ABO incompatibility and graft accommodation: potential strategy to prevent acute/chronic antibody mediated rejection
Pancreas transplantation induction with rabbit antithymocyte globulin ± rituximab and early steroid withdrawal: experience with >500 recipients
The assessment of ex-vivo human pancreata using magnetic resonance imaging
Can post-transplant C-peptide be used as an indicator of pancreas graft failure?
Pancreata from pediatric donors restore insulin independence in adult type 1 diabetic recipients
Severe lower limb epidermal nerve fiber loss in diabetic neuropathy is not reversed by long-term normoglycemia following simultaneous pancreas and kidney transplantation
Ocular color doppler ultrasound (OCDUS) assessment of blood flow velocities changes in central retinal artery (CRA) and vein (CRV) after islet transplantation in type 1 diabetic patients: correlation with graft function in a long term study
Successful islet outcomes using Australia wide donors: a national centre experience
Clinical islet allograft transplantation via mini-laparotomy: the benefit of ultrasound guided transversus abdominis plane (TAP)
Cholestatic liver injury after biliary reconstruction impairs transplanted islet viability and function due to oxidative stress
Circulating mirorna 375 levels before islet autotransplantation inversely correlated with post-digestion islet yield
Co-stimulation blockade inducing tolerance to porcine islet xenografts produced Foxp3 + regulatory T cells with high IL-10 production and expressing MHC class II that were capable of dominant tolerance
ABO-tolerance in a murine model of ABO-incompatible heart transplantation (ABOi HTx)
Cryopreserved regulatory T cells (Tregs) isolated from discarded human thymus potently suppress allogeneic and xenogeneic immune responses after expansion
Microbiological screening of wild-type and genetically engineered pigs and transplant recipients in pig to non-human primate xenotransplantation
Non-identical PERV profile observed in cloned pigs
Antibody studies using virus particles displaying xeno-reactive antigens; alpha-Gal, Neu5Gc and SDa-like carbohydrate structures
Impact of PERV infection on the pig transcriptome
Biomarkers of islet graft injury
Progress in kidney xenotransplantation
Twenty years of allogeneic islet transplantation for type 1 diabetes in a single center: trends and progresses
Islet allotransplantation: single centre experience 1989–2015
Five years outcomes from the Australian multicentre trial of islet transplantation
Islet transplantation in the United Kingdom- data from the UK transplant registry
Improvements in multiple cardiovascular biomarkers following islet cell transplantation in patients with type 1 diabetes
Spectral – domain optical coherence tomografy and orbital color-doppler ultrasound in type 1 diabetes after islet transplantation
Effect of GCSF and GLP1 agonist on long-term human islet allograft survival
Impact on access to eventual renal transplantation of allogenic islet transplantation from multiple HLA unmatched donors in non uremic patients
Primary graft function predicts 10 years outcome after islet transplantation
The impact of islet cell transplantation on quality of life in patients with severe hypoglycaemia unawareness
Ten year follow up after islet allotransplantation in patients with brittle type 1 diabetes: the University of Chicago experience
Immunoprotective impact of the kidney in SPK transplants – proceed with live donor kidney or wait for SPK?
Impact of duodenal cuff inflammation on outcome after clinical pancreas transplantation – a survey of a comprehensive follow-up strategy including serial protocol biopsy of the duodenal cuff
Recipient and pancreas graft survival after simultaneous kidney-pancreas transplantation in Australia and New Zealand: a cohort study 1984–2014
Superior pancreatic allograft survival in recipients of simultaneous pancreas and kidney transplants: an updated analysis of the UNOS dataset
Long term outcome of 83 SPLK transplants at a single center
Why are pancreas transplant volumes in the United States declining?
10 Year experience using a steroid free three drug maintenance immunosuppression regimen for pancreas transplant alone: comparison of induction with rabbit antithymocyte globulin ± rituximab
Supra-physiological haemodynamic optimisation improves short-term outcomes following simultaneous pancreas and kidney transplantation: a randomised clinical trial (NCT01619904)
The impact of center volume on outcome of pancreas transplants
Survival benefit of pancreas and/or kidney transplantion for diabetic patients in the United States
Anti-Gal IgM response which is suppressed by anti-CD154, not by anti-CD40, is associated with early graft failure in intraportal porcine islet xenotransplantation
Long-term survival of genetically modified porcine neonatal islet xenografts in baboons
Preclinical studies on porcine islet macroencapsulation in non-human primates
Overexpression of human HO-1 or sTNF-αR-Fc in adult porcine islets using adenoviral transduction or transgenic pigs prolongs islet xenograft survival by suppressing both early apoptosis and inflammation
PERV (porcine endogenous retrovirus) integration and expression in pancreatic islets and other tissues in neonatal and adult pigs
Plasma microRNA-375 – a single test to quantitate injury to porcine islet grafts and to diagnose accelerated porcine islet graft loss in nonhuman primates?
