Current status of xenotransplantation and prospects for clinical application
Table of Contents
Donor preconditioning and pancreas recovery: Do's and don'ts
Pancreas preservation: Standard and novel methods
Organ allocation: Which pancreas for vascularized pancreas or isolated islet transplant
Islet preservation and preconditioning prior to transplantation
Collaborative islet transplant registry report 2009
Current and future clinical trials
Metabolic studies to assess islet mass and function
Islet transplantation for children: Are we ready?
Clinical research: Results of pancreas transplantation and effects of secondary complications
Risk/benefit ratio of PAK: Is there a case for LD kidney or SPK as the only choice?
The gold standard for T1D and ESRD-SPK
What does the field need for the next wave of creativity?
Protective substances during islet isolation and culture: Myths and facts
Dissecting and predicting islet function after isolation
Islet “graft shaping” and product release criteria: current status and future options
Long term results of steroid free immunosuppression in pancreas transplantation
CNI free immunosuppression in pancreas transplantation
Campath induction - Long term follow-up
Embryonic stem cell-derived beta cells
Endogenous beta cell regeneration
Expansion of adult human beta cells
Mesenchymal stem cells as a source of insulin producing cells
Re-transplantation in 1,000 consecutive simultaneous pancreas-kidney transplants
Renal retransplantation in simultaneous pancreas-kidney (SPK) recipients with functioning pancreatic allografts
Evaluation of pancreas allograft quality and utilization: The pancreas donor risk index
Outcomes in >2,000 pancreas (PX) transplants (TX) at a single institution
Pancreas transplantation in selected type 2 diabetes mellitus recipients
Panel reactive antibodies (PRA) and antibody mediated rejection (AMR) is associated with poor outcomes following pancreas transplantation
Simultaneous pancreas and kidney transplantation in recipients older than 60 years of age
Pancreas transplantation in elderly recipients
Expanded criteria donors in pancreas transplantation: The Oxford experience
Islet autotransplant (IAT) outcomes after total pancreatectomy (TP) in the modern era
Predictiveness of positive C-peptide for outcomes of islet transplantation
Improvement in outcomes of islet transplantation: CITR 1999-2008
Risks and benefits of transplantation in the cure of type 1 diabetes: Whole pancreas versus islet
Influence of donor age on islet isolation and transplantation outcome
Islet allograft survival with ATG induction tacrolimus and mycophenolate mofetil switching to sirolimus and mycophenolate at 6-9 months
Immune mechanisms of teplizumab induction immunotherapy in type 1 diabetic islet allograft recipients
Histological graft assessment after clinical islet transplantation
Pet in clinical islet transplantation
A new method to valued efficiency of enzyme blends for pancreas tissue digestion
Influence of neutral protease concentration on the digestion of collagen VI within the human pancreas
Vitacyte collagenase HA: A novel enzyme blend for efficient human islet isolation background
The effect of truncated collagenase class I isomeres on human islet isolation outcome
Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease
Comparison of liberase HI and collagenase NB1 in 199 human islet isolations
Assessing neutral protease activity in tissue dissociation enzyme mixtures
Novel fluorogenic peptide for evaluating and quantifying bacterial collagenase I, II, thermolysin and neutral protease
Handling and short-term stability of collagenase and neutral protease components and enzyme mixtures
Endoscopic gastric submucosa (EGSM-ITX) islets transplantation in pigs with streptozotocine induced diabetes
Bone marrow as an alternative site for islet transplantation
Prevention of non-immunologic loss of transplanted islets in monkeys
Role of chemokines during IBMIR and development of new therapeutic target
Quantification of transplanted iron oxide-labelled islet cells by 3-dimensional 3T magnetic resonance imaging (MRI)
A strong candidate approach to prevent the instant blood-mediated inflammatory reaction in clinical islet transplantation
Testis specific gene as novel tool for detection of islet damage in the peripheral blood of mice with a portal islet transplant
Prolonged survival of subcutaneous islet allografts in cpnha, an injectable temperature-sensitive hydrogel, with local CTLA4IG and IL1RA
A small molecular GPR119 agonist stimulates beta cell replication and improves islet graft function
Mesenchymal stem cells/BM mediated immunomodulation
Immunomodulation by dendritc cells
Inhibitory signals and T regulatory cells in control of islet allo and autoimmunity
Drug interference in immune regulation
Functional imaging of islet mass
MRI imaging of grafted allogenic islets in transplant patients
PET imaging of islet transplant recipients
Post-transplant new onset diabetes mellitus
Post-transplantation diabetes mellitus - the Giessen Center experience, guidelines and recommendations
Post-transplant osteoporosis
Monitoring islet destruction
Autoimmunity
Consideration of factors affecting chronic islet allograft dysfunction
Recent advances in “ in-vivo” islet imaging
Introduction: does surgery for T2D make sense?
Metabolic surgery for obese patients with T2D
Metabolic surgery for non-obese patients with T2D
Pancreatic transplantation for patients with T2D and ESRD
Overview: risk assessment in xenotransplantation
PERV: donor screening and post-transplant detection
Blocks to retroviral infection: how real is human risk?
