood group ABO antigen expression during differentiation of human embryonic stem cells and its relevance to clinical therapy
In vitro expanded human fetal pancreatic cells differentiate into hepatocytes and cholangiocytes upon treatment with dexamethasone and functionally engraft the liver in a model of toxin-induced liver damage
Intra-bone marrow-cotransplantation of donor mesenchymal stem cells in pig-to-NOD/SCID mouse bone marrow transplantation facilitates short-term xenogeneic hematopoietic engraftment
Mesenchymal stem cell (MSC) co-transplantation promotes islet graft revascularization and function
MSCs protect islets from hypoxia/reoxygenation injury
Hepatic differentiation of mouse ES cells in HF/organoid culture
Age-related effect on the hepatocyte differentiation potential of human mesenchymal stem cells
Efficient osteogenic induction of hTERT-immortalized human bone marrow mesenchymal stem cells
Regenerative medicine based on muscle stem cells
Mesenchymal stem cells for skeletal tissue engineering
Mesenchymal stem cells for bone healing
Induction immunosuppression
Maintenance immunosuppression avoiding nephrotoxic agents
Use of calcineurin inhibitors in pancreas transplantation
Combinatorial strategies to overcome human NK cell rejection of porcine xenografts
Cellular mechanisms of xenograft rejection -- role of macrophages
Encapsulation of pig islets by alginate matrix to correct streptozotocin-induced diabetes in primates without immunosuppression
Deceased donor pancreas utilization in the U.S.
Pancreas donation after cardiac death
Allocation of donor pancreases to pancreas and islet recipients & how should candidates be triaged
New approaches to pancreas preservation
Overview of current FDA regulations including allogeneic islets, autologous islets), and combination products (IND)
Regulatory challenges in manufacturing of pancreatic islets
A discussion of the process including the benefits of accreditation, rationale for becoming accredited and lessons learned
Embryonic stem cells, their pretenders, and prospects for cell therapy
A hypothesis for an embryonic origin of pluripotent Oct-4 stem cells in adult bone marrow and other tissues
Plasticity exists
Challenges to the plasticity hypothesis
Directed differentiation of human ES cells to pancreatic endocrine cells via endoderm intermediates
Xenogeneic Islet Transplantation
Clinical islet transplantation
Islet encapsulation
Approach to the crossmatch-positive transplant
Non-Gal antibodies in xenotransplantation
Impact of GalT knockout on antibody and NK cell recognition
Mechanisms of B-cell Tolerance in Transplantation
Hepatocytes, mature hepatic functions
Differentiation and characterization of human embryonic stem cell derived islet clusters
Hepatocytes derived from adult stem cells
Surrogate islet beta cells
Living donor islet transplantation -- Progress Since 2005
Pancreas donation after cardiac death
Islet Xenotransplantation
Xenotransplantation
Update on porcine endogenous retroviruses (PERV)
The road ahead
The effects of mycophenolic acid on oleic acid- and high glucose-induced cellular reactive oxygen species in rat vascular smooth muscle cells
The effects of inosine monophosphate dehydrogenase inhibition on various stimulation-induced cellular reactive oxygen species in mesangial cells
A co-releasing molecule, CORM-3, attenuates ischemia/reperfusion injury in a new model in pig liver
Immunomodulatory properties of cobalt protoporphyrin administered to nonhuman primates
Beneficial effects of IL-1ra on islet of Langerhans mass and function in vivo
Octreotide attenuates ischemia-reperfusion injury of the pancreas in the rat.