A new bioinformatics analysis reveals intestinal infection as a possible cause of intrahepatic graft rejection in non-human primate porcine islet xenotransplantation
Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a humanized mouse model
Improving porcine islet yield with new recombinant class I (rC1) and class II (rC2) collagenases in combination with BP protease, an animal-free enzyme mixture
Transplantation of alginate-based microencapsulated neonatal porcine islets in diabetes
Bone marrow derived mscs regulates inflammatory microenvironment and ameliorates rats from diabetic nephropathy by inhibiting activation of macrophages
Hematopoietic stem cell mobilization and collection in the rhesus maqaque: the effect of high dose stem cell factor
Imaging of iron nano-particle labelled mesenchymal stem cells in ovine heterotopic kidney transplantation
Gene microarray comparative analysis of interferon-gamma and interleukin-17a preconditioned human mesenchymal stem cells
Comparing with different regimens of Haplo-identical hematopoietic stem cell transplantation in patients with acute myeloid leukemia
MSCs conditioned medium inhibits TNF-α induced human umbilical vein endothelial cells injury
Senescence of cryopreserved umbilical cord mesenchymal stem cells in platelet lysate containing medium
MSCs attenuate high glucose-induced oxidative stress and reduce mitochondrial dysfunction in human umbilical vein endothelial cells
Intravenous injection of human mesenchymal stem cells ameliorated early renal damage in diabetic rhesus monkey model
Peripheral infusion of human umbilical cord MSC rescues monkeys from lethal acute liver failure by inhibiting the activation of circulating monocytes
Treatment with IL-1 receptor antagonist reduces amyloid beta-cell toxicity in human islets: implications in clinical islet transplantation
Preconditioning with diazoxide reduces ischemia-reperfusion injury to rodent and non-human primate pancreata and islets
The presence of diabetes autoantigens in microparticles derived from human islets
Withaferin a prevents islet damage caused by IBMIR: microRNA 375 analysis
Anti-aging glycopeptide protects human islets against tacrolimus-related injury and facilitates engraftment
Identifying mirnas associated with human islet graft rejection in a humanized mouse model
Pancreatic beta-cell expression of IFN-gamma-inducible protein 10 (IP-10/CXCL10) in response to islet cell stress is required for early islet graft loss of function
Co-transplantation with mesenchymal stem cells from chronic pancreatitis patients protects islets from death after transplantation
Peroxisome proliferator-activated receptor-gamma agonist, pioglitazone prevents early graft loss in canine pancreatic islet auto-transplantation
The impact of donor specific antibodies on rejection and graft survival after pancreas transplantation
Conversion from twice daily tacrolimus to once daily modified release tacrolimus in stable pancreas transplant recipients – a safety study
Outcome of pancreas after islet (PAI) transplantation – a report of the international pancreas transplant registry (IPTR)
Incidence, outcomes and predictors of de novo donor specific antibody in pancreas transplantation
Virtual crossmatching for pancreas transplantation is immunologically safe and reduces organ ischaemic time
Virtual HLA crossmatching using single antigen bead luminex assays safely expedites transplantation of imported pancreata
Sirolimus with tacrolimus did not prologed wound healing in pancreas and kidney transplantation – randomized single center study with 5 –year follow-up
Treatment of the high level of donor specific antibodies for successful islet allotransplantation
Sirolimus rescue maintenance therapy for refractory pancreas rejection
Antibody monitoring in pancreas transplantation: subclinical rejection in protocol biopsies in patients with dsa antibodies
Does cardiac risk quantification have a role in assessment for pancreas transplantation?
Targeted genome-wide inactivation of porcine endogenous retrovirus activities (PERVs)
Six-gene multi-transgenic pigs serve as source animals to address innate and chronic rejection, inflammation, and coagulopathy in organ xenografts
The immune profile of donor pigs with ubiquitous expression of LEA29Y
Immune phenotype and IgG characteristics of Neu5Gc and alpha-1-3-gal double knock-out pigs
Targeted transgene insertion in pig cells using a high fidelity CRISPR system
Efficient production of GGTA1−/−/Fah+/− knockout pigs by CRISPR/Cas9 and somatic cell nuclear transfer
A high-throughput method for pig xenoantigen screening based on CRISPR/Cas9 lentiviral libraries
Generation of transgenic pigs expressing a T cell-depleting anti-CD2 monoclonal antibody
Efficient generation of a triple knockout (GGTA1/CMAH/ASGR1) of xenorelevant genes in pig fibroblasts
Targeting tissue factor and GGTA1 expression in pigs for improved xenograft survival
Dose-ranging study of a combination drug with cyclophosphamide(cytoxan) and fludarabine in non-human primates
Analyses of human, monkey, and pig immunologically-related proteins provide insight into xenotransplantation
Effects of interlacing endothelial cells on in-vitro differentiation of induced pluripotent stem cell embryoid bodies into hepatocyte-like cells
Gene therapy for diabetes: reversal of diabetes in the humanised FRG mouse model
Bioengineered insulin-secreting 3D constructs
Developing bone marrow transplant and lentiviral vectors to treat Friedreich ataxia
In situ oxygen biomaterial for extrahepatic islet transplantation
Therapeutic infusion of partially HLA-matched third-party virus-specific T cells (VST) for treatment of refractory viral infection in haematopoietic stem cell transplant (HSCT) and renal transplant patients
Evaluation of phenotype, migration, engraftment and safety of human cord blood derived ex-vivo created di- chimeric cells in NOD SCID mouse model: a preliminary study
Cell therapy using bone marrow derived cell for liver cirrhosis patient
Establishment of feeder free culture of naïve state of porcine iPS cells
GMP isolation and quality assesment on human amnion epithelial cell for clinical therapies
Application of a prominent oxygen-permeable bag for short-time hepatocyte preservation prior to transplantation
Long-term survival of pig-to-primate renal xenotransplant using costimulation-blockade immunosuppression
Prolonged survival of porcine skin on baboons following administration of porcine cells expressing human CD47
Restructuring of a pancreas transplant programme following cusum triggers through implementation of external peer review recommendations: a service review
Schwann cells regulate angiogenesis and blood vessel structure in native and transplanted pancreatic islets
Application of human epineural sheath conduit supported by human mesenchymal stem cells therapy for regeneration of peripheral nerve injuries
Investigation of the mitochondrial transfer from human mesenchymal stem/stromal cells to human primary hepatocytes through tunnelling nanotubes as a potential mechanism for cell survival and function enhancement during hepatocyte transplantation
Newport green for islet-specific viability assay by semi-automated method
Development of a microfluidic-based array for large-scale ordering, high throughput screen and high resolution imaging of islets
Glutamine plays an essential role in the functional and structural integrity of isolated human islets
Examining the role of ferroptosis in islet isolation and transplantation
Pancreas collagen digestion during isolation procedures for islet of langerhans transplantation
Proof of concept for the clinical application of animal component free recombinant collagenase for isolating pancreatic islets
High human islet yield with recombinant class I (rC1) and class II (rC2) collagenases in combination with BP-protease: efficacy of a low dose of an animal-free enzyme mixture on human pancreas digestion
Glial cell-derived neurotrophic factor protects human islets from apoptosis induced by serum starvation and endoplasmic reticulum stress through PI3K/AKT signaling pathway
Mesenchymal stem cells cultured as spheroids (MSC-Sph): a tool for improving pancreatic islet transplantation outcome
How about heparin-pegylated islets in allo-islet transplantation in cynomolgus monkeys
Lack of CD47 on donor hepatocytes induces anti-donor T cell responses: a potential barrier to hepatocyte xenotransplantation
Clinical trial of a cellular porcine corneal matrix in the treatment of corneal ulcer
Effect and safety of anti-CD40 antibody on the survival of corneal xenotransplantation
Experimental study on GTKO/CD46 pig-to-rhesus corneal xenotransplantation
A focus on the role of platelets in liver regeneration: do platelet-liver sinusoidal endothelial cell interactions initiate the regenerative process?
