About the International Xenotransplantation Association
Multi-transgenic pigs for vascularized pig organ xenografts
Islet-specific expression of TFPI, CD39, and CTLA4Ig in transgenic pigs designed for xenoislet transplantation
Relative efficiency of porcine and human CTLA4-Ig in inhibiting human CD4+ T cell responses costimulated by porcine and human B7 molecules
Over-expression of human HO-1 and A20 in porcine cells: Effects on susceptibility to cell-mediated lysis and inflammatory cytokines
A comparison of the in vitro human immune response to corneal cells from humans and genetically-modified pigs
Zinc-finger nuclease mediated knockout of the porcine α1,3-galactosyltransferase gene
Successful production and breeding of cloned pigs expressing human thrombomodulin in endothelial cells
GalT-KO/CD46/hTM triple-transgenic donor animals for pig-to-baboon heart transplantation
Miniature swine expressing human CD47 to enhance bone marrow engraftment in non-human primates
LEA29Y transgenic pigs for overcoming cellular rejection in xenotransplantation
Induced T regulatory (iTreg) cells suppress T and B cell immune responses
Blocking porcine sialoadhesin improves extracorporeal porcine liver xenoperfusion
T cell-directed immunosuppression is associated with downregulation of thrombin activation, but upregulation of inflammatory responses in xenograft recipients
Comparison of Gal and non-Gal mediated cardiac xenograft rejection
Novel experimental models to test human NK cell recruitment to porcine endothelium and their role in cellular xenograft rejection
T cell-directed immunosuppressive therapy prevents development of natural anti-AB and anti-pig antibodies in infant baboons
Human xenogeneic immune responses to HD antigen in xenotransplantation
Difference in signal transduction between anti-A/B and anti-HLA antibody binding to endothelial cells
Roles of B cells and Tregs in anti-CD45RB induced transplant tolerance to islet xenografts
Study of complement activation in a life supporting pig to primate xenotransplantation model using GAL KO pigs
Rat-elicited anti-carbohydrate xenoantibodies cross-react with cells of multiple species and bacteria
Gal-deficient porcine neonatal islets that express human CD55 and CD59 are protected from IBMIR in a baboon model
Gal-knockout pigs transgenic for hCD46 and islet-specific TFPI/pCTLA4Ig have normal glucose metabolism and isolated islets exhibit normal glucose and arginine responses and should be considered as donors for islet xenotransplantation
Beta-Air®, a subcutaneous implantable, oxygen supported, bio-artificial pancreas, restores glycemic control in xenogeneic diabetic mini-pig model
Islets and mesenchymal stem cells co-encapsulation can improve subcutaneous bioartificial pancreas survival in diabetic primates
The impact of heme oxygenase-1 (Ad-HO-1) on apoptosis of neonatal porcine cluster cell (NPCC)s and generation of human HO-1 transgenic pigs
Prolongation of xenoegeneic islet function using an HGF-based immunosuppressive regimen in a CLAWN miniature swine-to-cynomologous monkey model
Function of microencapsulated adult porcine islet xenografts in streptozotocin-diabetic non-human primates
Instant C3a generation after intraportal porcine islets xenotransplantation in non-human primate is dependent on alternative complement pathway activation
Evaluation of various purified components in the development of an application-specific enzyme formulation for the isolation of porcine islets
In vitro and in vivo function of macroencapsulated adult porcine islets is enhanced by changes in the capsular matrix microenvironment
No evidence of PERV infection in diabetic patients in 12 years after islet xenotransplantation
Emerging pathogens of concern in xenotransplantation
The hepatitis E virus does not appear to be transmitted via xenotransplantation
Does PERV transmit to recipient's spouse and their offspring?