Herpes viruses and interspecies infectious risk
Conclusions and discussion
The Transplantation Society — the expanding role: Science, clinical practice, education, ethics and regulations
Pig-to-primate islet xenotransplantation: state of the art
Ethics: safety vs efficacy
Regulatory requirements for clinical xenotransplantation
The role of the WHO and the Changsha communiqué
Progression towards clinical islets xenotransplantation in China
Alemtuzumab induction in simulaneous kidney-pancreas transplantation in the United States: a review of a National Data Registry
Daclizumab (DAC) maintenance therapy in pancreas (PX) transplantation (TX)
Simultaneous pancreas and kidney transplantation from living donors in Japan - Outcome of eleven consecutive clinical trials in a single institution
Simultaneous kidney pancreas transplantation in select patients with type 2 diabetes mellitus having positive C-peptide and negative GAD-65 antibody
Pancreas transplantation from obese donors
Alemtuzumab with rapid steroid taper in simultaneous kidney pancreas transplantation: Comparison to induction with antiyhymocyte globulin
Impact of post-transplant delayed graft function on long-term graft survival in pancreas transplant recipients
Risk factors for delayed graft function after simultaneous pancreas-kidney transplant and its influence on patient and graft survival
Comparative assessment of immunosuppressive regimens in pancreas alone transplantation
Long term outcomes following pancreas transplant patients in a single institution
Kidney-pancreas transplantation in hiv infected individuals: the italian experience
Application of interventional radiology to portal venous thrombosis after pancreas transplantation
Evaluation of coronary microvascular function by coronary flow reserve (cfr) measurement in simultaneous pancreas and kidney transplantation (spk) allograft recipients
Neutrophil oxidative metabolism in diabetic patients undergoing pancreas transplantation
Post transplant diabetes mellitus after pancreas transplantation
Does diabetes have a role in polyomavirus nephropathy development?
Over 500 pancreas transplants in a single-team in São Paulo Brazil
Drugs inhibit rat islet cell proliferation in vitro
Monitoring clinical islet transplantation: Lessons learned from sequential metabolic studies
Glucagon response to hyperglycemia following islet cell transplantation in type 1 diabetes mellitus
Lipotoxicity decreasing islet graft survival
A novel calcineurin inhibitor- and sirolimus-free anti-LFA-1-based therapy enhances allogeneic islet survival and function in nonhuman primates
Inhibition of pro-inflammatory cytokine induced response in human islets by Withaferin A
Morphological and gene expression analysis of human pancreata as a predictor for islet function
In vivo non-viral gene delivery of human vascular endothelial growth factor improves human islet survival and function after transplantation
Module analysis for gene expression in successful single donor islet transplantation
Transcriptome analysis of isolated human pancreatic islets: expression profiles of zinc transporter genes in particular ZnT8 and ZIP14, critical islet marker genes and glucose metabolic genes
Preexisting donor factors and isoltion variables leading to successful islet transplantation from donors after cardiac death
Analysis of clinical course of single donor islet transplantation
Excellence of SUITO index for assessing clinical outcome of islet transplantation
Association between secretory unit of islet transplant objects (SUITO) index and glucose tolerance test after clinical islet transplantation
Metabolic effects of sitagliptin in islet transplant recipients requiring exogenous insulin
Post-transplant chronic anemia in islet transplant recipients is associated with reduced islet graft function and survival
Pancreas persufflation for 6 h and 24 h improves viable islet yields compared with the two-layer method
Pancreas oxygen persufflation increases ATP levels as shown by NMR
A new oxygen carrier improves human islet isolation outcome after prolonged cold storage
Islet isolation from juvenile pig pancreas after 24 h hypothermic machine perfusion preservation: effect of preservation solution and warm ischemia
Comparative impact on islet isolation and transplantation outcome of the new preservation solution IGL-1 vs UW and Celsior
Characterisation of collagenase class I isoforms present in commercially available collagenases used for human islet isolation
Islet isolation from human pancreas with extended cold ischemia time (CIT)
Deliniating the genetic architecture of human islets prepared for clinical transplantation
Collagenase does not persist in human islets following islet isolation
Assessment of human islet isolation with four different collagenases
Retrospective analysis of human islet isolation using roche (Liberase HI and MTF), Serva NB1, and VitaCyte
Toward standardizing islet cell processing protocol the impact of operator variables on human islet isolation
Improved method of human islet isolation for young donors
The standardization of human pancreatic donors for islets isolation: Relation between donor parameters and pancreas structure
Autotransplantation of pure islets from a resected pancreatic remnant with ductal obstruction in chronic pancreatitis
One-layer method with novel compound perfluorohexyloctane increases levels of ATP relative to perfluorodecalin as shown by 31P-NMR spectroscopy
NeuroD1 directs differentiation of cytokeratin 19-positive human pancreatic non-endocrine cells into insulin producing cells
Mesenchymal cells appearing in pancreatic tissue culture are bone marrowderived stem cells with the capacity to improve transplanted islet function
Glucose-responsive insulin production in hepatocytes derived from human embryonic stem cells
Induction of human pancreatic progenitor cells into insulin-producing cells by protein transduction technology
The mechanics of a BAFF-expanded Foxp3+ treg; IL-10 is required for islet allograft tolerance but not treg expansion
PD-1/PD-1l pathway is required for the induction and maintenance of tolerance to neonatal porcine islet xenografts by combined anti-LFA-1 and anti-CD154 monoclonal antibodies
Rapid generation of tolerogenic dendritic cells (TOL-DC) for immunomodulation in clinical islet transplantation
In vivo tracking of “color-coded” effector, natural and induced regulatory T cells in allograft response
CD34+ OCT4+ human pancreatic islet-derived stem cells: endocrine/endothelial features and multidifferentiation potential
An acidic pH and stimulation of phosphoinositide 3-kinase stimulate the differentiation of pancreatic progenitors into the insulin producing cells
Expression of pancreatic endocrine markers by prolactin treated rat bone marrow mesenchymal stem cells
Comparison of adipocyte and bone marrow-derived mesenchymal stem cell as an immune modulator in pancreatic islet transplantation
Expression of human CD39 on mouse islets protects against chemicallyinduced diabetes
Reduced soluable CD30 serum levels early post-transplant correlated with graft survival in islet allograft recipients
Combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induces dominant and CD4+ T cell dependent tolerance to neonatal porcine islet xenografts
Identification of a molecular hierarchy whereby NF-κB blockade prior to transcriptional induction of A20 results in impaired islet function and allograft rejection
The hyperimmunized patient
B-cell immunobiology
What can we learn from ABO incompatible cardiac transplantation in children?