Human rapamycin and IL-10-induced tolerogenic dendritic cells partially inhibit xenogeneic NK and CD8+ T cell responses in vitro
Foxp3+ regulatory T cells are essential for the induction and maintenance of tolerance to neonatal porcine islet cell cluster xenografts induced by co-stimulatory blockade
IL-22-mediated suppression of islet inflammation
3D scaffolds containing living cells
A randomized double-blinded placebo controlled trial of DPP-4 inhibitor therapy after total pancreatectomy with islet autotransplantation
Intraductal delivery of alpha-1-antitrypsin increases the yield of autologous human islets for transplant
Preservation of pancreatic endocrine function after total pancreatectomy and islet autotransplantation. A 6 year follow up
Effects of pylorus preservation procedure on patient outcome in total pancreatectomy with islet autotransplantation
Factors predicting outcomes after a total pancreatectomy and islet autotransplantation: lessons learned from over 500 cases
Efficacy and feasibility of fully automated closed loop insulin pump therapy after islet auto-transplantation
Islet loss and engraftment markers after TPIAT
Endoscopic autologous transplantation of pancreatic islets underneath gastric mucosa – 1-year-follow
Assessement of long-term graft function following total pancreatectomy and autologous islet transplantation
Do surgical complications adversely affect total pancreatectomy with islet autotransplantation outcome?
Maturation of human pluripotent stem cell-derived pancreatic progenitors into monohormonal islet-like cells after transplantation to mice
Protective potential of murine IL-10-induced tolerogenic dendritic cells in rat-to-mouse islets xenotransplantation model
Effective control of early anti-xenogeneic IL-17 response is critical for graft protection in xenogeneic islet cell transplantation
Extrahepatic islet transplantation using bioengineered advanced microfabricated thin-film macroporous microwell scaffolds leads to rapid recovery of normoglycemia in diabetic mice
Bioprinted islet spheroids containing adipose-derived stromal vascular fraction cells using a 3D bioprinting technology improves islet integrity and function
Enhanced effect of shTNFRI and hHO-1 gene expressing hmsc on porcine islet transplantation in humanized mice
INS-eGFP transgenic piglets provide a novel tool for studying maturation and vascularization of neonatal islet cell clusters (NICCs) in vivo
Engineering neoislets from islet-derived mesenchymal stem cells
Using human pancreatic islets as a bioink for 3D bioprinting for bioengineering an artificial pancreas – preliminary report
Direct comparison of adult, juvenile, and neonatal porcine islets in vitro reveals age dependent differences in viability and function
Effect of pig genetic modification on human platelet aggregation in response to pig vascular endothelial cells
Attenuation of high mobility group box 1 (HMGB1)-mediated proinflammatory responses by transgenic expression of human thrombomodulin on pig cells
Effect of C1 esterase inhibitor treatment of wild-type and multi-transgenic (GalTKO/hCD46) porcine aortic endothelial cells in an in vitro pig-to-human transplantation model
In vitro exposure of isolated porcine islets from Neu5Gc-knockout/GT-knockout/hCD46 transgenic donors to human blood/plasma
Unraveling the mechanistic pathways of the instant blood mediated inflammatory reaction
Functional evaluation of immortalized porcine endothelial cells in a whole blood clotting assay
Study of proper expression level of human thrombomodulin in pig endothelial cell with effective anticoagulant activity and no bleeding tendency
Cellular sialylation and activation regulate xenogeneic neutrophil adhesion
Activated protein C modulates the thrombotic phenotype and vascular permeability of GaltKO.hCD46 porcine endothelium expressing human endothelial protein C receptor
Ectopic expression of human CD55 on porcine cells suppresses macrophage-mediated xenogeneic rejection
Human endothelial cell activation through ERK by non-Gal antibody
Endotoxin, protein, and microbiological impurities in alginate hydrogels correlate with immune-mediated destruction after islet transplantation
Alginate composition and temperature influence microcapsule permeability
Key factors influencing alginate microcapsule size, dimensions and long-term stability
Heparinzation of cell surfaces with a heparin-binding peptide-conjugated PEG-lipid for regulation of thromboinflammation in transplantation of human MSC and hepatocyte
Engineering an infectious TREG biomimetic through surface bound TGF-β1 polymers
Microencapsulated non-human primate (NHP) islet allografts and porcine islet xenografts in streptozotocin-diabetic NHPS: islet survival, function, and host responses
Isotropic swelling of alginate microcapsules in aqueous sodium chloride is neutralized at high PH
Biosafe: a novel biomaterial for pancreatic islets encapsulation and type 1 diabetes mellitus therapy
Barium-gelled alginate microcapsules do not exhibit sodium-induced isotropic swelling noted with calcium-gelled microcapsules
Mathematical predictions of oxygen availability in micro- and macro-encapsulated human and porcine pancreatic islets
Engraftment and function of microfluidic PEG-encapsulated islets in a highly vascularized alternative transplant site
Keith reemtsma lecture: xenotransplantation – the past and the future
Mesenchymal stem cells co-transplanted with neonatal porcine islets improve revascularization, more rapid correction of diabetes and long-term graft function in diabetic mice
Living donor islet allografts in haplotype identical macaques: effect of chimerism and anti-donor antibodies on islet allograft survival
Human mesenchymal stromal cells improve survival and function of pancreatic iislets by cell-to-cell contact through N-cadherin
The intra-adrenal islet transplantation model. Convergence of pancreatic islets with endocrine “helper cells”
Genetic polymorphisms in donor tissue determine transplant outcomes
A proteasome inhibitor, bortezomib prevents pancreatic islet graft loss after transplantation
Attenuation of immunosuppression related negative effects on islet grafts by growth hormone releasing hormone (GHRH) agonist
Targeting islet-derived IFN-gamma-inducible protein 10 (IP-10/CXCL10) to prevent early innate immune destruction of islet grafts
Comprehensive gene analysis on ex-vivo mitomycin-C treatment as a potential protocol for inducing unresponsiveness to islet engraftment: harmonized downregulation of multiple chemotaxis factors
Localized release of low-dose dexamethasone from macroporous scaffolds improves islet engraftment in murine model
Pancreatic islet culture induces tolerogenic effects as well as stimulates immune cell trafficking by regulating inflammatory cytokines
Enhanced oxygen supply to islets encapsulated at high density leads to long-term normoglycenia in diabetic rats and facilitates development of smaller devices
Engineering an in vitro platform for characterization of antigen recognition for encapsulated islets
Preclinical validation of the mailpan®, a bioartificial pancreas to treat type 1 diabetes
In vivo and in vitro characterization of 1.5 MM BA2+-alginate macro-encapsulated cynomolgus monkey islets