The effects of mixed chimera conducted by natural killer cell depletion with minimally myeloablation on allograft rejection
Induction of long-term allograft survival in immune competent mice by immunotherapy with ex vivo-expanded natural FOXp3+CD4+CD25+ regulatory T cells
Differential cytokine profiles by porcine dendritic cells and regulation of human anti-pig xenogeneic responses
The role of donor NK cells on establishing donor chimerism and on protecting islet graft survival in diabetic NOD mice
Induction of B cell tolerance to incompatible ABO Blood group antigens in transplantation
Induction of human T cell tolerance to porcine xenoantigens through thymus xenotransplantation in mice with an established human immune system
Statins induce protection of porcine aortic endothelial cells against killing by human complement and enhance protection induced by IL-4
Molecular cloning and analysis of serine protease function of porcine factor I
Studies on monkey complement
Non-alpha-Gal mediated injury to porcine liver endothelium is reduced in primates with galactosamine-induced liver failure
A model of antibody-mediated rejection with positive cross-match in a pre-clinical setting in the pig
Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation
Human complement-mediated cytotoxicity of endothelial cells from human membrane cofactor protein transgenic wild-type pigs is equivalent to that from 1,3− galactosyltransferase gene-knockout pigs
Evaluation of red blood cells from _1,3-Galactosyltransferase gene-knockout/H-transferase transgenic pigs for blood transfusion in humans
Identification of potential carbohydrate antigenic targets for human and non-human primate antibodies
Naturally occurring anti-pig antibodies may protect from early xenograft rejection and possibly predispose to accommodation in primates
The impacts of human ABO blood groups on human xenoreactive antibody-mediated cytotoxicity and the protective effect of human decay accelerating factors (hDAF) exogene on the swine endothelium
An in vitro model of pig liver transplantation in humans --pig complement is associated with reduced lysis of wild-type and GTKO PBMC
The role of platelet GPIb and GPIIB/IIIA receptors and CD62P/L selectins in pig hyperacute lung rejection (HALR)
Effects of inhibiting nuclear factor-kappa B on acute vascular rejection
Successful removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-beta-galacgtosidase (ABase)
Investigation of eight SLA gene polymorphisms in Korean native pigs
Porcine cells express more than one functional ligand for the human NK cell activating receptor NKG2D
Single chain trimers of HLA-G reveal peptide antigen-dependent conformation of HLA-G and binding to ILT2 and ILT4 receptors
Critical positions for expression of HLA-E
Porcine sertoli cells influence human lymphocyte proliferation and apoptosis in vitro
Long-term survival of HLA-DR pig skin in SCID mice after reconstitution with human PBMC and short-term immunosuppression
Suppression of macrophage activation in response to porcine xenogeneic stimulus by human CD4+CD25+ regulatory T cells
In vitro evidence of stronger cytotoxicity of porcine keratocytes than endothelial cells in xeno-related rejection
Correction of diabetes by encapsulated tilapia (Fish) islets in diabetic NOD mice treated with costimulatory blockade
Effects of hDAF and HLA-G1 on the inhibition of complement, NK-mediated cytolysis in mini-pigs cells
The effect of intrathymic inoculation to cardiac xenograft rejection with mesenchymal stem cells
Xenotransplantation of porcine Sertoli cells to non-immunosuppressed rats
Human T cells respond less to a1,3-galactosyltransferase gene-knockout (GTKO) than to wild-type (WT) pig cells
Human leukocyte antigen-DR matching improved skin graft from transgenic pigs to accommodate in SCID mice reconstructed with human peripheral blood mononuclear cells
Induction of porcine islet xenograft tolerance to cellular xenograft rejection by CD4+CD25+ regulatory T cells from tolerance mice.