The humoral theory of transplantation
New diagnostic tools
Clinical relevance of anti-HLA antibodies
Clinical relevance of anti-MICA and MICB antibodies
Clinical relevance of other anti-non-HLA antibodies
Role of previous xenografts on the outcome of an allograft
Pathology of antibody-mediated renal allograft rejection
Antibody-mediated rejection: new biological markers
The acceptable mismatch
Desensitization with plasmapheresis and low-dose anti-CMV immunoglobulins
Use of Intravenous Immunoglobulin and Rituximab for the prevention and treatment of antibody-mediated rejection
The hyperimmunized patient in Italy: current status and policy
Successful induction of mixed chimerism and tolerance with non-myeloablative conditioning in mice presensitized with fully mhc-mismatched skin grafts
Pattern of human anti-glycan antibodies as probed with 200 glycans on a microchip
IVIG + single-dose rituximab is an effective desensitization strategy for highly-HLA sensitized patients
A novel algorithm for managing HLA antibodies in sensitized patients awaiting renal transplantation
Is hyperimmunization a risk factor for cancer after kidney transplantation?
New immunosuppressive protocols for islet xenotransplantation
New techniques for islet encapsulation
Alternative sites for islets xenotransplantation
Novel strategies to overcome IBMIR
Central tolerance: The strongest way
Peripheral tolerance: The clinically applicable way
Regulatory T Cells: Minor or major help?
Tolerance to xenoantigens: A goal or an experimental model?
Islet xenotransplantation
Kidney xenotransplantation
Heart xenotransplantation
Lung xenotransplantation
Liver whole organ, auxiliary or hepatocyte xenotransplantation
Risk-benefit analysis for the use of anticoagulation protocols following pancreas transplantation alone (PTA)
Valuable lessons learned in pancreas retransplantation over a 20 year period
Pancreas transplantation from non-heart beating donors in the United Kingdom
Role of pancreas graft biopsies following pancreas transplantation
Stapled duodeno-duodenostomy in pancreas transplantation: A novel technique of enteric drainage
Implications of venous drainage and immunossuppression induction on pancreas transplantation alone
Three-year follow-up of simultaneous pancreas and kidney transplantation from ABO-incompatible living donors
Long-term outcome of pancreas transplantation
Pancreas transplantation in obese recipients
Portal drainage of insulin secrection improves long-term metabolic control in type 1 diabetic recipients
Insulin independence after transplantation of pediatric pancreas in adult IDDM recipients
Simultaneous pancreas-kidney transplantation in china medical university: 25 cases report
Quality of life after simultaneous pancreas and kidney transplantation from living donors - evaluation of both the donors and the recipients using a Short-Form 36 v2
Portal or systemic venous drainage in retroperitoneal pancreas transplantation with enteric exocrine excretion
Incidence of pancreas graft thrombosis in bladder vs enteric drainage
Grade 3 infections after pancreas transplantation remain predominantly bacterial during long term follow up
Long-term efficacy and safety of pancreas transplantation alone in type one diabetic recipients
Comparative study of regenerative potential of beta cell from young and aged donor mice using a novel islet transplantation model
Pancreatic islet Basement Membranes (BMS) are substantially remodelled after transplantation, a process that may regulate allograft rejection
Intra-islet leukocytes and endothelium show an activated phenotype consistent with ischemic/hypoxic stress and impairment of islet endocrine function by paracrine factor production
Localised, cell-mediated immune-privilege in pancreatic islet transplantation
Treatment with exenatide reduces fas expression and enhances β-cell survival and function in human islets during culture: implications for clinical islet transplantation
Cytoprotective effects of deferoxamine on islet cells
18F-Fallypride PET imaging to monitor transplanted islets
Magnetic resonance imaging of transplanted mouse islets labeled with chitosan-coated superparamagnetic iron oxide nanoparticles
Labeling of the pancreatic islets with Gd contrast agent for magnetic resonance imaging and fluorescence microscopy
Prolactin (rhPRL) promotes human beta-cell survival by inhibiting apoptosis
Prolactin (rhPRL) mediated up-regulation of HSP27 and its transcription activation factor hstf1 in human pancreatic islets
The effect of osteocalcin on human islet viabilty, function and beta cells proliferation
Establishing an oygenated fibrin clot system for islet culture
Simple and sensitive quantitative method to assess human islets using a single step reagent to extract ATP, insulin, DNA and protein
The effect of donor BMI on mitochondrial DNA copy number in isolated human pancreatic islets
Molecular evidence for human islet loss of function and de-differentiation post transplantation; a case for islet transplant-toxicity
Viable beta cell mass in human islet preparations does not change during pre-transplant culture
Porcine islet xenograft tolerance is promoted by CD4+CD25+ regulatory T cells
Donor transgenic hCD46 pig islets warrant normoglycemia and long-term graft function in diabetic cynomolgous monkey recipients, using limited immunosuppression
Expression of human CD39 on mouse islets protects against chemically-induced diabetes
A Scoring to evaluate the function of islet grafts in a primate preclinical model
The evidences of induced autoimmue diabetes in primates: establishment of a preclinical large animal model of T1DM
Diabetic rats and mice are highly resistant to porcine insulin: flawed experimental models for testing porcine islet xenografts
Combination of immunosuppressive therapy in adult porcine islet xenotransplantation into non-human primate