The development and utility of a prevascularized subcutaneous ‘device-less’ site for beta cell replacement therapy
Effects of activated mesenchymal stromal cells on islet secretory function and cellular overgrowth on microencapsulated islets
Nanobiotechnology to deliver anti-inflammatory agents to islet transplantation sites
Development of novel cell sheet technology; hybrid islet cell sheets laminated with mesenchymal stem cells
Cytokine profiles of juvenile porcine islets during prolonged in vitro culture and after alginate microencapsulation
Automation of microcapsule evaluation and characterization for use in islet transplantation
GGTA1/CMAH/β4GALNT2 knockout porcine cells have reduced human antibody binding and achieved near background thresholds for most transplant patients and remaining antibody binding is partially attributable to swine leukocyte antigen
A new xenoantigen: human natural IGM antibodies bind to non-muscular myosin heavy chain type II on porcine endothelial cells
N-Glycolylneuraminic acid (NEU5GC) knock-out in GALTKO.HCD46 pig lungs improves pulmonary function in a xenogeneic pig-to-human lung perfusion model
Investigation of the potential clinical significance of the expression of NEUGC on pig aortas and corneas
The potential significance of NEUGC in the structural valve deterioration of bioprosthetic heart valves
Increased late graft loss in kidney recipients with serum sickness disease following anti-thymocyte globulin induction: relation with an anti-NEU5GC response
Increased IGM and IGG anti-NEU5GC antibodies in infectious mononucleosis (IMN): link with multiple sclerosis (MS)?
CTLA-4 plays an important role in TREG-mediated suppression of the xenoimmune response
Conjugation of human recombinant CD39 to primary human hepatocytes protects against thromboinflammation
Islet resident macrophages are immunoregulatory and prolong islet transplant survival
Dendritic cell targeted therapy utilising porous silicon nanoparticles
The human monoclonal antibody 3C12C targeting activated dendritic cells is a potential new immunosuppressive agent
Overcoming immune senescence to establish transplantation tolerance
Modification of the “one study” panels for whole blood immunophenotypic monitoring for transplant clinical trials and islet transplant patients at westmead
Safety and efficacy of third-party umbilical cord blood-derived regulatory T cells
Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a humanized mouse model
The distinct apoptotic identity of dendritic cells offers novel targets for immunosupression
The therapeutic potential of human liver-derived stem cells transplantation in a cirrhotic liver rat model
A novel method for murine intrahepatic islet transplantation via cecal vein
Low molecular weight heparin prevents mouse colon cancer liver metastases by inhibiting heparanase and IFNγ inducible chemokines
Bridging therapy of donor-recipient chimeric cell against hematopoietic acute radiation syndrome
Composite membrane protecting implanted islets from allogenic and xenogeneic host immune system
Incubation at physiological temperatures induce irreversible isotropic shrinkage in alginate microcapsules
Evaluation of alginate biocompatibility by analyzing macrophage adhesion during in vitro co-culture
Novel multicompartmental bile acid-based microcapsules for pancreatic β-cell transplantation
Organ-derived micro-scaffolds for the formation of micro-pancreata – further improvements on insulin secretion and stimulation index
Non-invasive assessment of tissue-engineered graft viability with oxygen-17 magnetic resonance spectroscopy
Krüppel-like factor 4 overexpression initiates a mesenchymal-to-epithelial transition and redifferentiation of human pancreatic cells following expansion in long term adherent culture
Overexpression of exogenous PAX4 combined with suppression of endogenous arx enhances beta-cell lineage specification and maturation during the ex vivo transdifferentiation of human exocrine pancreatic tissue
Efficient reprogramming of centenarian's somatic cells, personalized geriatric medicine
3D imaging for islet grafts in the transparent liver by whole-organ clearing method
Development of a reliable real-time assay for evaluating human islet function and viability prior to transplant
A qualitative evaluation of patient experiences following islet transplantation
Successful 12-year outcomes of a national islet transplant program centre
A case report of a type 1 diabetes patient maintaining C-peptide secretion for ten years after islet transplantation using donation after cardiocirculatory death (DCD) donors
Evaluation of pancreatic donors for islet isolation
Islet and pancreas transplantation outcomes in a single transplant centre
Modified islet isolation techniques can isolate high islet yield even from alcoholic pancreatitis pancreases intended for clinical islet auto-transplantion
Pancreatectomy and islet autotransplantation as a final treatment of painful chronic pancreatitis in patients with diabetes
Deficiency of mannose-binding lectin–dependent lectin pathway in the pancreatic islet auto-transplantation
Autologous islet cell transplantation following duodenum sparing total pancreatectomy in situs inversus totalis to treat chronic pancreatitis
Islet autotransplantation after distal pancreatectomy for cystic noeplasms located in the middle part of the pancreas
Total pancreatectomy and islet auto-transplantation for an ampullary carcinoma. A case report
Correlation of the histopathologic staging in chronic pancreatitis with islet isolation and autotransplantation outcome
Successful autologous islet transplantation post-frey's procedure using a side-vented ‘therapeutic infusion needle’ for improved enzyme delivery
Expanding the indications for paediatric and adult autologous islet transplantation
Graft function of “naturally purified” autologous islets isolated from chronic pancreatitis pancreases following total pancreatectomy
Transcriptome analysis of vascular ischemia-reperfusion injury in rhesus monkeys
Pancreas transplantation prevents the progression of morphological, morphometric and ultrastructural changes of testes of alloxan-induced diabetic rats
Drive: diabetes reversing implants with enhanced viability and long-term efficacy
The optimal timing can improve engraftment of pancreatic islets transplanted into the subcutaneous cavity
Bioactive covalent layer-by-layer platforms for cellular encapsulation
Oxygenation of cell encapsulating devices allows for greater survival of cells in vitro
Evaluating various alginate hydrogel compositions and transplant sites for encapsulated islet transplantation
Preparation of immune tolerance site by cyclic peptide for islets transplantation at subcutaneous sites
Engineering an optimal bioartificial pancreas for islet transplantation using oxygen generating scaffold
New strategy of islet viability improvement in bioartificial pancreas using composites islets/MSC-A
Anti-fibrotic effects of rapamycin-containing polyethylene glycol-coated alginate microcapsules in islet xenotransplantation
The effect of DSS-induced colitis on murine intrahepatic islet allograft model
Comparison of islet architecture, beta cell content, and xenoantigenicity