Effects of stains on in vitro humoral and cellular immunity in pig-to-human xenotransplantation
An IFN-g ELISPOT Test for detection of preformed and induced memory lymphocytes
Sequence and genomic organization of pULBP1, A porcine gene encoding a major ligand for the human NK Cell activating receptor NKG2D
DNA micro-array-based gene expression profiling in porcine corneal keratocytes and endothelial cells and comparative analysis associated with xeno-related rejection
A new method for incorporation of functional heparin onto the surface of islets of Langerhans
Toll-like receptor mRNA expression in renal allograft biopsy tissue and in renal proximal tubular epithelial cells
Knock-down of porcine alpha-1,3-galactosyltransferase using lentiviral RNAi
Isolation and Preliminary Characterization of Two cDNA Clones Encoding α1,3− Galactosyltransferase of Chinese Banna Minipig Inbred Line(BMI)
Adenoviral-mediated overexpression of either membrane-bound human FasL or human decoy Fas in pig islets can prolong xenograft survival in rat transplant model
Pig cellular FLICE-like Inhibitory Protein (c-FLIP) overexpression in pig xenograft cells induces resistance to human CD8+ CTL-mediated xenocytotoxicity
Clinical safety and histologic findings in phalloplasty using acellular heterogenous collagen matrix
Pregnancies established with human A20 gene transgenic porcine fetal fibroblast derived embryos produced by somatic cell nuclear transfer
Production of pigs transgenic for human hemeoxygenase- I
Vascular density in human islets transplanted intraportally into the liver
The importance of pig dolichy-phosphate mannosyltransferase for preventing porcine endogenous retrovirus transmission to human cells
Studies on glycolipid antigens in small intestine and pancreas from alpha1, 3-galactosyltransferase knock-out miniature swine
Expression of Green fluorescent protein in pig blastocysts obtained by somatic cell nuclear transfer
Lentiviral mediated gene transfer in a heterotopic heart transplantation model - enhancement by magnetofection
Refinement strategies in the anaesthetic management of nonhuman primate xenotransplantation
Native pancreatic -cells adaptation in Streptozotocin-induced diabetic primates
Beta-score as a tool for pre-clinical model in islets xenotransplantation
A preliminary study on gene expression in Rhesus monkey tissues detected with human microarray chips
Application of a humane endpoint in a transplantation project using nonhuman primates
A refined tether system for nonhuman primates used in Xenotransplantation studies
Morphological and immunohistochemical characterization of one case of PTLD observed in a pig-to-primate xenotransplantation programme with cynomolgus monkeys
A refined tether system for nonhuman primates used in xenotransplantation studies.
Metabolic assays may predict return to exogenous insulin
Xenogeneic infection risk and restriction of individual rights
Investigation of methylation and deletion in PERV 5′ LTR region
The market of human organs
Quality of life after islet transplant
Evaluation of engraftment after single islet transplantation from brain death donor by secretory unit of islet transplant objects index (SUITO index).
Reversal of endothelial dysfunction in type 1 diabetic non uremic patients after pancreatic islet transplant alone (ITA)
Color Doppler Ultrasound (CDU) assessment of blood flow velocities changes in central retinal artery (CRA) of kidney-pancreas (KP), kidney-alone (KA) and islet-alone (IA) transplanted type I diabetic patients.
Total pancreatectomy and autologous islet transplantation for chronic pancreatitis
Study Subject Dropout after Pancreatic Islet Cell Transplantation
Automated, wireless blood glucose collection and reporting system in islet cell transplant recipients
Interim Report of The University of Chicago Series with Islet Transplantation via the Edmonton Protocol
The case of resolution of diabetic nephropathy and autonomic neuropathy and cheiroarthropathy after islet transplantation
Improvement in Diabetic Neuropathy following Islet Transplantation
Insulin secretory reserve is impaired in islet recipients despite return to normoglycemia
Successful transplantation of isolated pancreatic islets of langerhans from an ABO incompatible donor
Patients with type 1 diabetes
Actions of the Japanese Society for Pancreas and Islet Transplantation (JSPIT) for recipients of human islets isolated using Liberase HI
Pilot clinical trial with human islets in barium alginate capsules
Comparable graft function for autotransplanted islets and islet allografts using steroid-sparing immunosuppression with mycophenolate mofetil and cyclosporine in the non-human primate
Possible mechanism of pancreatic b-cell dysfunction by oxidative stress in islet graft
Graft function of pancreatic islets overexpressing suppressor of cytokine signaling 3 (SOCS-3) transplanted into diabetic NOD and diabetic Balb/c mice
Inhibiting DPP-IV activity improves human islet graft function
Effect of anti-CD25 antibodies on T regulatory cells in islet allograft recipients
Defining the immune response in islet transplantation using the immune cell function assay CYLEX® IMMUKNOW®
Follow-up of Cytotoxic Lymphocyte Gene Expression in the Peripheral Blood of Human Islet Allograft recipients
Choice of immunosuppression influences Cytomegalovirus DNAemia in Cynomolgus Monkey (Macaca fascicularis) islet allograft recipients
IL-17 neutralization prevents autoimmune diabetes in NOD mice but does not delay allograft rejection in islet transplantation
Reconstructing the pancreas - Restoration of normoglycemia, exocrine function, and islet innervation by islet transplantation to the pancreas
Comparison of epididymal fat pad and submucosal space with liver as islet transplant sites in a murine model
Donor pretreatment with a novel NF-kB inhibitor, DHMEQ can alleviate the graft damage in syngenic marginal islet transplantation
Increased albumin concentration during human pancreatic islet culture reduces caspase 3 activity and improves in vitro function
Composite islet-kidneys from single donors cure diabetes across fully allogenic barrier in nonhuman primates
Inhibition of the angiostatic factor thrombospondin-1 leads to improved vascular engraftment of pancreatic islets of Langerhans
Hepatic Steatosis and Survival of Intrahepatic Islet Transplants
The use of test gradients to determine the bottom layer density for subsequent continuous isopycnic purification of human islets on a COBE 2991 cell processor
Pancreas preservation with JNK inhibitor protects isolated islets against apoptosis and improves islet graft function
The continuous glucose monitoring system® (CGMS) improves glycemic control in two preclinical goettingen minipig (GMP) models of insulin dependent diabetes mellitus.