Reduction of the expression of porcine endogenous retroviruses (PERVs) in transgenic pigs by RNA interference: new studies
Mechanism and immunological consequences of human cytomegalovirus entry into porcine cells
PERV-C integration, expression and transmission of PERV to human cells
CpG hypomethylation as a marker of transcriptionally active porcine endogenous retroviruses
No long-term transmission of PERV in fifty five patients receiving porcine skin xenografts
Porcine endogenous retrovirus (PERV) Integration in the pig genome
Long-term cardiac xenograft (pig to baboon) survival is correlated with presence of increased percentage of CD4+CD25HiFoxP3+ T regulatory cells
IL-10 is required for the prevention of islet xenograft rejection by ex vivo-expanded human regulatory T cells in a humanized mouse model
Tolerance, function and homeostasis of human T cells, including Tregs, developing in pig thymus xenografts
Induction B-cell depletion, but not CD28/B7-directed costimulation blockade, prevents induced anti-non-Gal antibody responses after GalTKO.hCD46 cardiac xenotransplantation
Non-human primate natural and induced regulatory T cells suppress proliferative response to WT pig cells
Allo- and xenotransplantation of artery patch grafts in infant baboons: can T cell tolerance be expected?
Hirudin reduces upregulation of CD86 and the human T cell response to thrombin-activated pig endothelial cells
Chemoattractant signals and adhesion molecules promoting human regulatory T-cell recruitment to porcine endothelium
Role of immune modulation by Sertoli cells for surviving xenotransplantation
Fetal injection of human MSC's as a method for xeno-tolerization
Transplantation of encapsulated porcine hepatocytes improves metabolic function and survival in baboons with acute liver failure
Xenotransplantation of porcine CTLA4-Ig+/+ neural precursors enables recovery of the locomotor activity in parkinsonian primates
Heart xenotransplantation using genetically-engineered pigs: can CTLA4-Ig replace anti-CD154mAb in the immunosuppressive regimen?
Nonhuman primates may fail to serve as an adequate model for studying extracorporeal porcine liver perfusion
Lamellar corneal xenotransplantation using decellularized porcine cornea showed long graft survival in Rhesus macaques
Limitations of the model of porcine islet transplantation in diabetic nonhuman primates affecting long-term survival and graft function
Consistent survival up to 19 days in a heterotopic thoracic pig-to-baboon cardiac xenotransplantation model
Gal Kock-out pig islets can modulate the humoral response after the transplantation of macroencapsulated pig islets in diabetic primates
Neuroprotective properties of Marrow-Isolated Adult Multilineage-Inducible (MIAMI) cells in rat hippocampus following global cerebral ischemia are enhanced when complexed to biomimetic microcarriers
Rituxan and co stimulation blockade based immunosuppression effectively prevents pig cardiac xenograft rejection in baboon for up to 8 months
Combined GPIb and GPIIb/IIIa blockade prevents sequestration of platelets in a pig-to-human lung perfusion model
Elevated C-reactive protein and IL-6 levels precede consumptive coagulopathy in GTKO pig organ xenograft recipients
Integrin dependent baboon platelet activation and phagocytosis by porcine hepatocytes and endothelial cells
Where do platelets go after pig-to-baboon liver xenotransplantation? Evidence for platelet-WBC aggregation
Immunosuppressive therapy is associated with upregulation of tissue factor expression on innate immune cells and their aggregation with platelets in xenograft recipients
Inhibition of tissue factor prolongs intrahepatic islet xenograft survival in diabetic SCID mouse model
Alterations in the coagulation profile of primate recipients of a life-supporting renal xenograft from a α1,3-galactosyltransferase gene-knockout (GTKO) pig
Functional difference between membrane-bound and soluble human thrombomodulin
Comparison of thrombin generation in transplanted primates recipients of pig hDaf or hDaf-GalT-KO kidney
Complement and thrombin block endothelial cell accommodation
B cell depletion synergizes with ECDI-fixed rat splenocyte infusions to induce concordant rat to mouse islet xenotransplantation tolerance
Caprine pancreatic islets xenotransplantation into diabetic balb/c mice: a new challenge in diabetic xenotransplantation research
Long-term cultured neonatal islet cell clusters demonstrates better outcomes for reversal of diabetes in-vivo shown by their molecular profiling
Complement is not activated at the graft site in non-immunosuppressed immunocompetent mice transplanted with GTKO/hCD46 pig pancreatic tissue
Comparison of enzyme efficiency in porcine islet isolation and in vitro maturation from young pigs
Development of chimera recombinant collagenases G and H for the isolation of islets of Langerhans
Long-term survival of neonatal porcine islet xenografts co-transplanted with Sertoli cells and combined treatment with anti-LFA-1 monoclonal antibody
The effect of costimulation blockade on memory T cell responses in a rat- to mouse islet xenotransplantation model