Human islets expressing programmed death ligand 2 regulate immune responses by suppressing T-cells
Co-aggregation of curcumin loaded poly (lactic-co-glycolic acid) microspheres with pancreatic islet cells into heterospheroids; a potential strategy to deliver drugs and biological agents to the islets of langerhans
Development of novel pegylated bilirubin-based nanovesicle (BRNV) for cytoprotection of xenotransplanted pancreatic islets
Decellularized pancreas bioscaffold generation and reconstitution aiming at type 1 diabetes therapeutics
Development of human pancreatic extracellular matrix scaffold and hydrogel platforms for promoting endocrine specification and function from human pluripotent stem cells
Identification of a novel differentially-expressed micro-rna signature profile as a potential biomarker for risk prediction and diagnosis of autoimmune type 1 diabetes
Development of a novel perfusion chamber for studying islet ECM digestion in real-time
Impaired gene expression in pancreatic islets early after isolation can affect the results of gene expression studies
Prolonged in vitro culture at hypoxic conditions does not induce apoptosis in juvenile porcine islets
Donor and isolation-related variables influence young piglet islet isolation outcomes
Comparison of pancreata and islet preparations from a variety of human donors
Improvement of pancreas quality and islet isolation yield by adenosine and oxygen in perfusion solution
Standardized cold shipment of human islets for research
The influence of age on islet size distribution in male and female rats
Profiling of inflammatory reactions caused by intraperitoneal transplantation of alginate-plo-alginate microencapsulated porcine islets in mice
Activation of pancreatic progenitors during isolation of porcine neonatal pancreatic cell clusters
Development of porcine cell lines that lack porcine insulin expression and harbor a human insulin expression vector to be used for xeno-islet cell transplantation
Cost and scalability analysis of porcine islet isolation: comparison of young piglet to adult pigs
Analysis of the cellular composition of juvenile porcine islets during prolonged in vitro culture
Molecular immunology profiles of monkeys xenografted with the islets and hearts of α-1,3-galactosyltransferase knock-out (GALT KO) pigs
High quality porcine islets can be isolated from middle-aged miniature pigs
Regulation of the inflammatory response by human thrombomodulin transgenic pigs in xenotransplantation
Rat-to-Chinese tree shrew heart transplantation: novel small animal model to study non-gal-mediated discordant xenograft humoral rejection
Differences in reactivity of human sera between xenogeneic NEU5GC and α1,3gal antigen
The additional analysis for N-linked sugar of adult pig islets (API) may supplement the previous data
Assessment of perv transmission across an alginate barrier for the encapsulation of porcine islets
Xenoantigen stimulated and expanded baboon regulatory T cells are capable of protecting against porcine islet xenograft rejection in a baboonised mouse model
Hepatic steatosis in immunosuppressed diabetic non-human primate transplanted with pig islets
The consequence of long-term survival of porcine islet graft in immunosuppressed nonhuman primates: giving an opportunity to address three important issues in islet xenotransplantation
Anti-thymocyte globulin (ATG)-induced T-cell depletion in cynomolgus monkey – for the ATG use in non-human primate organ transplant model
Human regulatory macrophages induced in vitro are highly suppressive in xeno-based immune response
Role of natural anti-αGAL antibody repertoire and antibody-mediated damage risk in the clinical use of animal-derived tissues
Quantitative measurement of ICAM-1 expression for developing therapeutic CD40–CD40l blockade
Quantification of cytomegalovirus DNA using a real-time polymerase chain reaction assay in cynomolgus monkey ( Macaca fascicularis )
Comparative study on the methods of determining abo histo-blood group antigens in cynomolgus monkeys ( Macaca fascicularis )
The effect of anti-CD20 antibody treatment in cynomolgus monkeys
Pig pancreas preservation and the influence on islet isolation outcome
The innate immunological response, including the complement system, of pigs against human strongly exist
Pancreas transplantation from living donor: a single center experience of 20 cases
Natural anticoagulant/anti-inflammatory mechanisms
A novel therapy using localized delivery of biopatterned CTLA4/FC fusion proteins to promote islet allograft survival and tolerance
Deciphering the mechanism of action of polyclonal IGM immunotherapy in the prevention of type 1 diabetes onset and progression as well as in the promotion of longitudinal syngeneic and allogeneic islet graft survival following transplantation
Characterisation of the immunomodulatory action of novel anti-CXCR3 monoclonal antibody exploiting a conserved human and murine epitope
Repopulating T cells and alpha1-antitrypsin therapy synergize to remove the immunological barrier to successful islet xenotransplantation
Islet transplantation in the immune privileged eye anterior chamber and immune tolerance induction to treat T1D
Suppression of pancreas autoimmunity using endogenously expanded regulatory T cells
T and B cell signatures associated with survival and rejection of intraportal porcine islet xenografts in immunosuppressed cynomolgus macaques
Circulating CD8+ effector memory T cells – a candidate biomarker for imminent rejection of porcine islet xenografts in nonhuman primates
Pancreas transplantation alone after failure of islet transplantation alone and vice versa: immunization associated risks
Altered intestinal microbial composition as a potential biomarker of dysregulated immunity in type 1 diabetes mellitus
Efficacy of contrast-enhanced ultrasonography for the prediction of the endocrine function of the graft in clinical pancreas transplantation
Higher baseline levels of the bone hormone undercarboxylated osteocalcin independently predict improved islet cell transplantation outcomes
Validation of the beta-2 score: an improved tool to estimate beta-cell function after clinical islet transplantation from a single fasting blood sample
The clinical utility of inflammatory and diabetes markers post simultaneous pancreas and kidney transplantation
Biopsies in pancreas transplantation: the laparoscopic approach
Evaluation of the function of living donor and graft pancreas by using 11C-methionine positron emission tomography for pancreas transplantation
Post-transplantation CA19-9 levels correlate with islet purity and long-term metabolic results after islet transplantation in type 1 diabetes
Contrast enhanced ultrasonography in simultaneous pancreas and kidney transplantation
Continuous oxygen delivery improves oxygenation of tissue-engineered islet grafts in vivo as measured with fluorine-19 magnetic resonance spectroscopy
Vesicular nucleotide transporter (VNUT) protein expressed during the in vitro differentiation of human induced pluripotent stem cells to insulin producing beta cells: a possible marker for beta cell maturation
Genetic modification of islet donor pigs – what is the evidence for improved efficacy?