Human albumin preserves islet mass and function better than whole serum during pre-transplant islet culture
The influence of a current style of culture on the quality of isolated pancreatic islets
Exendin-4 (Ex4) improves the oral glucose tolerance (OGT) in diabetic rats
A novel human islet transport device combining gravitation free conditions with constant perfusion
Isolation of the islets of Iangerhans from the human pancreas with magnetic retraction
Heterogeneity of human pancreata in perspective of the isolation of the islets of langerhans
Explantation of pancreata without Warm Ischemia Time (WIT) produces highly viable adult Pig Islets (PI)
Mercodia insulin pre-transplantation (IPT) ELISA - a fast and accurate way to determine insulin values from islets before transplantation
Perfluorocarbons, new tool for the preservation of pancreatic islets in vitro
Evaluation of human islets specific functional quality cultured on different fas-permeable membranes
Ulinastatin is a Novel Protease Inhibitor and Neutral Protease Activator
Endogenous pancreatic protease activity and methods for impeding their function
Optimization of a prominent oxygen-permeable device for pancreatic islets
Inducible nitric oxide synthase (iNOS) plays an important role in hypoxic injury to pancreatic beta cells
Localisation of collagenase within islets following infusion into human pancreas
Development of an assay for the detailed study of collagenase-digestion within the islet-exocrine interface of the human pancreas
Collagen VI within the islet-exocrine interface of the human pancreas is not resistant to liberase digestion
Deterioration and variability of highly purified collagenase blends used in clinical islet isolation
Optimal thermolysin concentrations for islet isolation from research-grade pancreata
Testing combinations of Protease Inhibitor and Preservation Solution to improve islet quality and yield
β-cell-Specific Cytoprotection by prolactin on human islets
Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation
Evaluation of laparoscopic distal pancreatectomy for living donor islet transplantation
Human islet purification utilizing a semi-closed automated pump system
Exendin-4 reduces inflammation and preserves viability in human and murine islets in vitro.
Effect of human islet rescue gradient purification on islet yield and fractional cell viability
A new class of oxygen carriers improves successful islet isolation from long-term stored rat pancreata
Phase change material maintains temperature control in an islet shipping container
Islet culture at high surface densities on top of silicone rubber membranes compares favorably to standard culture
Factors affecting human islet isolation efficiency
Autoislet transplantation from a remotely located purification center
Effect of encapsulation on oxygen consumption rate by pancreatic islets
Maintenance of mouse and human islet functions and survival by coculture with human bone marrow and cord blood derived mesenchymal stem cells
Effects of cold ischemia time and islet isolation on inflammatory molecule expression in islets of cynomolgus monkeys (Macaca fascicularis)
The effect of alcohol intake on engraftment of transplanted islets
Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha cell response to hypoglycemia
Intra-portal vein but not intra-hepatic artery infusion of microcapsules in large quantity results in abnormal liver hemodynamics and portal venous thrombosis in recipient dogs
Islet endothelial cell signaling augments beta cell insulin content and release by inhibiting insulin degradation.