Validation of human insulin, proinsulin and C-peptide elisas for analysis of non-human primate samples and sensitive analysis of changing insulin responses to glucose during deteriorating beta cell function
Comparison of single high-dose STZ with partial pancreatectomy combined low-dose STZ for diabetes induction in rhesus monkeys
In vivo assessment of functional beta cell mass in macaques
Common marmoset monkeys - a new world primate model for diabetic research - a comparision with human pancreatic islets
Perfluorocarbon-biodritin macrocapsules and their potential for type 1 diabetes mellitus therapy
Beneficial effects of desferrioxamine on encapsulated human islets - in-vitro & in-vivo study
SLM alginate 3% v/v is optimal for a subcutaneous pig islets monolayer cellular device
Intramuscular transplantation of microencapsulated pancreatic islet cells in barium crosslinked ultra-high viscosity alginate
Life supporting xenogeneic islet transplantation with a regimen including hepatocyte growth factor in a clawn miniature swine-to-cynomologous monkey model
Embryonic pig pancreatic tissue as a β-cell replacement therapy for diabetes
Long term survival and function of porcine islets co-transplanted with adult porcine sertoli cells into non-immunosuppressed rats and mice
Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in xenogeneic islet transplantation
Enhanced prediction of porcine islet yield and post-transplant outcome through combining quantitative histomorphometrical parameters and flow cytometry analysis
Combination of simvastatin and JNK inhibitor improved beta-cell viability index of porcine islet without enhancing in vivo islet potency
Fibrin beyond the carrier for subcutaneous islet transplantation; Superior hyperglycemia control with reduced islet marginal mass by promoting islet viability and local angiogenesis
Development of a novel, rapid and accurate pre-transplant in vitro assay to determine the in vivo function of transplanted islets of langerhans
Transgenic expression of three antioxidant enzymes protects mouse islet allografts from rejection
Novel approach to promote neovascularization with endothelial like-MSC-coated islet
Long-term normoglycaemia in adult pigs following porcine neonatal islet cell cluster transplantation
Characterization of the cell composition and function of islets isolated from different ages of newborn pigs
Genetic modifications for pig-to-primate transplants
Impact of thrombocytopenia on survival of baboons with genetically-engineered pig livers
Early graft failure of gtko pig organs in baboons is reduced by hCPRP expression
Tissue factor expression (TF) on recipient platelets initiates consumptive coagulopathy (CC) in pig-to-primate kidney transplantation (Tx)
Early cardiac function and gene expression after orthotopic cardiac xenotransplantation
B cell depletion by anti CD20 prolongs GalKO.hCD46 pig heterotopic cardiac xenograft survival in baboons
Hepatic function and coagulation after genetically-engineered pig liver transplantation in baboons
Histopathology of wild-type and genetically-engineered pig liver xenografts in baboons
High levels of cytotoxic anti-non Gal preformed natural antibody did not induce hyperacute rejection but did cause early graft loss in a GalT-KO pig-to-baboon thymokidney model
Improved survival of GalT KO/hCD55-hCD59 pig renal xenografts in non-immunosuppressed baboons
Prolonged survival of GalT-KO swine skin on baboons
Xeno-metanephros as a biocompetent scaffold for kidney regeneration
hHO-1 overexpression in transgenic pigs reduces ischemia/reperfusion injury after acute myocardial infarction
The role of T cells, NK cells, complements, and gal antigen in acute rejection after pig-to-mouse corneal xenotransplantation
Xenotransplantation of human myoblasts in SCID mice as a model to observe the formation of donor-derived satellite cells
Failure of monkey bone marrow mesenchymal stem cells to develop myogenic potential after intramuscular xenotransplantation in SCID mice
Influence of defibrotide on cardiac function and myocardial damage in an ex vivo xenogeneic perfusion model
Increased direct and indirect anti-donor CD4 T cell responses and inflammatory serum cytokines early posttransplant leads to rejection of islet xenografts in pig-to-monkey model of islet transplantation
Prevention of the adaptive immune response after alpha-1,3-galactosyltransferase gene-knockout (GTKO) pig artery transplantation (Tx) in baboons
hCD46 inhibits complement pathway amplification during Gal-TKO pig lung perfusion with human blood
Porcine nectin-2/CD112 expressed on the endothelial cells triggers human NK cytotoxicity by dnam-1
Quantification of baboon thymopoiesis in porcine thymokidney xenografts by a signal joining TCR Excision Circle (sjTREC) assay
Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T cells in non-human primates
Ex-vivo expanded CD4+CD25+ treg cells inhibit the proliferation of B cells
Microarray analysis of changes in porcine orthotopic cardiac gene expression
Efficiency of genetic modifications to prevent antibody/complement- and cell-mediated lysis of pig cells
Soluble activated human protein c mutes thrombin formation in GalTKO pig lung xenograft rejection
Adipose-derived mesenchymal stem cells (AT-MSC) suppress xenoantibody production
Short-term treatment with FTY720 after concordant xenoheart transplantation impairs the T-independent IgM Xab response, preventing acute rejection but not chronoic vasculopathy
The role of CD39, CD73 and purinergic signalling in renal ischaemia reperfusion injury
Mechanism of xenograft microangiopathy
hCD39 and hTFPI. What other transgenes should be inserted in the donor pig?
What anticoagulant therapy should be given to the recipient?
What antiplatelet therapy should be given to the recipient?