20 years of experience in isolation and evaluation of human hepatocytes for cell-based therapy
Prolonged survival of hepatocytes transplanted for glycogen storage disease type 1B
Neonatal DCD livers with long warm ischemic times can produce good quality clinical grade hepatocytes
Suppression of the innate immune response using cytoptopic therapeutic agents to prevent early cell loss following hepatocyte transplantation
Hepatocyte transplantation normalizes hypercholesterolemia and aortic accumulation of cholesterol in apolipoprotein E knockout mice
Two cases of hepatocyte transplantation for urea cycle disorders by using hepatocytes isolated from living donor reduced grafts
Therapeutic effects of ectopic liver tissue engineering on lethal acute liver failure in mice
The influence of the synergistic effect of neutral protease derived from clostridium histolyticum and clostripain on the hepatocyte isolation
Improvement of ammonia removal with optimized sized of hepatocyte cluster
Early loss of transplanted islets is prevented by targeting receptor for advanced glycation end products of donor islets in mice
Development of microfluidic devices for islet physiology and transplantation
Glucose dependent insulin secretion rate after standard mixed meal test accurately predicts islet allograft dysfunction in vivo
Protective effect of cyanidin-3-O-glucoside on xenotransplanted neonatal porcine islets through ERK1/2 and PI3K/Akt-induced Nrf2-mediated HO-1 induction
Sphingosine kinase 1 is vital for the function of islets post transplantation
Identifying lncRNAs related to human β-cell function and survival in humanized mouse model
Analysis of gene expression in islet preparations released for transplantation
Humanized mouse model with human islet graft for detecting circulating human β cell-specific biomarkers related to islet graft rejection
Transcriptional and translational regulation of zinc transporter 8 (ZnT8) in human type 1 diabetic (T1D) pancreatic islets
Effect of potential glutathione precursors on human islet survival in hypoxia
Preliminary results of isolated islets after hypothermic machine perfusion of human donor pancreata
Modern era long-term post donation outcomes in 46 live pancreas donors
The survival benefit of donation after cardiac death simultaneous pancreas-kidney transplantation in type 1 diabetics
A systematic review and meta-analysis of donation after cardiac death (DCD) pancreas transplantation and the potential for improving thrombosis rates with ante-mortem interventions
Hypothermic machine perfusion improves the quality of marginal donor pancreata
Machine perfusion of a pancreas prior to islets isolation allows to better islets yield in clinical islets transplantation
Outcome of pancreas transplantation from deceased donors in japan. Japanaese registry data
Donor characteristics of pancreas transplants in Australia and New Zealand: a cohort study 1984–2014
Geographic distance does not preclude successful transplantation across the Australian continent
Good functionality but lower yield after islet isolation from donation after circulatory death pancreata
Factors significantly impacting islet yield from donor pancreata standardized by the north american donor score: a retrospective study from the university of illinois at chicago islet database
Critical need of continuous co-stimulation blockade with anti CD40 antibody (2C10.R4) for long-term maintenance of GTKO.HCD46.hTBM pig cardiac xenograft survival in baboons
Histological evidence of acute rejection after terminating anti CD40 antibody (2C10R4) treatment in GTKO.hCD46.htbm pig to baboon cardiac xenografts surviving for over one year
Cardiac xenotransplantation: Re-emerged b cells after transient depletion by Rituxan treatment maintains their repertoire but have a muted immune response
Enhanced survival of GalT KO/hCD55-hCD59 pig renal xenografts in baboons
Factors contributing to pig kidney graft survival in a baboon for >4 months
CD40mAb costimulation blockade in (life-supporting) heterotopic and orthotopic cardiac xenotransplantation models with GalT-KO/hCD46/hTM transgenic donor pigs into the baboon
Different immunosuppressive regimens in preclinical, discordant xenogeneic, heterotopic thoracic pig-to-baboon heart transplantations
Histological findings in a heterotopic thoracic pig-to-baboon cardiac xenotransplantation model
The three-years experiences of kidney and heart xenotransplantation of pig to non-human primate, which is first trials in Korea
Perioperative management in preclinical pig-to-baboon cardiac xenotransplantation
Complement inhibition by Compstatin CP40 increases cardiac function in a model for preclinical and clinical xenogeneic transplantations
Towards therapeutic application of regulatory T cells: clinical grade isolation, ex vivo expansion and cryopreservation
Effect of phorbol ester in actin remodelling of E cadherin–mediated adhesion of human beta- cells
Acute ischemic exposure leads to functional deficits and a transcriptome enriched in inflammatory and hypoxic pathways in human islets
Amino acid supplementation prevents islet cells death from nutrient deprivation during the peri-transplant period
Embryonic stem cell differentiation into insulin-producing cells (IPCS): functional characterization of the Purkinje cell protein 4 (Pcp4) gene in this process
Development of a new procurement protocol for human pancreas aimed at the generation of decellularized pancreatic scaffolds
Improved survival and better engraftment of human myogenic reserve cells, as compare to human myoblasts, after intramuscular transplantation in immunodeficient mice
Successful human-to-nonhuman primate pancreatic islet intraportal xenotransplantation using a human allo-based immunosuppression regimen
Stimulation of porcine beta-cell proliferation is inhibited with hypoxic culture conditions
Tracking human regulatory T cells (Treg) in a humanized mouse model of porcine islet xenotransplantation
Construction of a cell containing, three-dimensional reconstituted aligned collagen fibril scaffold in a single step
Rapamycin/GABA combination treatment reverses diabetes in nod mice
Role of mesenchymal stromal cells in the prevention of cell death and improvement of metabolism in human primary hepatocytes: focus on micro-rna expression regulation
How to use preservation of rat hepatocytes for cell transplantation?