Extended quality control assessment of human islet isolation with serva NB1 collagenase & neutral protease - University of Wisconsin-Madison experience
Isolation of porcine islets without liberase using glucose induced differential osmotic shock
Successful islet transplantation from one donor to one recipient by targeting IL-6/IL-6 receptor signaling in mice
Costimulatory blockade enhances chimerism and prolongs acceptance of islet allografts in diabetic NOD mice
Peritransplant therapy with thymoglobulin and Genzyme 29155 delays rejection of intrahepatic porcine islets in nonhuman primates
PK1103
Prolongation of murine allogeneic islet grafts survival by a novel immunosuppressant -- triptolide
Role of TRANCE blockade in murine allogeneic islet transplantation
Exenatide reduces immunosuppressive toxicity on human islets in vitro
The effect of mycophenolic acid on primary isolated porcine and rat islet cell death.
Functional study of RhoGDI alpha in rat insulinoma cell line RIN-5F following Immuno-suppressive modulator mycophenolic Acid treatment.
Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody
Effect of histone deacetylase inhibitors on effector and T regulatory cells in Rhesus macaques
Influence of rapamycin on rat macrophages viability and chemotaxis towards allogenic pancreatic islet supernanent
Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves islet engraftment in humans by reducing post transplant inflammation
Combinational effect of Bortezomib in rapamycin mediated suppression of Rhesus Monkey lymphocytes.
Prolonged islet allograft survival by Alpha-1 antitrypsin
Alpha-1 antitrypsin treatment of spontaneously diabetic NOD mice receiving islet allografts
The effect of Cyclosporin A (CsA) and FK506 on the expression of the Na+-Ca2+ exchangers NCX1, NCX2 and NCX3
Labeling of human pancreatic islets of langerhans with Endorem® for noninvasive magnetic resonance imaging following transplantation
Correlation of histopathology, islet yield, and graft function pancreastectomy/islet autotransplantation for chronic pancreatitis
Comprehensive analysis of human pancreatic islets using flow and laser scanning cytometry
Computer-assisted method for counting of non-purified pancreatic islets
Evaluation of cell composition and beta cell apoptosis in isolated undissociated pancreatic islets by laser scanning cytometry
Comparison of cell composition of whole vs. dissociated human islets using laser scanning cytometry
Computer-assisted digital image analysis of human islets
Evaluation of three mouse models for in vico quality assessment of human islets
The impact of non-endocrine cells on islet potency
Development and validation of an HPLC method for the assessment of human pancreatic islet metabolic state
Long-term survival and function of intraportal porcine and human islets xenografts in non-diabetic nude mice
Real-time non-invasive assessment of pancreatic ATP levels during preservation
ATP/DNA may be a better predictor of islet cell viability than the ATP/ADP ratio
Hypoxia induced changes in gene transcription, viability and glucose stimulated insulin secretion in human and rat pancreatic islets
Clinical magnetic resonance imaging of allogeneic islet grafts after iron-labeling
Labeling of pancreatic islets with iron nanoparticles for magnetic resonance imaging
Transmission electron microscopy of islets labeled with iron nanoparticles for magnetic resonance imaging
MRI monitoring of pancreatic islets transplanted into the right liver lobes of diabetic mice - preliminary Results
Monitoring of human islet of Langerhans with MRI using iron nanoparticules labelling
Transplant estimated function (TEF)
Use of Continuous Glucose Monitoring (CGM) to Assess Islet Cell Transplant Candidacy & Success
Islet transplantation program from non-heart beating donors, report from the Japanese Islet Transplantation Registry
Establishment of mouse pancreatic stem cells line
Monocytes derived stem cells differentiated into neoislet
Analysis of Dickkopf-3 expression in normal and tumor adult human pancreatic tissue -different localization, different function?