Consumptive coagulopathy and the role of extensive coagulation monitoring in xenotransplantation
Macrophages, dendritic cells
NK, NK T cells
Complement regulation in the GaIT KO era
Toll-like receptors/CD47
Inventory of xenotransplantation practices
Submission of an application of a clinical trial of xenotransplantation to the health authorities
Global network of laboratories involved in xenotransplantation safety
Non-Gal antibodies: the anti-protein response
Absence of isoglobotrihexosylceramide 3 and the αgal xeno-antigen in endothelial cells derived from α-1,3galactosyltransferase knock out (galtko) pigs
Expression library identification of endothelial cell membrane non-gal antigens detected by antibody induced after pig-to-primate cardiac xenotransplantation
A wider repertoire and increased titers of carbohydrate-specific antibodies in mice rejecting adult porcine islets
N-glycolylneuraminic acid is recognised by naturally occurring cytotoxic human xenoantibodies
Anti-hyaluronan antibodies: the next challenge in pig organ xenotransplantation
Does addition of CTLA4Ig to an anti-CD154-based regimen prevent anti-non-Gal antibody production after GalTKO or GalTKO/hCRP pig organ xenografting?
Reduced calcification of glutaraldehyde-treated pericardium from cloned gal knockout pigs: effects of anti-gal antibody in the rat model
Significant dampening of anti-non-gal antibody responses in splenectomized baboons following b cell depletion authors
Complement fixation and follicular dendritic cell pickup of αgal immune complexes are critical for induced anti-gal humoral responses
Structural characterization of α1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies
Thrombin activation in α1,3-galactosyltransferase gene-knockout (gtko) xenograft recipients and its relevance to the primate immune xenoresponse
Humanized monoclonal antibody 6B4 Fab inhibits GP1B-vWF-mediated human platelet aggregation by porcine plasma
Pharmacological intervention in xenoperfused porcine kidneys. effect of TNFantibody on coagulopathy and endothelium
Anti-inflammatory properties of human thrombomodulin provide additional beneficial effects on coagulation control
Fgl2 induction in porcine endothelial cells through xenogeneic CD40-CD40L interaction
The adaptor Lnk: a novel regulator of signaling that controls inflammation and endothelial cell survival and a candidate to prevent vascular dysfunction in xenotransplantation
Hypercoagulable whole blood rotation thromboelastometry (ROTEM ® ) profile in 40 cynomolgus monkeys
Coagulation profile in cynomolgus monkey recipients of porcine neuronal xenograft: a preliminary study
Whole blood coagulation assessment using rotational thromboelastometry (ROTEM) following administration to primate of carbon monoxide releasing molecules in primates
Comparison of thrombin generation between humans and cynomolgus monkeys
Genetic engineering of the donor species: current status
Multi-gene Constructs to Accelerate the Generation of Multi-transgenic GalT knockout pigs
Generation and characterization of human hemeoxygenase-1 (hHO-1) transgenic pigs
Multi-transgenic pigs designed for xenoislet transplants
Locally expressed ICOS-Ig prolongs cellular xenograft survival
Endogenous thrombomodulin is sufficient for the protective effect of epcr overexpression on ischaemia-reperfusion injury
Site-specific expression of human thrombomodulin on porcine endothelium
Transgenic strategies to overcome cell-mediated and acute vascular rejection in pig-to-primate xenografts
Production and characterization of hA20-transgenic pigs suitable for xenotransplantation
Engineering of immunomodulatory pigs for xenogeneic islet transplantation
Production and function of soluble marmoset icos-Ig
Production of multi-gene transgenic pigs by sperm-mediated gene transfer for xenotransplantation
Key ethical issues in xenotransplantation
Current Regulatory System for Xenotransplantation Research in Korea
A survey of the attitude of scientists toward Xenotransplantation in Taiwan
A Study on the Korean People's Attitudes toward Xenotransplantation
A health-economic analysis of porcine islet xenotransplantation
Improved welfare of nonhuman primates used in Xenotransplantation: beneficial effect of peripherally placed central vascular access ports (vaps) in conjunction with cooperative handling
A multi-centre study of attitude towards Xenotransplantation in a region with a preclinical solid organ xenotransplantation programme
Xenogeneic infection risk and restriction of individual rights: an European approach (EU, German, Spanish and English Law)
Are veterinary students in favour of Xenotransplantion? An opinion study in a spanish university with a xenotransplantation program
Porcine Xenotransplants in the primate brain as a model to study immune and neuroinflammatory responses following intracerebral implantation
Detection of cmv-related gastrointestinal tract infections in a series of 49 xenotransplanted primates
Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit?
Telemetry is an effective means to evaluate transplanted heart function in experimental heterotopic cardiac xenotransplantation
Monitoring of microvascular perfusion with orthogonal polarization spectral imaging during pig to baboon cardiac xenotransplantation
The possible use of Muticolour FACS analysis based on CD95-positive marker for immune monitoring of rhesus monkey
Anti-Gal antibodies: a model for anti-carbohydrate response
Xenoantibodies to non-α gal antigens in baboons do not target pig proteins
The carbohydrate specificity of different α-Gal reagents determined by a glycolipid chromatogram binding assay. A complete lack of α-Gal glycolipid reactivity in GalT-KO pig small intestine
Insulin resistance and the presence of thymus-independent anti-insulin IgG antibody production
Lack of MHC specificity of induced anti-pig antibodies in porcine cellimmunized mice
Lectin microarray analyses of cells from the α1-3galactosyltransferase knockout pig
Impact of hypothermia and cardioplegic solutions on the α-gal epitopes on porcine aortic endothelial cells
Microbial Safety in Xenotransplantation
PERV-A receptors in non-human primates: implication for their employment as an animal model for xenotransplantation
The vascular origin of porcine endothelial cells influences human cytomegalovirus replication
Tetherin overexpression reduces PERV release from pig cells
PERV-C integration, expression and transmission of perv to human cells: is there a link?