Humoral rejection in xenogeneic IBMIR: plasma causes membrane damage, mitochondrial dysfunction, and cell death in pig pancreatic islets
SIRPA interspecies incompatibilities lead to xenogeneic phagocytosis of platelets by liver cells
Activated protein C levels generated by GalT-KO PAEC expressing human endothelial protein C receptor and thrombomodulin in the early stage of interaction with human protein C and thrombin
ASGR1 on porcine liver sinusoidal endothelial cells (LSEC) is involved in xenogeneic phagocytosis of human platelets in vitro
Effect of alpha-Gal epitopes on the interaction between pig TFPI and human FXa on pig vascular endothelium
Role of the expression of human endothelial protein C receptor and thrombomodulin on GalT-KO PAEC in PC activation
Circulating microparticles plasma levels in primates recipients of hDAF and GalT-KO pig kidney
Absence of thrombotic complication is a major advantage of murine anti CD40 over anti CD154 in heterotopic cardiac xenotransplantation studies
Activated Protein C inhibits platelet activation during xenogeneic GalTKO.hCD39 pig lung perfusion
Soluble TFPI can interfere with xenogenic activation of the human coagulation system and prevents coagulopathy in xenoperfused kidneys
Protective effects of EPCR overexpression in mouse cardiac xenografts and islet isografts
Expression of human thrombomodulin in GTKO/hCD55-hCD59-HTF pigs
Production and characterization of TF knock-down pigs and hTFPI transgenic pigs
Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells
Improved cloning efficiency using hCD55/alpha 1,3-Gal knock-out cell clones selected for high hCD55 expression level
High ubiquitous hCD55 and hCD39 co-expression in live transgenic alpha 1,3-Gal Knock-out piglet
Early graft function of heterotopic cardiac xenografts: lessons learned from a large animal cardiac xenotransplantation program
Combined telemetry and video monitoring offers the most accurate assessment of transplanted xenograft function and recipient baboons health status
Gene targeting and cloning in pigs using fetal liver derived cells
Porcine galactosyl-transferase knock-out transgenic for human CD55, CD59, CD39 kidneys are actually rejected by baboons despite plasma/B cells and complement blockade
Preformed non-Gal antibodies are highly cytotoxic even against Galactosyl-transferase knockout, human CD55, CD59, CD39 transgenic pig organs in a model of kidney transplantation into baboons
Inter-species compatibility: Does human erythrocyte physiology impair the function of porcine hearts?
Prevention of hyper-acute pulmonary xenograft dysfunction using GalT-KO swine in an ex-vivo lung perfusion model
Quality assessment as a predictor for graft function in the pig-to-nonhuman primate islet transplantation model
Manufacturing porcine islets: culture at 22°C has no advantage of culture at 37°C
Comparative analysis of the insulin expression in tilapia pancreatic and extrapancreatic tissues
Development and validation of a novel porcine C-peptide specific ELISA
Real-time assessment of encapsulated neonatal porcine islets prior to clinical xenotransplantation
Novel ex vivo left and right ventricular working heart model for xenotransplantation studies
Cardiopulmonary bypass with reduced priming volume for pig-to-baboon heart transplantation studies
Comparison of hemodynamics in piglets and baboons – implication for a clinical application of cardiac xenotransplantation
Administration of a fluid diet as a means for nutritional supplementation in challenging experimental primate models
Implementation of the three R's Tenet to primate research: application of a new device as a means of long-term enteral administration of drugs or nutritional supplementation
Experience with a training program for cooperative handling in nonhuman primates: reduced stress, improved care, and higher validity of scientific results
Diabetes induction in nonhuman primates using high-dose streptozotocin: evaluation of risk factors and outcomes relevant for cell- and xeno-transplantation
The streptozotocin-induced diabetic nude mouse model: differences between source animals relevant for cell- and xenotransplantation
Bortezomib, a potential elective immunosuppressive drug in xenotransplantation
Post operative management of heterotopic xenograft recipient baboons plays a significant role in survival of both the recipient and the cardiac xenografts
Donor pretreatment with montelukast and atorvastatin improve physiology and histology in xeno mouse lung perfusion
Characterization of human pancreas-derived MSCs and their post-xenotransplantation distribution in mice
Extracorporeal human blood perfusion of CD46 and HLA-E double transgenic pig limbs: a technique for the study of immunologic effects in composite tissue xenografts
Ex vivo xenoperfusion of CD46 and HLA-E double transgenic pig limbs: effect of transgenic expression of human CD46 and role of natural IgM and mannose binding lectin pathway
Human NK cells kill porcine chondrocytes using multiple receptors
MRSA: a problem for xenotransplantation?