Effects of streptozotocin (STZ) on in vitro long-term cultured human islet cell monolayers
Preadipocyte factor (Pref)-1 expressing pancreatic cells in vivo & in vitro; as a pancreatic protodifferentiated cells
Improved secretory function of small pancreatic islets generated by reaggregation in Hanging Drop cultures
Mechanisms of islet mesenchyme-to-epithelial transition
Mesenchyme-derived islets do express the pancreatic master gene PDX-1
Combination of CTLA4-Ig and Anti-ICOS monoclonal antibody therapy prevents neonatal orcine islet xenograft rejection
Pancreas-derived mesenchymal stem cells are feeders cells for b cells in islet transplantation
Mesenchymal cells emerging from cultured human pancreatic endocrine and exocrine tissue derived from the CD133+/CD73-Ductal precursor EMT
Participation of bone marrow derived cells in islet regeneration after streptozotocin injection and partial hepatectomy in mice
Differentiation of CD133 positive pancreatic cells into insulin producing isletlike cell clusters
Novel transplantation approach for Type 1 diabetes
Effect of anti-adenoviral immunity on long-term vector and islet graft function
Islet cell proliferation induction using cell cycle modulating TAT fusion proteins
Development of b-cells in the native pancreas after pancreas transplantation in spontaneously Type 2 diabetic torii rat
Neonatal pig liver as a potential new source for insulin producing cells
Effects of Poly-L-Lysine and collagen on FH-B-TPN cell differentiation into endocrine cell phenotype
The replicative capacity of islet β-cells after transplantation
‘Off the shelf’ human Treg cells in xenotransplantation of embryonic pig precursor tissues
Modification of standard isolation procedures increases yield, purity and viability of porcine islet cells (PIC)
Pig islet-human endothelial composite grafts effect on xenoislet instant blood-mediated inflammatory reaction
Creating a prevascularised site for islet transplantation using a V.A.C.®-GranuFoam® and HBO in rats
Combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induces species-specific tolerance to neonatal porcine islet xenografts by regulatory T cells
Induction of tolerance to neonatal porcine islet xenografts using a combination of anti-LFA-1 and anti-CD154 does not require CD4+ or CD8+ T cells
Inhibition of xenograft immune response to porcine islets by adult porcine Sertoli cells
AntiCD3 Combined with Costimulation Blockade Indefinitely Prolonged Graft Survival in Pig to Mouse Islet Xenotransplantation Model
Development of a novel extracorporeal perfusion system to remove preformed anti-pig antibodies in life supporting pig-to-nonhuman primate kidney xenotransplantation
Matrigel and endothelial progenitor cells enhances engraftment in subcutaneous islet transplantation
Targeted local delivery of Immunosuppressive agents for islet survival
Regulation of insulin production in tilapia islet cells
Tilapia islets express two different insulin genes that are transcribed at substantially different levels
Doxycycline-regulated expression of VEGF-A and Angiopoietin-1 transgenes in islet beta cells
Impact of macrophage migration inhibitory factor on islet engraftment
Macrophage migration inhibitory factor (MIF) plays a key role on long term glucose regulation
Importance of donor age in novel small animal model evaluating the contribution of human islet amyloid polypeptide in failure of transplanted islets
Improving pancreatic islet cell function and survival through PKC ± activation
Islets implanted intraportally are exposed to low oxygen levels both before and after revascularization
Exendin-4 improves glycemic control of diabetic mice treated with syngeneic marginal mass islet transplant
Thrombomodulin liposomal formulations enhance allogeneic islet engraftment
Intrahepatic islet transplant in the mouse
Rapamycin impairs β-Cell proliferation in vivo
A combination of islet pre-culture and recipient treatment with exendin-4 is required to improve the outcome of rat islet grafts in diabetic athymic mice
The novel caspase inhibitor EP1013 promotes human islet survival in vitro and enhances marginal islet graft function following islet transplantation
Long term insulin independence with no evidence of islet dysfunction or fibrosis following marginal mass islet unpurified autograft transplantation in swine
Adenosine A2A receptor agonist ATL146e improves islet transplantation outcomes in mice
Riboflavin inhibits p38 activation and IL-6 production in islet cells
Islet-induced coagulation occurs in vitro in autologous, allogeneic and xenogeneic blood
Diabetic retinopathy in a pancreas transplant center
Daily glucose variation measured by continuous glucose monitoring system in normal glucose tolerant patients with pancreas transplantation as compared to healthy controls
Increased 72 hour glucose concentration measured by continuous glucose monitoring system in normal glucose tolerant patients with pancreas transplantation
Extraperitoneal pancreas transplantation with systemic -- enteric drainage
The initial Australian experience with portal-enteric drainage for simultaneous pancreas kidney transplantation
Optimization of the blood supply to the pancreas allograft
Does recipient age influence outcomes in pancreatic transplantation?