Epigenetic and transcriptome-wide approach to the identification of active porcine endogenous Retroviruses
Long-term characterisation of transgenic pigs expressing PERV-specific shRNA with knock-down of porcine endogenous retroviruses (PERVs)
Expression of complement regulatory protein on porcine endogenous retrovirus depends on molecular size
Infectivity of human herpesviruses (HHV) 1, 2, and 5 to porcine cells
Over-expression of HLA molecules on porcine endothelial cell surface interferes with HCMV entry and replication
Immune correlates in operationally tolerant human graft recipients
GTKO pig mesenchymal stem cells ( p MSC) - characterization, differentiation, and modulatory effect on the human and baboon immune responses
Downregulation of cellular immune responses to porcine xenoantigen by targeting PD-1/PD-ligand pathways
MHC class I ligation regulate phase II genes through PI3K/AKT activation, and enhances protection of endothelial cells from complement attack
Ex vivo expanded non-human primate regulatory t cells suppress xenoantigenic responses through both cytokine-and contact-dependent pathways
Roles of Toll-like Receptors on Islets in Xenogenic Islet Transplantation
CD47 expression on donor cells is required for tolerance induction by combined DST and CD154 MAB treatment in a mouse model of heart transplantation
IL-10 is required for human CD4+ CD25+ regulatory T cell-mediated suppression of xenogeneic response
FOXP3 regulates human natural CD4+ CD25+ regulatory T cell-mediated suppression of xenogeneic response
TNF, PIG CD86 AND VCAM-1 identified as potential targets for intervention in xenotransplantation of pig chondrocytes
A splice variant of porcine tumor necrosis factor receptor 2 lacking exon 4 regulates tnf activity
Implications for xenotransplantation of a soluble variant of porcine tumor necrosis factor receptor 2
Effect of sirolimus versus mycophenolate mofetil on glucose metabolism in pancreas and kidney transplantation: a prospective randomized study
Hand-assisted laparoscopic living donor nephrectomy and distal pancreatectomy for simultaneous pancreas and kidney transplantion
Unusual presentation of post-transplant lymphoproliferative disorder in two pancreas transplant recipients
Reduced B7-H4 expression in human beta cell is associated with recurrent type 1 diabetes in a failed pancreas allotransplant
Kidney pancreas transplantation with simultaneous allograft nephrectomy for recipients with prior renal transplant lost to BK nephropathy
Efficacy of pancreas transplantation: impact on severe hypoglycemia, diabetic ketoacidosis and glycemia related end points
Poor glycemic control following renal transplantation in type I diabetics: a call for increased utilization of pancreas after kidney (PAK) transplantation
Pancreas autotransplantation combined with total pancreatectomy for recurrence of pancreatic cancer: a case report
Celsior versus Wisconsin solution in pancreas transplantation
Intraabdominal bleeding following simultaneous pancreas-kidney transplantation treated with angiographic embolization
Pancreatic islet cells antibodies in diabetic patients submitted to pancreas transplantation
One hundred pancreas transplants at a brazilian institution
Ten years experience with partial extraperitoneal placement of enteric drained pancreas transplant
The outcome of pancreas transplantation from marginal donors in Japan
Efficacy of immediate post-transplantation CT angiography in pancreas transplantation
Epidermal nerve fibres in pancreas transplant recipients: follow-up after 2.5 years of normoglycemia
Surgical complications in simultaneous pancreas and kidney transplantation (SPK) with enteric exocrine drainage and systemic venous drainage
Percutaneous embolization of peri-duodenal varix due to portal hypertension in a patients with kidney-pancreas transplantatation
Analysis of inhaled anesthetic agents in pancreas transplantation
Is there a benefit of induction therapy and calcineurin inhibitor postponing?
Surgical technique video description of retroperitoneal placement of pancreas graft with portal-enteric drainage
Pancreas transplant alone in child: a case report
Simultaneous pancreas-kidney transplant in a HIV recipient - case report
Pancreas allograft preservation with UW alone or mixed solutions for donor aorta flush - is there a difference?
Results of islet autotransplantation after extended pancreatectomy for benign disease of the pancreas and their significance for live donation
Islet function is similar in alloislet and autoislet transplant recipients, despite the lower islet mass of islet autotransplants
ET-Kyoto ductal injection and density adjusted purification combined with potent anti-inflammatory strategy facilitated single donor islet transplantation
Super high dose islet transplantation is associated with high SUITO index and prolonged insulin independence
Pancreatic ductal preservation imroves islet isolation outcome in autologous transplantation for chronic pancreatitis
Influence of autoimmunity in clinical islet transplantation evaluated by type 1 diabetes-specific auto-antibodies
Immune monitoring in clinical islet transplantation by assessment of induced-activation of CD4+ T-lymphocytes
Initiation of a islet isolation program in The Netherlands
Kyoto islet isolation method allows efficient islet retrieval from young donor pancreas for clinical use
Effects of exercise on glucose homeostasis in clinical islet transplantation
Exendin-4 in addition to tacrolimus improves viability in cultured beta cells
Induction with single dose alemtuzumab subcutaneously in simultaneous kidney pancreas (SPK) transplantation
AMT, an inducible nos inhibitor, attenuates neogrowth and prolongs graft survival of alginate-poly-L-lysine-alginate microencapsulated islets
Successful pancreas-renal transplantation without induction therapy
Mediated expression of the immunomodulatory molecule PD-L2 in human islets maintains stable in vitro islet function
Lower rate of acute rejection with rapamycin vs mycophenolate mofetil in simultaneous pancreas-kidney transplant recipients: 8-year follow-up
Bortezomib spares plasma cells protective for tetanus toxoid during removal of HLA antibodies
The solidarity of science and self-sufficiency: why efforts to enhance organ donation should remember the needs of research
Ethical issues involved in xenotransplantation: current trends
Transforming growth factor beta 1 (TGF-β1) and rapamycin synergize to inhibit TCR-induced human CD4+ and CD8+ T cell proliferation