Virus safety of xenotransplantation: new methods to screen donor and recipient
Phagocytosis of human platelets involves the CD18 receptor on porcine Kupffer cells
Differences in human and porcine platelet oligosaccharides and differences in human and porcine ASGR1 influence phagocytosis by liver sinusoidal cells in vitro
Pig endothelial cells expressing human thrombomodulin and endothelial protein C receptor and thrombin generation
Circulating microparticles plasma levels in cynomolgus monkeys recipients of porcine neuronal xenograft
Whole blood thromboelastometry profile in renal pig-to-monkey xenotransplantation
Thrombin generation profile in cynomolgus monkey recipients of porcine neuronal xenograft
Large-volume blood transfusion incurs superior hematologic outcome compared to multiple small-volume transfusion in recipients of cardiac xenotransplantation
From organs to cells: a comparative approach to the evolution of regulatory perspectives in xenotransplantation
Establishment of multiple transgenic pig herds for xenotransplantation
AAV2/9-mediated gene transfer of thymosin β4 shows cardioprotective effects in a porcine heterotopic heart transplantation model
The effect of HLA-DR transgenesis on cell-mediated rejection
No tissue discrimination of hDAF/hHO-1 dual transgenes expression in F2 transgenic pigs through dam transmission
CD55 enhances resistance to complement-mediated injury in Gal knockout cardiac xenografts
Intragraft Treg cell-mediated prevention of xeno-islet graft rejection by short term CD40-CD154 blockade treatment
Rapid DC activation and diminished tolerance induction in mice treated with CD47-deficient DST and CD40/CD154 co-stimulatory blockade
Identification of potential GTKO porcine liver xenoantigens recognized by human natural antibodies
Natural ant-Gal and total IgM and IgG levels in GTKO pigs
Alpha-Gal may affect the long term survival via antibody mediated rejection in pig-to-mouse corneal xenotransplantation
In vitro insulin production and in vivo glucose regulation by agarose encapsulated porcine islets are influenced by long-term culture conditions
Prevascularized bio-artificial PLGA device for subcutaneous islet transplantation
Hemoglobin A1C percentage in nonhuman primates: a useful tool to monitor diabetes before and after porcine pancreatic islet xenotransplantation
In comparison with APIs, NICCs are very rich in α2,6Neu5NAc, and reduced Fucose/Core Fucose and high-mannose form, and Lactosamine and Core 1 forms are up-regulated, instead, in 5-day cultures
Comparison of glucose-stimulated insulin secretion between isolated human, nonhuman primate and porcine islets
Synthesis of multilayered alginate microcapsules for release of exendin-4 to treat type 1 diabetes mellitus
Histomorphometric analysis of donor pancreas predicts islet yield and function isolated with adult designated pathogen-free pigs and a GMP-grade enzyme
Absence of LMP-1 expression in lymphocryptovirus-associated PTLD in eight Macaca fascicularis post-neuronal xenotranplantation
Cytological examination of bone marrow fom xenografted cynomolgus monkeys ( Macaca fascicularis )
Quantitative and qualitative evaluation of proteinuria in non-human primate recipients of porcine xenografts
9-day survival and control of thrombocytopenia following liver xenotransplantation in baboons using GalT-KO swine grafts