3-Year outcomes with early steroid withdrawal after thymoglobulin induction for pancreas transplantation
Simultaneous pancreas-kidney ( SPK ) versus simultaneous cadaver pancreas and living-donor kidney ( SPLK ) transplantation -- A single center analysis of 249 cases
Kidney graft function after pancreas transplantation
Changes in Renal Function after Solitary Pancreas Transplantation with Primary Enteric Drainage
Pancreatic re-transplantation
Clinical evolution comparison between insulin dependent diabetic patients on the waiting list and after pancreas transplantation
No induction protocol in simultaneous pancreas-kidney transplantation (SPK)
Need of reoperation after pancreas transplantation
Solitary pancreas transplantation without HLA matching- analysis of 154 cases
oes a pancreas after living donor kidney transplant (PAK) reduce the risk to die from cardio-vascular disease?
NEORAL® versus PROGRAF® in simultaneous kidney-pancreas transplantation with portal-enteric drainage. 5-Year results of a single center, open, prospective, randomized, parallel groups, pilot study
Pancreas transplantation with a minimum follow-up of 5 years
Risk factors for chronic pancreas rejection
Pancreas after living donor kidney transplantation is associated with improved glycemic control
Quintuple immunosuppression in simultaneous pancreas-kidney transplantation
Pancreas retransplant (retx) after long-term pancreas function (>5 Years)
Organ preservation with histidine-tryptophan ketogluatarate (HTK) solution in clinical pancreas transplantation
Pancreas refused for transplants - clinical and histopathological correlation
Simultaneous bilateral lung and pancreas transplantation in a recipient with Cystic Fibrosis
Does pre-transplant C-peptide level determine outcomes in simultaneous kidney-pancreas transplantation?
Cardiovascular evaluation of type 1 diabetics with nephropathy for simultaneous pancreas-kidney transplantation
Pancreas transplantation prevents cellular oxidative stress in kidneys of alloxan-induced diabetic rats
The role of the 16-multidetector computed tomography (16 MDCT) in visualization pancreatic graft vessel thrombosis in postoperative period
Prevalence of BK-viremia and viruria in simultaneous pancreas/kidney transplant (SPK) recipients
Comparison of high resolution contrast enhanced MR angiography versus digital subtraction angiography in the evaluation of pancreas allografts
Late acute humoral rejection
Temporal relationship between successful pancreas transplantation and control of ocular complications in alloxan-induced diabetic rats
Normal bone metabolism after pancreas transplantation with either systemic or portal venous graft drainage in inbred rats
BK-virus nephropathy in simultaneous pancreas/kidney recipients
Epidermal nerve fibre depletion in simultaneous pancreas and kidney transplant patients
Acute graft pancreatitis
Analysis of bacteremia after pancreas transplantation with enteric drainage
Encapsulated xenogeneic hepatocytes for the treatment of inborn errors of metabolism
Development of an implant type bioartificial liver - Reconstruction of a liver organoid using an apatite-fiber scaffold in the radial-flow bioreactor
Transplantation of the liver organoid reconstructed using an apatite-fiber scaffold column in the radial-flow bioreactor
A mouse bearing a liver populated with human hepatocytes as an animal model to study biological and pathological features of human hepatocytes in vivo
A successful in vivo proliferation of factor IX-producing hepatocytes in mice for cell-based therapy of hemophilia B
A novel technique for liver cold preservation with oxygenation by using a two-layer method in hepatocyte transplantation
Short term cultivation of primary pig hepatocates in a bioartificial liver support system
Hepatic differentiation of mouse ES cells in a bioreactor using polyurethane/spheroid culture
Viability and function of human hepatocytes labelled with superparamagnetic iron oxide nanoparticles for cellular MR imaging
Bilirubin as a cytoprotective agent for cryopreservation of human hepatocytes.