Identification of novel parasite-derived compounds that promote long-term islet allograft survival
Effect of costimulation blockade treatment on allogeneic islet graft survival in the alloimmunized mice
Resistance of diabetes in aged nod mice is mediated by CD4+CD25+FOXP3+ Regulatory T cells
Hormone resuscitation of BD porcine donors reduces pancreatic inflammation
Anti-CD45RB therapy effectively prevents the rejection of islet allograft by islet-reactive CD4 and CD8 cells in a TCR transgenic model
Hyperbaric oxygen therapy prevents autoimmune diabetes onset in NOD mice
Comparison of fresh and cultured islets from human pancreata
Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture
Culture of impure human islet fractions in the presence of alpha-1-antitrypsin prevents insulin cleavage and improves islet recovery
In vitro effects of IGF-1 on Human Islet function and quality
Use of human serum or human albumin for human islet culture
Together they can: escaping anoikis by establishing cell-cell contacts in the human pancreatic cell line “hPan”
Visualisation of mitochondrial heterogeneity in stressed human pancreatic cells
Islet transplantation in pre-vascularized collagen chambers placed subcutaneously or in the omentum: a comparative study
Surface modification of islets with PEG-lipid for improvement of graft survival in intraportal transplantation
Effect of diabetes on oxygenation and neovascularization for subcutaneous encapsulated islets
The theracyte device protects islet allografts in the immunized host
Pre-implantation of cell encapsulation devices allows for greater survival of transplanted cells
Islet transplantation using macroencapsulation device
Evaluation of tolerance induction and reversal of autoimmunity by porcine thymus and islet xenotransplantation in NOD mice
Improved method of porcine pancreas procurement with arterial flush and ductal injection enhances islet isolation outcome
The road to successful islet xenotransplantation
Rapid quantitative assessment of the porcine pancreas biopsy predicts islet yield
The age of porcine sertoli cells is critical for providing immune protection of porcine islets xenografted into rats and mice
Xenotransplantation of microencapsulated porcine islet cells in diabetic rats
Creating a prevascularized site for islet transplantation using a V.A.C.®-GranuFoamTM and HBO in rats
In vivo increase of alpha cells in pig islets by low dose of stz improves insulin secretion
The effects of glucagon-like peptide 1 (GLP-1) and gastrin on the proliferation and differentiation of neonatal pig pancreatic cell clusters (NPCCs)
Long-term culture of neonatal islet cell clusters demonstrates better outcomes for reversal of diabetes
Comparison of the portal vein and hepatic artery as sites for pig islet xenotransplantation in non-human primates
Gene expression profiling of cytotoxic lymphocytes and islets in the peripheral blood for monitoring of portal islet transplants in streptozotocin-diabetic mice
Comparison between ferucarbotran (Resovist®) and ferumoxide (Feridex®) in human islet graft monitoting
Vascularization of PPL (polypropylene) chambers for islet implantation assessed by Magnetic Resonance Imaging (MRI). A preliminary data
A novel technique to surgically implant a polypropylene scaffold into the omentum for the transplantation of pancreatic islets
Novel aspect of experimental islet transplantation: investigation of desirable trasplantation sites and production of diabetes model pig
Biocompatible, 3-dimensional, cyclic RGD-modified, purified alginate scaffold designed to enhance islet viability, neovascularization, and efficacy of extrahepatic islet transplantation
Co-transplantation of rat endothelial progenitor cells to enhance the engraftment of pancreatic islets
Islet transplant engraftment and function: a potential role for rosiglitazone
Fabrication of functional islet-cell sheet
Exendin-4 stimulates beta-cell replication in mouse adult islet grafts but not in human adult islet grafts in mice
Transgenic expression of insulin-like growth factor-II (IGF-II) in pancreatic islets to prevent apoptosis
IBMIR: in vitro study of role of rapamycine on macrophage activation during islet transplantation
Identification of new therapeutics targets to increase islet vascularization during transplantation
Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans
Role of CCL2/MCP-1 in islet transplantation
The anterior chamber of the eye allows performing noninvasive, repeated live imaging of islet allograft rejection
Prolonged allogeneic islet graft survival into a prevascularized, subcutaneous biohybrid device
Lack of cytoprotection of gabexate mesylate on pancreas cold preservation and islet cells
Noninvasive, live imaging studies of human islet cell biology in the anterior chamber of the eye
Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats
Comparison of adipocyte and bone marrow-derived mesenchymal stem cell as an immune modulator in pancreatic islet transplantation
The application of luciferase transgenic rats for experimental islet transplantation model
Non-invasive imaging to monitor pancreatic islets function
Imaging of human islets vascularization using a dorsal window model
Islets purified by differential osmotic shock maintain normal distribution of cellular subpopulations and electrical coupling
Improvement of pancreatic islet cell isolation from NHBD: 15 cases report
Effect of cold ischemic time on rat islet yield
Effect of cold ischemic time on islet yield and function
Establishing a clinical islet program with a quality management system in Australia
Comparison of Australian donor, pancreas and preparation characteristics of transplanted and non-transplanted human islet preparations
Peri-insular laminin within pancreases of young human donors is not resistant to collagenase digestion
The impact of ischemic stress on the quality of isolated pancreatic islets
Comparison of Human islet isolations with or without the use of Desferrioxamine (DFO)
Comparison of donor variables and islet isolation outcomes using liberase and serva enzymes
Comparative study on enzymatic activity and molecules stability of some commercial proteolytic enzymes used in pancreatic islet isolation
Glucose and Oxygen Supplements in UW Solution Improve Islet Isolation Outcome
MRI as a novel tool to develop new methods of pancreas distension to enable homogeneous enzyme distribution for successful islet isolation