Bran new cell separation for hepatocyte transplantation using remnant organ with hepatocellular carcinoma after hepatectomy
Amniotic epithelial cells differentiate into hepatic sinusoidal endothelial cells in vivo
The efficacy of spheroidal hepatocyte on hepatocyte transplantation
Characterization and optimization of enzyme components for hepatocyte isolation
Metabonomic analysis of the therapeutic effect of mesenchymal stem cells in a rat model of diabetic nephropathy
Elastin-like extracellular matrix induces erk and akt signal transduction and promotes neuronal progenitor cell survival and proliferation
Effect of melatonin to hormone and ovulation in preovulatory canine
Angiotensin-(1-7) cytoprotective effects on pancreatic islets and its therapeutic potential in diabetes mellitus
A small molecule inhibitor of toll-like receptor-4 (TLR-4) effectively protects islets from IBMIR
Elevated caspase 3 activation levels in the pancreas: a potentially useful predictor of islet isolation outcome
Hypoxic preconditioning protects isolated rat islets from subsequent ischemic injury.
PRL protection of beta-cell general damage restore autophagy markers
PRL-induced cytoprotective and metabolic beneficial effects are mediated by hspb1 on beta-cells
Biologic implant as a repair tool in pancreas transplantation-related necrotic abdominal wall deficiency
Pre-emptive arterial stenting with covered vascular stents to prevent mycotic haemorrhage in infected fields after failed pancreas transplants
Impact of diabetic gastroparesis on outcomes after pancreas transplantation
Pancreas transplantation without revascularization of the splenic artery
A proposal of new marginal donor criteria for pancreas transplantation in japan
Clinical outcome of bk virus associated nephropathy in simultaneous pancreas and kidney transplant recipients
Using the terminal ileum for exocrine drainage in pancreas transplantation – a safe and effective technique
Simultaneous deceased-donor pancreas, living-donor kidney transplantation: single center experience
Excessive weight gain after pancreas transplant: a risk for metabolic syndrome, fatty liver disease and type 2 diabetes
Long term durability of glycemic control after pancreas transplantation
The impact of preoperative cardiovascular interventions on outcome after pancreas transplantation
Arterial stenosis of the pancreatic graft might be associated with acute cellular rejection in pancreas transplantation
Immunologic rejection of a de novo metastatic donor-derived bellini duct carcinoma in a kidney transplant recipient
Abdominal wall reconstruction for large ventral herniae after pancreas transplantation: a single centre experience
Glycosylated hemoglobin A1C as a tool for assessing post-transplant compliance in the evaluation of diabetic patients for transplantation
Pancreas graft from the donor without acceptable liver procurement is probably utilized for transplantation despite the decreased pancreas graft function
Incidence of surgical site infections in pancreas transplant recipients
Advantage of systematic performing both bkv viremia screening and kidney protocol biopsy among SPK tx recipients based on the case of one patient
Endovascular salvage of a pancreas allograft having developed a large AV fistula and aneurysm
Single centre audit of long-term outcomes in patients with type 1 diabetes mellitus receiving simultaneous pancreas and kidney transplantation (SPK) vs. kidney alone – availability of local SPK program potentially influences selection for SPK
Reasons for pancreas non-retrieval: a potentially wasted resource?
Adaptive capacity of human islets to diet induced obesity in vivo: old normal bmi and old obese donor islets retain functional and mass adaptation compared to young donors, but not old superobse (BMI > 40) donor islets
The effect of high glucose on expression of thioredoxin-interacting protein and interluekin-22 on human islets survival and function in vitro and in vivo
Sirt-1 over-expressed transgenic mice using podocin promoter could improve the success rate of pancreatic islet transplantation
Islet heparan sulfate (HS) undergoes oxidant-mediated loss during islet isolation and recovers slowly after islet transplantation
Controlling of co-stimulatory signals using PD-L1 FC fusion protein and anti-CD154 antibody prolongs islet allograft survival synergistically
Survival of subcutaneous islet transplant in hyperoxia
Elastin analogous protein enhances pancreatic islet survival and ameliorates hyperglycemia in streptozotocin-induced diabretic mice by modulating PI3K/Akt/FOXO1 signaling
Intra-omental implantation: a promising novel technique for islets transplantation
Comparison of adult, juvenile and neonatal porcine islets demonstrates age dependent beta-cell fraction, insulin content and insulin secretion
Insulin secretion data analysis of human islet preparations
B10 cells play a role in the immune modulation of pro- and anti-inflammatory immune responses in mouse islet allograft rejection
Enhancement of pre-transplant in-vitro culture of human pancreatic islets by supplementation with human endothelial-derived exosomes
The lipidome of pancreatic islets – biomarker for islet quality and function?