Short tandem repeat analysis on microdissected samples of explant liver tissue after hepatocyte transplantation
Developing a novel standalone rotary cell culture device (RCCS) for bioartificial liver (BAL) support
Cell choice and construction of a bio-artificial liver device to treat liver failure
Induction of a pig model of acute liver failure with minimally invasive laparoscopic surgery to evaluate cell therapy
Introducting small human hepatocytes for the treatment of alcohol addicts
New vitrification solution for microencapsulated islets
Development of an acellular dermal matrix (ADM), which is suitable as a scaffold for clinical application of a tissue-engineered skin equivalent
Protective effect of portal blood arterialization by a new extracorporeal device to treat toxic acute liver failure in the swine model
Development of articular cartilage grafts using organoid-formation techniques
Motor function Recovery of patients with traumatic spinal cord disease in the long-term period after intrathecal transplantation of autologous hematopoietic stem cells
Ischemic central necrosis in pockets of implanted myoblasts in nonhuman primates
A semi-manual multiple-injection device for intramuscular myoblast transplantation
Prevention of ischemia-reperfusion injury of cardiomyocyte by inhibiting transglutaminase 2
Culture under low oxygen conditions markedly enhances differentiation of murine embryonic stem cells into cardiomyocytes
The experimental study on the effect of transplanting time-window of Autologous BM-MSCs to cardiac function to treat ischemic cardiopathy
The experimental study on the effect to cardiac function by intramyocardial transplantation of mobilized autologous bone marrow stem cells after myocardial infarction
Vascular repair in ApoE-Knockout mice with bone marrow cell therapy
Immunogenicity of repeated dosing of an allogeneic cellular therapy
Immunological evaluation of the early post transplant period in pediatric bone marrow allotransplantation
Immunosuppressive effects of embryonic stem cells and mesenchymal stem cells on alloimmune response
Intervention of autoimmunity in NOD mice by co-transplantation of allogeneic bone marrow cells (BMC) and mesenchymal stem cells (MSC)
Efficient for ex vivo expansion and high level purity of human umbilical cord blood (UCB) CD34+ cells under co-culture with murine stromal cell line, NIH3T3
Establishment of immortalized porcine mesenchymal stem cells from Chinese Guizhou minipig by transfection of h-TERT gene
Generation of pigs transgenic for human thrombomodulin by somatic nuclear transfer
Full-length cDNA cloning of porcine Factor VII, and comparative analysis with Human Factor VII.
Characterization of porcine full-length cDNA of Factor X, and comparative study with Human Factor X.
A comparative study of coagulant and anticoagulant function in Rhesus Monkey, human and pig
cDNA cloning, protein structure modeling of Rhesus Monkey(Macaca Mulatta) prothrombin
Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells
Whole blood coagulation assessment using novel rotational thromboelastometry (ROTEM®) in seven naïve cynomolgus monkeys
ROTEM® thromboelastometry in primate recipients of porcine kidneys.
Immunological characterization of the Prothrombinase Complex and Protein C anticoagulant pathway in primates and pigs
High dose recombinant human Activated Protein C (rhAPC) does not prevent the onset of acute humoral rejection of porcine xenografts transplanted into primates
Eliminating oxygen supply limitations for transplanted microencapsulated islets
Studies on polyvinyl alcohol (PVA) macro-encapsulated islets
Cell surface modification using poly(vinyl alcohol) derivative
Enclosure of islets with thin-layer membrane of poly(vinyl alcohol)
Increased frequency of glucagon cells after microencapsulation and transplantation of pancreatic islets
Microencapsulation of pancreatic islets within GLP-1 functionalized Poly(ethylene glycol) (PEG) hydrogel using selective withdrawal
Optimisation of xenografted encapsulated fetal pig islet-like cell clusters
In vitro study of using calcium phosphate cement as immunoisolative device to enclose insulinoma/agaros microspheres as bioartificial pancreas
Preimplantation of the immunoprotective chamber improved the outcome after encapsulated islet transplantation
Quantitative RT-PCR gene profiling of a novel human pancreatic cell line termed h Pan
The immunoprotective properties of primary Sertoli cells compared with a mouse Sertoli cell line
Genetically engineered Sertoli cells as a vehicle for gene therapy
Biodritin® microencapsulated human islets