Comparison of HTK and UW preservation solutions for clinical pancreas transplantation: an update of the Indiana University experience
Continuous, real-time viability assessment of pancreata based on oxygen consuption
Ex-vivo expansion of adult human pancreatic islet beta cells
Assessment of the differentiation potential of human adult pancreatic islets derived progenitor cells in mice
Report from Argentina of first three years follows up of autologous stem cells implant in diabetes type 1 (World Wide Pioneer experience)
First report from Argentina of first three years follows up of autologous stem cells implant in diabetes type 2
“Stemness” properties of in vitro long-term cultured human islet cell monolayers
Reprogramming spleen into pancreas: a novel study of the molecular mechanisms behind splenic mesenchyme-to-epithelial transition
Correction of diabetes in mice following transplantation of an insulin-secreting human liver cell line
Regression of diabetic complications by singenically transplanted rat pancreatic islets
Effects of pancreas transplantation on oxidative stress in pulmonary tissue from alloxan-induced diabetic rats
Pancreas transplantation prevents morphological and ultrastructural changes in pulmonary parenchyma of alloxan-induced diabetic rats
Effective treatment of metastatic insulinoma using multiple treatments with systemic rna interference targeting mouse pdx-1 in a mouse insulinoma model
Photochemical pathogen activation of human serum enables its large-scale application in clinical islet transplantation
RNA interference targeting mouse pdx-1 gene corrects hypoglycemia in somatostatin receptor 1 and 5 knockout mice
Fluid intake, volume overload, hypertension and body composition in indian renal transplant patients
Near normoglycemia in rats achieved by immune protected and oxygenated islets of langerhans
Post-transplant processing of superparamagnetic iron nanoparticles used for islet labeling and MR detection
Transplantation of annular pancreas grafts. report of two successful cases
The age of porcine Sertoli cells is critical for providing immune protection of porcine islets xenografted into rats and mice
Xenotransplantation of microencapsulated porcine islet cells in diabetic rats
Creating a prevascularized site for islet transplantation using a V.A.C.®-GranuFoamTM and HBO in rats
In vivo increase of alpha cells in pig islets by low dose of STZ improves insulin secretion
The effects of glucagon-like peptide 1 (GLP-1) and gastrin on the proliferation and differentiation of neonatal pig pancreatic cell clusters (NPCCs)
Long-term culture of neonatal islet cell clusters demonstrates better outcomes for reversal of diabetes
Comparison of the portal vein and hepatic artery as sites for pig islet xenotransplantation in non-human primates
Ultrasonography to quantify renal perfusion of hDAF pigs xenografts transplanted to Macaca cyclopis monkeys
Ex vivo porcine renal xenotransplantation model using a pulsatile machine preservation system
Using Macaca cyclopis as a primate model to study xenotransplantation of porcine kidney with hDAF transgene
Surgical and non surgical complications of a pig to baboon xenotransplantation model
Pig xenogenic adipose-derived mesenchymal stem cells for bone reconstruction
Airways homing of human amniotic fluid stem cells and repair in newborn rats exposed to hyperoxia
The in situ Langendorff model: a new method for AAV2/9-mediated gene transfer into myocytes in heterotopic heart transplantation models
Potential role of complement activation on rejection of xenogeneic pig chondrocytes
The free radical scavenger S-PBN reduces human leukocyte migration across porcine endothelial cells
Role of HMGB1 in lung xenograft injury and cytokine production
Characterization of human and mouse cytokine profiles in xenogeneic lung injury
Imaging heterotopic cardiac transplants in rodents
Chronic immunosuppression with tacrolimus is associated with an increased risk of drug-induced diarrhea post islet xenotransplant in cynomolgus macaques
Human platelet lysate expanded mesenchymal stem cells promote rapid commitment of CD34+ progenitor cells
Continuous, real-time viability assessment of kidneys based on oxygen consumption
Lewis, Duffy and Kidd system prevalence in baboon subspecies and pigs
ABO blood group phenotyping in pigs using microtyping cards
Pig anti-baboon antibodies tested at different pig's ages
Xenotransplantation and coagulation disorders: different levels of human activated protein C in human and porcine endothelial cells
Correlation between xenoreactive antibodies and xenogenic activation of the coagulation system in xenoperfused pocine kidneys
Towards the generation of human TFPI transgenic pigs with improved features for xenotransplantation
Comparison of procoagulant phospholipids levels between human and cynomolgus monkeys
Human thrombomodulin plays an important role in coagulation control: engine braking is essential for physiological regulation
Activation of human protein C by α1,3-galactosyltransferase gene-knockout porcine aortic endothelial cells expressing human thrombomodulin
Analysis of transgene expression in transfected somatic pig cell to be used as donor in nuclear transfer
An episomal vector containing the ecto-5′-nucleotidase gene
Double transgenic Gal-/- piglets over-expressing hCD39
Significant differences of some physiological parameters in humans and pigs
Production of transgenic mini-pigs with membrane-bound human FasL by somatic cell nuclear transfer
Study of the attitude of Scottish citizens toward xenotransplantation in the South East of Spain
Refinement of a primate xenotransplantation model: application of a subcutaneously implanted port as a means of gastric nutrition
Improvement of analgesic protocols in renal xenotransplantation procedures
Xenovirology monitoring: tasks and issues
Animal model sysyem of PERVs transmission in xenotransplantation using pig's organ
Assessment of the potential risk of infection associated with clostridium difficile from porcine xenografts
Hepatitis E virus: a potential risk for xenotransplantation?
Suppressor of cytokine signaling transcription in human cytomegalovirusinfected porcine endothelial cells
Isolation of human CD4+ lymphocytes from spleens of pigs with minimal chimerism
Porcine MIC2 does not trigger human NKG2D-dependent cytotoxicity
Successful induction of mixed chimerism and tolerance with non-myeloablative conditioning in mice presensitized with fully MHC-mismatched skin grafts