Stimulation of islet revascularization modulating HIF-1α expression using siPHD3
Impact of hyperglycemia on islets revascularization deficiency post intraportale transplantation
Designing a novel artificial transplantation site for human pancreatic islets
In vitro comparison of adult, juvenile, and neonatal porcine islets reveals age dependent resistance to ischemia
Pancreas derived mesenchymal stem cell improve the glucose response of transplanted islets more effectively than adipose tissue derived stem cells
Development of the autologous islet transplantation model with miniature swine
Effect of alpha-cells on rat insulin secretion
Asymmetric distribution of delta and pp cells within human pancreatic islets
L-arginine supplementation improves insulin sensitivity and beta cell function in offsprings of diabetic mothers through Akt and PDX-1 activation
Evaluation of laminin expression and basement membrane integrity in isolated human and juvenile porcine islets
Protection of Necrostatin-1 on prevention the damage of pancreas islet cell induced by TNF-α in vitro
Culturing neonatal islet cell clusters in egm2 medium – a practicable approach to improve islet xenotransplantation outcome
Beta-cell-specific expression of glucagon-like peptide 1 (GLP-1) and activated muscarinic receptor (M3R) improves pig islet secretory function
Revealing a critical cross-talk between beta islet cells and the vasculature in diabetes
Substance P induces angiopoietin 1 gene expression in human islets and promotes their survival in culture
Partial pancreatectomy induces beta cell regeneration in cynomolgus monkey
The influence of previous pregnancy on the functionality of smaller and larger rat islets
Introducing oxygen consumption rate as a quality control tool for research and clinical islet preparations
A surface tension driven pumpless microfluidic device for pancreatic islet research
A study on the toxicity of triptolide on neonatal porcine islet cells in vitro
The insulin receptor antagonist s961 induces minimal proliferation of pancreatic beta cells in non-human primates
Production of knock-in transgenic miniature pigs expressing human CD39 on alpha 1,3-galactosyltransferase (GGTA1) gene locus
Efficient generation of Gal-ko cell lines for scnt by selection with biotin-conjugated IB4-lectin attached to streptavidin-coated magnetic beads
Discovery and implementation of novel pig genotypes using advanced genome technologies with increased survival in primates
Production of talen-mediated gene-modified pigs via somatic cell nuclear transfer
Efficient approach for isolation of α-gal deficient porcine fibroblasts expressing human daf and CD39 using CRISPR/Cas9
Production of alpha 1,3-galactosyltransferase and cytidine monophosphate-n-acetylneuraminic acid hydroxylase gene double-knockout pigs by genome editing and somatic cell cloning
Generation of human CD73 expressing pig under control of porcine Icam-2 promoter
Production of a transgenic hPD-L1 pig for xenotransplantation with the sleeping beauty transposon system
Targeting the PD-1-PD-ligand inhibitory pathway in transgenic pig for xenotransplantation
Modifying pigs to overcome barriers to xenotransplantation
The survival rate of pbmcs from ggta1 knockout pigs generated by talen or crispr/cas9 vector under formosan macaques serum challenges
Generation of knockout pigs using directly pronuclear microinjection with ggta1 talen plasmid dnas
Comparison of directly pronuclear microinjection with 1 site or 4 sites RNA polymerase III promoter-GGTA1 CRISPR/Cas9 plasmid DNAs to generate knockout pigs
Ex-vivo perfusion of alpha-Gal knockout, hCD46/HLA-E double transgenic pig hearts
Effects of a thromboxane synthase inhibitor, 1-BIA, on eicosanoid metabolism in a GalTKO.hCD46 xenogeneic lung perfusion model
A novel, non-viral mRNA delivery system for targeted protein translation in human islets
Using 3-dimensional optical projection tomography to study β-cell mass in diabetes
Islets allotransplantation into gastric submucosa in case of portal hypertension
Elispot assessment of cellular immune alloreactivity in clinical islet transplant recipients
MicroRNA 375 expression in juvenile porcine islets during prolonged in vitro culture
Proinflammatory responses induced by serum deprivation during ex vivo culture after islet isolation: role of il-1 blockade and hiapp
Incidence of de novo hla antibodies following islet transplant alone: impact on outcome and re-transplantation
Effects of etanercept route of administration in clinical allogeneic islet transplantation: an analysis from the collaborative islet transplant registry (CITR)
Human adipose tissue derived stem cells incubated in 1% o2 increase secretion of islet protective factors, improves function and reduces apoptosis in human islet in vitro
Stimulation of human intraislet endothelial cells yields peri-islet capillaries: role of adipose-derived stromal vascular fraction cells and ecgs solution
Adenosine improves human islet survival in a hypoxic environment
Both layers of the human islet double basement membrane are substantially disrupted during islet isolation
North america islet donor score in donor pancreas selection for successful islet isolation for transplantation – a multicenter study
High resolution detection of islet damage by microRNA-375 during and after human isolation procedures
Covalently bound islet survival factors to tissue culture surfaces maintain their biological activity
A successful clinical islet isolation service using normothermic purification: a 5 year overview of 121 isolations utilising pancreata from DBD and DCD donors
Advances in human islet processing towards stable and predictable outcomes
Co-culture with extracellular matrix proteins reduces hypoxia-induced human islet cell death
Pancreas oxygen gas perfusion (persufflation) during preservation improves clinical islet isolation yields and success rates
New multi-transgenic donor pigs and targeted drug treatments extended life-supporting xenogeneic lung function
The effect of human leukocyte antigen-E expression on GalTKO.hCD46 lung xenograft survival and injury in an ex-vivo xenoperfusion model
Effects and mechanisms of carbon monoxide on reducing hyperacute dysfunction and microangiopathy in galt-ko pulmonary xenotransplantation
Regulation of coagulation and fibrinolysis during liver perfusion ex vivo
Development of a novel circuit for physiologic xeno perfusion of porcine livers with fresh whole human blood
IL-8 elaboration may contribute to GalTKO.hCD46 lung xenograft inflammation
Multiplex profiling of plasma proteins after xenogeneic lung exposure
Effect of C5a inhibition on GalTKO.hCD46 pig lung xenograft perfusion
Cardiac xenotransplantation: role of CD4 + CD25hiFoxP3 + T regulatory cells in long-term cardiac xenograft survivors
GalTKO.hCD46+/+. Neu5GC KO porcine livers preserve platelet counts during extra-corporeal perfusion with human blood
Therapeutic regulation of systemic inflammation in xenograft recipients (sixr) in the absence of an adaptive immune response
Hepatocyte transplantation for the assessment of hepatocyte streaming and proliferation
In situ oxygen delivery to islets within an implantable immunoisolating device in vivo enhances viability and function
Controlled reassembly of human donor islet cells into well-defined organoids results in glucose-responsive and functional pseudoislets in vitro, capable of c-peptide production in a mouse kidney capsule transplant model
Intracardially injected neural crest stem cells home to the pancreas and delays disease progression in an animal model for type 1 diabetes
Wnt signaling in pancreatic progenitor and beta cell growth
Development of cell manipulation device using sharp tip electrode applied alternating current electric field for cell transplantation
Increasing islet density within an immunoisolation device has a detrimental impact on viability in vivo
Preconditioned hmscs and huvecs boost revasularisation of human islets in a subcutaneous transplantation site
Co-culture with primary liver cells improves maturation and differentiation of human induced pluripotent stem cells-derived hepatocyte-like cells
Hepatocyte, a cell source for liver regeneration and organogenesis